Valoración de bajo peso, sobrepeso y obesidad de los niños/as de la Escuela Agustín Cuesta Vintimilla del cantón Cuenca 2010

Es un estudio de corte transversal que permitió determinar la prevalencia de la mal nutrición en los niños/as de la escuela fiscal mixta Agustín Cuesta Vintimilla .- Para alzar la información se construyó los siguientes instrumentos: formulario de encuesta sobre la condición socioeconómica que se aplicó a los padres de familia de los niños sujetos de la investigación, formulario para el registro de la antropometría de los niños, se utilizó además las tablas de Índice de Masa Corporal (IMC) y las curvas de crecimiento de la NCHS.- Resultados: de la investigación se desprende que los niños/as tienen un peso normal con 80,03%, porcentajes menores se encuentra con bajo peso el 12,12%, y sobrepeso el 7,58%. Esto es debido a que la situación económica de las familias está entre regular y buena.- Conclusión: se concluye que en la escuela Agustín Cuesta Vintimilla, los niños/as no presentan mayor problema de malnutrición ya que su alimentación se basa en productos propios de su zona. auLicenciado en EnfermeríaCuenc

Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Agencia Española del Medicamento; Consejería de Salud de Andalucía.Background & Aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into the Spanish DILI Registry over a 20-year time period. Methods: Cases were identified, diagnosed and followed prospectively. Clinical features, drug information and outcome data were collected. Results: A total of 843 patients, with a mean age of 54 years (48% females), were enrolled up to 2018. Hepatocellular injury was associated with younger age (adjusted odds ratio [aOR] per year 0.983; 95% CI 0.974-0.991) and lower platelet count (aOR per unit 0.996; 95% CI 0.994-0.998). Anti-infectives were the most common causative drug class (40%). Liver-related mortality was more frequent in patients with hepatocellular damage aged ≥65 years (p = 0.0083) and in patients with underlying liver disease (p = 0.0221). Independent predictors of liver-related death/transplantation included nR-based hepatocellular injury, female sex, higher onset aspartate aminotransferase (AST) and bilirubin values. nR-based hepatocellular injury was not associated with 6-month overall mortality, for which comorbidity burden played a more important role. The prognostic capacity of Hy's law varied between causative agents. Empirical therapy (corticosteroids, ursodeoxycholic acid and MARS) was prescribed to 20% of patients. Drug-induced autoimmune hepatitis patients (26 cases) were mainly females (62%) with hepatocellular damage (92%), who more frequently received immunosuppressive therapy (58%). Conclusions: AST elevation at onset is a strong predictor of poor outcome and should be routinely assessed in DILI evaluation. Mortality is higher in older patients with hepatocellular damage and patients with underlying hepatic conditions. The Spanish DILI Registry is a valuable tool in the identification of causative drugs, clinical signatures and prognostic risk factors in DILI and can aid physicians in DILI characterisation and management. Lay summary: Clinical information on drug-induced liver injury (DILI) collected from enrolled patients in the Spanish DILI Registry can guide physicians in the decision-making process. We have found that older patients with hepatocellular type liver injury and patients with additional liver conditions are at a higher risk of mortality. The type of liver injury, patient sex and analytical values of aspartate aminotransferase and total bilirubin can also help predict clinical outcomes