Evaluation of Sidewalk Autonomous Delivery Robot Interactions with Pedestrians and Bicyclists [Research Brief]

69A3551747109Information and communication technology advancements and an increased demand for contactless deliveries following the Covid-19 pandemic outbreak resulted in the growing adoption of automated delivery services. In this research project, we examine the impacts that sidewalk autonomous delivery robots (SADRs) have on the objective safety and perceived comfort of pedestrians and bicyclists who share pathways with this last-mile food delivery service that has been deployed on college campuses

Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib

Background: Vismodegib, a first-in-class Hedgehog pathway inhibitor, was US Food and Drug Administration (FDA) approved for advanced basal cell carcinomas (BCCs) based on a single, nonrandomized, phase-II trial. Consequently, additional clinical data are critical to confirm the efficacy and safety of vismodegib

Evaluation of Sidewalk Autonomous Delivery Robot Interactions with Pedestrians and Bicyclists

69A3551747109Information and communication technology advancements and an increased demand for contactless deliveries after the Covid-19 pandemic outbreak have resulted in the growing adoption of automated delivery services. Across university campuses, the deployment of sidewalk autonomous delivery robots (SADRs) has provided students, staff, and faculty a convenient last-mile delivery option. However, SADRs traverse campuses on paths designed for pedestrians and bicyclists, which could potentially result in conflicts among different pathway users and unsafe travel conditions. This report\u2014comprising two studies\u2014offers evidence on the objective safety and perceived comfort experienced by pedestrians and bicyclists interacting with SADRs on multi-use paths. In the first study, SADR interactions with human pathway users observed via field-recorded video collected at Northern Arizona University (NAU) campus were examined by employing the surrogate safety measure of post-encroachment time. The second study analyzed the reported comfort of SADR-involved interactions filmed from pedestrian and bicyclist perspectives and collected via the administration of a survey instrument to an NAU population with experience in the adoption of automated food delivery services and SADR-involved interactions. This report\u2019s findings are intended to help inform new facility management strategies that support the safe introduction of SADRs on shared-use facilities in current and future settings

Environmental and Molecular Mutagenesis Meeting Report Assessing Human Germ-Cell Mutagenesis in the Post-Genome Era: A Celebration of the Legacy of William Lawson (Bill) Russell

ABSTRACT Although numerous germ-cell mutagens have been identified in animal model systems, to date, no human germ-cell mutagens have been confirmed. Because the genomic integrity of our germ cells is essential for the continuation of the human species, a resolution of this enduring conundrum is needed. To facilitate such a resolution, we organized a workshop at The Jackson Laboratory in Bar Harbor, Maine on September [28][29][30] 2004. This interactive workshop brought together scientists from a wide range of disciplines to assess the applicability of emerging molecular methods for genomic analysis to the field of human germ-cell mutagenesis. Participants recommended that focused, coordinated human germ-cell mutation studies be conducted in relation to important societal exposures. Because cancer survivors represent a unique cohort with well-defined exposures, there was a consensus that studies should be designed to assess the mutational impact on children born to parents who had received certain types of mutagenic cancer chemotherapy prior to conceiving their children. Within this high-risk cohort, parents and children could be evaluated for inherited changes in (a) gene sequences and chromosomal structure, (b) repeat sequences and minisatellite regions, and (c) global gene expression and chromatin. Participants also recommended studies to examine trans-generational effects in humans involving mechanisms such as changes in imprinting and methylation patterns, expansion of nucleotide repeats, or induction of mitochondrial DNA mutations. Workshop participants advocated establishment of a bio-bank of human tissue samples that could be used to conduct a multiple-endpoint, comprehensive, and collaborative effort to detect exposure-induced heritable alterations in the human genome. Appropriate animal models of human germ-cell mutagenesis should be used in parallel with human studies to provide insights into the mechanisms of mammalian germ-cell mutagenesis. Finally, participants recommended that 4 scientific specialty groups be convened to address specific questions regarding the potential germ-cell mutagenicity of environmental, occupational, and lifestyle exposures. Strong support from relevant funding agencies and engagement of scientists outside the fields of genomics and germ-cell mutagenesis will be required to launch a full-scale assault on some of the most pressing and enduring questions in environmental mutagenesis: Do human germ-cell mutagens exist, what risk do they pose to future generations, and are some parents at higher risk than others for acquiring and transmitting germ-cell mutations?

Review of school vision screening guidelines

Abstract: Background: Vision screenings are important in identifying visual anomalies likely to disrupt the physical, intellectual, social and emotional development of children. School health services globally include vision screenings, complementing a variety of associated screening services. Aim: This review article provides evidence for content, provision and efficacy of the vision screening services for children of school-going age and reports on the current practice of children’s vision screenings worldwide including in South Africa. Methods: Studies were identified from PubMed, Ebscohost and Science Direct with the search terms utilised during the selection of electronic articles and journals for the review. The target population includes children of school-going age from 6 to 19 years without previously known conditions associated with visual anomalies and learning-related problems. The quality of vision screening programmes and policies for the school-going age children in different countries were evaluated using Wilson and Jungner criteria.1 Results: Vision screening programmes worldwide appear to support comprehensive vision screening methods among pre-schoolers (from birth to ≤ 6 years vs. children of school-going age). The development of vision screening procedures in some countries in the United States of America (USA) was found to be grounded on epidemiologic findings and principles. These may have contributed towards the formulation of national vision screening guidelines for preschoolers that supported the detection of amblyopia and its associated conditions such as strabismus, anisometropia and myopia. School-going children’s vision screenings are not supported worldwide as research has shown that there is lack of benefits for detecting other visual anomalies such as vergence and accommodative dysfunctions. This is despite evidence provided by the literature reviewed that an association exists between prevalent accommodation and vergence dysfunctions including poor ocular motilities and poor near-vision, among children of school-going age with poor academic performance. Conclusion: The guidelines worldwide support school vision screenings, especially for the pre-schoolers by the school health nurses, with other programs having considered the teachers, optometrists or orthoptists as the appropriate personnel to conduct the school vision screenings. There is still a need for the effectiveness of the school vision-screening programmes to be investigated related to the importance of detecting convergence and accommodative dysfunctions for the school going age children

The Native American voice in United States water rights

The definitive peer-reviewed and edited version of this article is published in Journal of Water Sanitation and Hygiene for Development 5(2), pp.173-182, 2015 http://dx.doi.org/10.2166/washdev.2015.089 and is available at www.iwapublishing.comThere is a sacred relationship between Native Americans and the environment. The importance of those sacred beliefs in water rights in the United States (US) is examined through a series of case studies. A thorough review of available literature displays a trend toward less dependence on the US for representation and a greater recognition of Native American traditions. The increased role of Native Americans in water rights quantification and resource development provides greater appreciation and understanding of their traditions and beliefs

Research Program at Maxey Flats and Consideration of Other Shallow Land Burial Sites

The Maxey Flats research program is a multidisciplinary, multilaboratory program with the objectives to define the radiochemical and chemical composition of leachates in the burial trenches, define the areal distribution of radionuclides on the site and the factors responsible for this distribution, define the concentrations of radionuclides in vegetation both on and offsite and the uptake of radionuclides by representative agricultural crops, define the atmospheric pathways for radionuclide transport and the mechanisms involved, determine the subsurface migration rates of radionuclides and the chemical, physical, biological, and hydrogeological factors which affect this migration. and evaluate the engineering practices which influence the seepage of surface waters into the burial trenches. The program was initiated in 1979 and a research meeting was held at the Nuclear Regulatory Commission Headquarters on July 16, 1980, to report the research findings of each of the participating laboratories and universities. Important observations from the research are included in the Summary and the results reported for each of the research efforts are summarized in the individual reports that are combined to form this document