The Peculiar Balmer Line Profiles of OQ 208

We present spectrophotometric observations of the Broad Line Radio Galaxy OQ 208 (Mrk 668, 1404+286) obtained between 1985 and 1991. We show that the Balmer line fluxes and profile shapes undergo remarkable changes. The ratio of intensities between the broad and narrow components of Hbeta increased monotonically from 15 in 1985 to 40 in 1991. The peak of the broad components of Hbeta and Halpha were known to be strongly displaced to the red. We have discovered a correlation between the amplitude of the broad peak displacement and the luminosity of Hbeta, in the sense that the displacement is larger when the line luminosity is higher. We suggest that the observations are not compatible with either a binary Broad Line Region model or one involving ballistic acceleration of the line emitting gas. Radiative acceleration of a system of outflowing clouds readily explains the correlation between line shift and luminosity as well as the peculiar line profiles. Furthermore, it seems that most or all of the Balmer emission originates from the inward face of the clouds. Theoretical line profiles suggest that the observed Hbeta profile is best fit assuming the contribution of an ensemble which might be spherical or confined in a thick disk in addition to a component emitted in a thin shell contained in a cone of half opening angle 12 degrees seen along its axis.Comment: 28 pages + tables and figures available upon request, Latex, No preprint numbe

Fever episodes in early life and the development of atopy in children with asthma

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Optical study of the vibrational and dielectric properties of BiMnO3

BiMnO3 (BMO), ferromagnetic (FM) below Tc = 100 K, was believed to be also ferroelectric (FE) due to a non-centro-symmetric C2 structure, until diffraction data indicated that its space group is the centro-symmetric C2/c. Here we present infrared phonon spectra of BMO, taken on a mosaic of single crystals, which are consistent with C2/c at any T > 10 K, as well as room-temperature Raman data which strongly support this conclusion. We also find that the infrared intensity of several phonons increases steadily for decreasing T, causing the relative permittivity of BMO to vary from 18.5 at 300 K to 45 at 10 K. At variance with FE materials of displacive type, no appreciable softening has been found in the infrared phonons. Both their frequencies and intensities, moreover, appear insensitive to the FM transition at Tc

Optical phase coherent timing of the Crab nebula pulsar with Iqueye at the ESO New Technology Telescope

The Crab nebula pulsar was observed in 2009 January and December with a novel very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we computed accurate phase coherent timing solutions for the two observing runs and over the entire year 2009. Our statistical uncertainty on the determination of the phase of the main pulse and the rotational period of the pulsar for short (a few days) time intervals are $\approx 1 \, \mu$s and ~0.5 ps, respectively. Comparison with the Jodrell Bank radio ephemerides shows that the optical pulse leads the radio one by ~240 $\mu$s in January and ~160 $\mu$s in December, in agreement with a number of other measurements performed after 1996. A third-order polynomial fit adequately describes the spin-down for the 2009 January plus December optical observations. The phase noise is consistent with being Gaussian distributed with a dispersion $\sigma$ of $\approx 15 \, \mu$s in most observations, in agreement with theoretical expectations for photon noise-induced phase variability.Comment: 10 pages, 5 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Small and large polarons in nickelates, manganites, and cuprates

By comparing the optical conductivities of La_{1.67}Sr_{0.33}NiO_{4} (LSNO), Sr_{1.5}La_{0.5}MnO_4 (SLMO), Nd_2CuO_{4-y} (NCO), and Nd_{1.96}Ce_{0.04}CuO_{4} (NCCO), we have identified a peculiar behavior of polarons in this cuprate family. While in LSNO and SLMO small polarons localize into ordered structures below a transition temperature, in those cuprates the polarons appear to be large, and at low T their binding energy decreases. This reflects into an increase of the polaron radius, which may trigger coherent transport.Comment: File latex, 15 p. incl. 4 Figs. epsf, to appear on the Journal of Superconductivity - Proc. "Stripes 1996" - Roma Dec 199

Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?

Carnitine palmitoyl transferase I (CPT1) catalyzes the transport of long-chain fatty acids into mitochondria for beta-oxidation. A link between CPT1 and apoptosis has been suggested on the basis of several experimental data. Nevertheless, results are contradictory about the effective role of CPT1 in cell survival control and cancer development. Conversely, Fatty acid synthase (FAS) enzyme, required for the synthesis of fatty acids, is found over-expressed in tumors and inhibition of FAS triggers apoptosis in human cancer cells. We have studied the tumor-specific modulation of CPT1 and FAS in human colorectal cancer (n = 11) and breast carcinomas (n = 24). CPT1 was significantly decreased in the cytoplasm of tumoral samples (p < or = 0.04), whereas FAS was increased (p < or = 0.04). A striking CPT1 nuclear localization was evident in the tumors (p < or = 0.04). In the nuclear environment the protein would modulate the levels of acetyl/acyl-CoA implicated in the regulation of gene transcription. At this purpose, we performed in vitro experiments using epithelial neoplastic (MCF-7, Caco-2, HepG2 cells) and non neoplastic cell lines (MCF-12F) confirming a nuclear localization of CPT1 protein exclusively in neoplastic cells. Moreover histone deacetylase (HDAC) activity showed significantly higher levels in nuclear extracts from neoplastic than from control cells. HDAC1 and CPT1 proteins coimmunoprecipitated in nuclear extracts from MCF-7 cells. The treatment with HDAC inhibitors such as trichostatin A and butyrate significantly decreased nuclear expression of CPT1 and its bond to HDAC1. We also identified the existence of CPT1A mRNA transcript variant 2 in MCF-7, beside to the classic isoform 1. The peculiar localization of CPT1 in the nuclei of human carcinomas and the disclosed functional link between nuclear CPT1 and HDAC1 propose a new role of CPT1 in the histonic acetylation level of tumors

Aqueye optical observations of the Crab Nebula pulsar

We observed the Crab pulsar in October 2008 at the Copernico Telescope in Asiago - Cima Ekar with the optical photon counter Aqueye (the Asiago Quantum Eye) which has the best temporal resolution and accuracy ever achieved in the optical domain (hundreds of picoseconds). Our goal was to perform a detailed analysis of the optical period and phase drift of the main peak of the Crab pulsar and compare it with the Jodrell Bank ephemerides. We determined the position of the main peak using the steepest zero of the cross-correlation function between the pulsar signal and an accurate optical template. The pulsar rotational period and period derivative have been measured with great accuracy using observations covering only a 2 day time interval. The error on the period is 1.7 ps, limited only by the statistical uncertainty. Both the rotational frequency and its first derivative are in agreement with those from the Jodrell Bank radio ephemerides archive. We also found evidence of the optical peak leading the radio one by ~230 microseconds. The distribution of phase-residuals of the whole dataset is slightly wider than that of a synthetic signal generated as a sequence of pulses distributed in time with the probability proportional to the pulse shape, such as the average count rate and background level are those of the Crab pulsar observed with Aqueye. The counting statistics and quality of the data allowed us to determine the pulsar period and period derivative with great accuracy in 2 days only. The time of arrival of the optical peak of the Crab pulsar leads the radio one in agreement with what recently reported in the literature. The distribution of the phase residuals can be approximated with a Gaussian and is consistent with being completely caused by photon noise (for the best data sets).Comment: 7 pages, 7 figures. Accepted for publication in Astronomy and Astrophysic

Physical Functional Assessment in Older Adults

The evaluation of the physical domain represents a critical part of the assessment of the older person, both in the clinical as well as the research setting. To measure physical function, clinicians and researchers have traditionally relied on instruments focusing on the capacity of the individual to accomplish specific functional tasks (e.g., the Activities of Daily Living [ADL] or the Instrumental ADL scales). However, a growing number of physical performance and muscle strength tests has been developed in parallel over the past three decades. These measures are specifically designed to: 1) provide objective results (not surprisingly, they are frequently timed tests) taken in standardized conditions, whereas the traditional physical function scales are generally self- or proxy-reported measures; 2) be more sensitive to changes; 3) capture the real biology of the function through the assessment of standardized tasks mirroring specific functional subdomains; and 4) mirror the quality of specific mechanisms underlying more complex and multidomain functions. Among the most commonly used instruments, the usual gait speed test, the Short Physical Performance Battery, the handgrip strength, the Timed Up-and-Go test, the 6-minute walk test, and the 400-meter walk test are widely adopted by clinicians and researchers. The clinical and research importance of all these instruments has been demonstrated by their predictive capacity for negative health-related outcomes (i.e., hospitalization, falls, institutionalization, disability, mortality). Moreover, they have shown to be associated with subclinical and clinical conditions that are also not directly related to the physical domain (e.g., inflammation, oxidative stress, overall mortality). For this reason, they have been repeatedly indicated as markers of wellbeing linked to the burden of multiple chronic conditions rather than mere parameters of mobility or strength. In this work protocols of the main tests for the objective assessment of physical function in older adults are presented

Sarcopenia and SARC-F: “Perfect is the Enemy of Good”

In this issue of The Journal of the American Medical Directors Association (JAMDA), Voelker and colleagues present the results of a systematic review and meta-analysis measuring the reliability and concurrent validity of the SARC-F.1 The study reports data gathered from 29 articles and more than 20,000 participants. Overall, the SARC-F shows relatively good inter-rater and test-retest reliability. However, the authors conclude that despite its high specificity, the low to moderate sensitivity of the SARC-F makes it nonoptimal for the screening of sarcopenia. Moreover, Voelker and colleagues tend to discourage the use of the SARC-F, suggesting the direct application of the diagnostic criteria for sarcopenia without prior screening