Computer program FPIP-REV calculates fission product inventory for U-235 fission

Computer program calculates fission product inventories and source strengths associated with the operation of U-235 fueled nuclear power reactor. It utilizes a fission-product nuclide library of 254 nuclides, and calculates the time dependent behavior of the fission product nuclides formed by fissioning of U-235

Function generator eliminates necessity of series summation

Diode generator using four building-block circuits produces complex waveforms without the necessity of series summation. This highly specialized method of producing complex waveforms requires less power than present methods and uses simpler circuitry

The West: slowing, but still strong

Federal Reserve District, 12th

Tower Foundations Bearing Above Weak Soils

A 13-level reinforced concrete structure was constructed on Marco Island in southwest Florida. The tower is located 200 feet from the Gulf of Mexico and has plan area dimensions of 115 by 170 feet. The field testing revealed the site was mantled with a 17-foot thick layer of firm sand. The sand stratum was underlain by a compressible 9-foot thick layer of silty sand which had an average SPT N-value of less than 2. Various methods of engineering analyses estimated total tower settlements to range from 1 to 8 inches. Actual measured settlement following the application of dead load was about 1 3/4 inches. An engineering inspection following construction revealed diagonal shear wall cracks

Seeing Is Believing: The CSI Effect Among Jurors in Malicious Wounding Cases

With the popularization of television crime shows that focus heavily on forensic science, such as CSI and its spin-offs, concerns about a new threat to jury trials have emerged in recent years. Dubbed the “CSI effect,” this phenomenon has reportedly come to influence the way jurors perceive forensic evidence at trials based on the way forensic evidence is presented on television. While the CSI effect has been the topic of much discussion throughout the popular press, the CSI effect has seldom been empirically tested. In this study, we present a selection of media accounts as well as criminological and legal literature that provides a review of the current state of the CSI effect. Additionally, we present the findings of a survey of 60 jurors from five malicious wounding cases on the influence of viewing CSI on jury decision-making. Using a logistic regression model, we found that belief in the accuracy of the scientific methods used on CSI was significantly related to juror verdicts

Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations) and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies) types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival.</p> <p>Methods</p> <p>This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at <it>P </it>< 0.05 used to identify independent factors.</p> <p>Results</p> <p>Inflections in gender ratios by age at diagnosis in years delineated two distinct groups: above and below age 35 at diagnosis. Closer analysis confirmed the above 35 age group as previously reported for adult-type GIST, typified by mixed primary tumor sites and gender, KIT or PDGFRα mutations, and shorter survival times. The pediatric group (< age 18 at diagnosis) was also as previously reported with predominantly stomach tumors, females, wild-type GIST or SDH mutations, and extended survival. "Young adults" however formed a third group aged 18-35 at diagnosis, and were a clear mix of these two previously reported distinct sub-types.</p> <p>Conclusions</p> <p>Pediatric- and adult-type GIST have been previously characterized in clinical settings and these observations confirm significant prognostic factors for each from a diverse real-world cohort. Additionally, these findings suggest that extra diligence be taken with "young adults" (aged 18-35 at diagnosis) as pediatric-type GIST may present well beyond adolescence, particularly as these distinct sub-types have different causes, and consequently respond differently to treatments.</p

Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices

UNLABELLED: Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with limited fluid volumes. We demonstrate that branching, laser-cut grooves can provide a 59.23-73.98% improvement in flow rate over a single cut, and a 435% increase over paper alone. These design considerations can be applied to more complex microfluidic devices with the aim of increasing the flow rate, and could be used in stand-alone channels for self-pumping. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10404-023-02679-8