Eventos adversos com medicação em Serviços de Emergência: condutas profissionais e sentimentos vivenciados por enfermeiros Eventos adversos con medicaciones en Servicios de Urgencia: conductas profesionales y sentimientos vividos por los enfermeros Medication adverse events in Emergency Department: nurse's professional conduct and personal feelings

O estudo teve por objetivos verificar as condutas profissionais e os sentimentos dos enfermeiros de serviços de Emergência frente a um evento adverso com medicação e suas associações com a idade, tempo de formado, tempo de experiência na área e vivência anterior com esse tipo de evento. A amostra foi constituída por 116 enfermeiros atuantes em 15 hospitais gerais do município de São Paulo que responderam a um questionário sobre uma situação fictícia com erro de medicação. Os resultados revelaram as seguintes condutas em ordem de prioridade: comunicar ao médico (69,8%), intensificar os cuidados ao paciente (55,1%) e anotar no prontuário (28,0%). A preocupação (79,3%) foi a manifestação afetiva predominante (79,3%), seguida pela impotência e raiva (22,4%, cada um) e insegurança (24,4%). A análise das variáveis mostrou relação entre as condutas profissionais e tempo de formado, enquanto que os sentimentos relacionaram-se com a idade e vivência anterior com esse tipo de evento.<br>El estudio tuvo como objectivo verificar las conductas profesionales y los sentimientos de los enfermeros del servicio de emergencia que se encuentra adelante de un evento adverso com medicación y sus asociaciones com la idad, tiempo del graduado, tiempo de experiencia en la area y vivencia anterior com neste tipo del evento. La muestra fue constituida por 116) enfermeros actuantes em 15 hospitales generales del municipio de São Paulo que respondieram a un cuestionario sobre una situación ficticia com error de medicaciones. Los resultados demonstraron las siguientes conductas en orden de prioridades: comunicar al médico (69,8%), intensificar los cuidados al paciente (55,1%) y anotar en el prontuario (28,0%). La preocupacion (79,3%) fue la manifestacion afectiva predominante (79,3%), seguida por la impotencia y rabia (22,4% cada una) y inseguridad (24,4%). La analise de las variables demonstró relaciones entre las conductas profesionales y tiempo de graduado, mientras que los sentimientos se relacionaran com la idad y vivencia anterior com este tipo de evento.<br>The study had as objectives to verify the professional conduct and feelings of nurses from Emergency Department when they are faced with an adverse event related to medication therapy and to verify its associations with such factors as age, time of completion of college degree, time of experience in the field and previous history with this type of event. The sample was composed of 116 nurses working in various general hospitals in the municipality of Sao Paulo who answered a questionnaire about a fictitious situation related with a medication error. The results revealed the following conducts in order of priority: communicate the physician (69,8%), intensify patient care (55,1%) and make proper annotations in the patient's chart. The most prevailing affective manifestation was to worry (79,3%), followed by impotence and rage (22,4% each) and insecurity (22,4%). The variable analysis showed a relationship between the professional conduct and the time of completion of college degree, while the feelings were related to age and previous experience with this type of event

Revealing the biotechnological potential of Delftia sp. JD2 by a genomic approach

Delftia sp. JD2 is a chromium-resistant bacterium that reduces Cr(VI) to Cr(III), accumulates Pb(II), produces the phytohormone indole-3-acetic acid and siderophores, and increases the plant growth performance of rhizobia in co-inoculation experiments. We aimed to analyze the biotechnological potential of JD2 using a genomic approach. JD2 has a genome of 6.76Mb, with 6,051 predicted protein coding sequences and 93 RNA genes (tRNA and rRNA). The indole-acetamide pathway was identified as responsible for the synthesis of indole-3-acetic acid. The genetic information involved in chromium resistance (the gene cluster, chrBACF,) was found. At least 40 putative genes encoding for TonB-dependent receptors, probably involved in the utilization of siderophores and biopolymers, and genes for the synthesis, maturation, exportation and uptake of pyoverdine, and acquisition of Fe-pyochelin and Fe-enterobactin were also identified. The information also suggests that JD2 produce polyhydroxybutyrate, a carbon reserve polymer commonly used for manufacturing petrochemical free bioplastics. In addition, JD2 may degrade lignin-derived aromatic compounds to 2-pyrone-4,6-dicarboxylate, a molecule used in the bio-based polymer industry. Finally, a comparative genomic analysis of JD2, Delftia sp. Cs1-4 and Delftia acidovorans SPH-1 is also discussed. The present work provides insights into the physiology and genetics of a microorganism with many potential uses in biotechnology