Definition of environmental indicators for a fast estimation of landslide risk at national scale

The purpose of this paper is to propose a new set of environmental indicators for the fast estimation of landslide risk over very wide areas. Using Italy (301,340 km2) as a test case, landslide susceptibility maps and soil sealing/land consumption maps were combined to derive a spatially distributed indicator (LRI—landslide risk index), then an aggregation was performed using Italian municipalities as basic spatial units. Two indicators were defined, namely ALR (averaged landslide risk) and TLR (total landslide risk). All data were processed using GIS programs. Conceptually, landslide susceptibility maps account for landslide hazard while soil sealing maps account for the spatial distribution of anthropic elements exposed to risk (including buildings, infrastructure, and services). The indexes quantify how much the two issues overlap, producing a relevant risk and can be used to evaluate how each municipality has been prudent in planning sustainable urban growth to cope with landslide risk. The proposed indexes are indicators that are simple to understand, can be adapted to various contexts and at various scales, and could be periodically updated, with very low effort, making use of the products of ongoing governmental monitoring programs of Italian environment. Of course, the indicators represent an oversimplification of the complexity of landslide risk, but this is the first time that a landslide risk indicator has been defined in Italy at the national scale, starting from landslide susceptibility maps (although Italy is one of the European countries most affected by hydro-geological hazards) and, more in general, the first time that land consumption maps are integrated into a landslide risk assessment

Contenimento naturale di Bactrocera oleae (Rossi): clima o parassitoidi? Confronto tra Western Cape (Sud Africa) e Sicilia

Bactrocera oleae (Rossi), mosca delle olive, e\u300 presente anche in Sud Africa, ma finora non si sono avute notizie di infestazioni economicamente rilevanti negli oliveti. L\u2019accertata presenza di un maggior numero di braconidi parassitoidi della mosca delle olive rispetto alle aree mediterranee e\u300 stata ed e\u300 considerata da molti autori la principale causa di queste minori infestazioni, senza che pero\u300 siano stati eseguiti in Sud Africa adeguati studi sulle infestazioni da B. oleae e sui fattori cli- matici delle aree interessate. Analizzando recenti dati sui livelli d\u2019infestazione di B. oleae registrati su olivo coltivato e selvatico nel Western Cape e in Sicilia, appaiono simili in una normale annata fino a meta\u300 estate, ma sono nettamente differenti a fine estate-inizio autunno, quando in Sicilia il clima diviene piu\u300 umido. Da una puntuale analisi dei corrispondenti dati climatici registrati nelle due aree e\u300 infatti emersa una sostanziale differenza nel decorso piu\u300 caldo e secco degli ultimi tre mesi precedenti la raccolta nel Western Cape; questo periodo invece in Sicilia e\u300 caratterizzato da temperature piu\u300 fresche e un aumento dell\u2019umidita\u300 relativa che favorisce l\u2019impennata delle infestazioni di B. oleae. Nei quattro mesi presi in considerazione si rileva anche una significativa differenza nell\u2019escursione termica, maggiore nel Western Cape, dovuta a minime notturne piu\u300 basse. Da un confronto dei livelli di parassitizzazione di B. oleae del Western Cape (Sud Africa) e dell\u2019area costiera della Provincia di Trapani, recentemente registrati su olivo colti- vato e selvatico (Olea europaea subsp. cuspidata in Sud Africa, Olea europaea subsp. europaea var. sylvestris in Sicilia) non sono emerse sostanziali differenze quantitative, pur confer- mando che in Sud Africa i principali parassitoidi sono tre bra- conidi (Utetes africanus (Sze\u301pligeti), Psyttalia lounsburyi (Silvestri) e Bracon celer (Sze\u301pligeti)), con il primo preva- lente sull\u2019olivo selvatico e l\u2019ultimo sul coltivato, mentre in Sicilia il braconide parassitoide Psyttalia concolor (Sze\u301pligeti) prevale sia sull\u2019olivo selvatico che sul coltivato. Comunque in entrambe le aree la parassitizzazione su B. oleae non rag- giunge elevati ed efficaci livelli. Il clima, e non la parassitizzazione dovuta ai braconidi, appare il piu\u300 importante fattore di contenimento di B. oleae anche in Sud Africa. L\u2019introduzione di parassitoidi specifici della mosca delle olive e\u300 necessaria nelle aree colonizzate di recente dove essi mancano, ma i tentativi di fornir loro una maggiore dis- ponibilita\u300 di larve dell\u2019ospite mediante l\u2019impianto di cultivar d\u2019olivo a maturazione e permanenza dei frutti piu\u300 differen- ziata, potrebbe produrre risultati certamente piu\u300 negativi che positivi nei confronti della presenza e dei livelli d\u2019infesta- zione di B. oleae sull\u2019olivo coltivato, come avviene nelle aree pandacie dove cresce spontaneo l\u2019olivastro.Natural environmental control of Bactrocera oleae (Rossi): climate or parasitoids? A comparison between the Western Cape of South Africa and Sicily. Bactrocera oleae (Rossi), the olive fruit fly is considered not a continuosly serious pest of olive trees in the Western Cape of South Africa, in spite of the climate similar to Mediterranean areas. South African braconid parasitoids of B. oleae are more numerous than in Mediterranean areas, and until now their action has been considered the factor lowering the level of infestation due to the olive fruit fly, but no deep studies on its infestation levels and climatic factors influencing them were carried out in the past. Analyzing recent data on infestation levels collected in the Western Cape and Sicily, they appear similar in a regular mid- summer, differing at the end of summer-beginning of autumn, when in Sicily the climate becomes more humid than in the Western Cape. A comparison of climatic data regarding four years underlines that Somerset West and Franshhoek, in comparison with Trapani, have significantly lower minimum daily temperatures, a higher daily thermal excursion and a lower relative humidity in the last three months preceding harvesting. Parasitization rates on B. oleae of Western Cape and Sicily, recorded on both cultivated and wild olives (Olea europaea subsp. cuspidata in South Africa, Olea europaea subsp. europaea var. sylvestris in Sicily) are not substantially different, confirming that in South Africa three braconids, Utetes africanus (Sze\u301pligeti), Psyttalia lounsburyi (Silvestri) and Bracon celer (Sze\u301pligeti), are the main parasitoids, with the first one as leader in wild olives and the last one as leader in cultivated ones, while in Sicily the braconid Psyttalia concolor (Sze\u301pligeti) is the main parasitoid in both wild and cultivated olives. Nevertheless parasitism on B. oleae doesn\u2019t reach effective levels of control in bats ragions. The climate, instead of parasitization due to braconids, is the main environmental factor limiting the olive fruit fly infestations in the Western Cape of South Africa. The introduction of parasitoids specific to the olive fruit fly is necessary in new invaded areas where they lack, but the attempt of providing them a more available amount of host fruits along the year, planting olive trees bearing fruits up to spring, could bring serious problems as those typical of Mediterranean areas where the European wild olive naturally grows

A methodological approach of QRA for slow-moving landslides at a regional scale

Landslides represent a serious worldwide hazard, especially in Italy, where exposure to hydrogeological risk is very high; for this reason, a landslide quantitative risk assessment (QRA) is crucial for risk management and for planning mitigation measures. In this study, we present and describe a novel methodological approach of QRA for slow-moving landslides, aiming at national replicability. This procedure has been applied at the basin scale in the Arno River basin (9100 km(2), Central Italy), where most landslides are slow-moving. QRA is based on the application of the equation risk = hazard (H) × vulnerability (V) × exposure (E) and on the use of open data with uniform characteristics at the national scale. The study area was divided into a grid with a 1 km(2) cell size, and for each cell, the parameters necessary for the risk assessment were calculated. The obtained results show that the total risk of the study area amounts to approximately 7 billion €. The proposed methodology presents several novelties in the risk assessment for the regional/national scale of the analysis, mainly concerning the identification of the datasets and the development of new methodologies that could be applicable over such large areas. The present work demonstrates the feasibility of the methodology and discusses the obtained results

Influence of distance from the host on parasitisation by Psyttalia concolor (Szépligeti) (Hymenoptera: Braconidae)

The olive fruit fly, Bactrocera oleae, is considered the main olive pest worldwide, and has been the target of biological control programmes through the release of the braconid parasitoid Psyttalia concolor. Laboratory tests were performed to evaluate the influence of distance from the host on parasitisation, placing larvae of the substitute host Ceratitis capitata at seven distances (0, 0.5, 1, 1.5, 2, 2.5, 3 mm) and four different time periods (7, 15, 30, 60 min). Moreover, field collected olives of Ogliarola Barese cultivar infested by B. oleae were exposed to P. concolor females to confirm its ability to parasitise B. oleae in small olives. Psyttalia concolor oviposition was inhibited at 2.5 and 3 mm due to the ovipositor length of the parasitoid females (2.7 mm). Hosts were easily parasitised at distances between 0 and 1.5 mm. The thin fruit pulp (up to 3.5 mm) of field collected olives allowed the parasitisation to occur also in mature fruits. At the best combination distance/time (0 mm, 30 min), tests performed with different larvae/parasitoid female ratio showed an increasing emergence of P. concolor (from 20% to 57%) with larvae/parasitoid ratio increasing from 0.11 to 0.74. The results of the present study might optimise the mass rearing of P. concolor, through a proper setting of its parameters, such as the host/parasitoid ratio, exposure distances, and interaction time

Assessing landslide damming susceptibility in Central Asia

Central Asia regions are characterized by active tectonics, high mountain chains with extreme topography with glaciers, and strong seasonal rainfall events. These key predisposing factors make large landslides a serious natural threat in the area, causing several casualties every year. The mountain crests are divided by wide lenticular or narrow, linear intermountain tectonic depressions, which are incised by many of the most important Central Asia rivers and are also subject to major seasonal river flood hazard. This multi-hazard combination is a source of potential damming scenarios, which can bring cascading effects with devastating consequences for the surrounding settlements and population. Different hazards can only be managed with a multi-hazard approach coherent within the different countries, as suggested by the requirements of the Sendai Framework for Disaster Risk Reduction. This work was carried out within the framework of the Strengthening Financial Resilience and Accelerating Risk Reduction in Central Asia (SFRARR) project as part of a multi-hazard approach with the aim of providing a damming susceptibility analysis at a regional scale for Central Asia. To achieve this, a semi-automated GIS-based mapping method, centered on a bivariate correlation of morphometric parameters defined by a morphological index, originally designed to assess the damming susceptibility at basin/regional scale, was modified to be adopted nationwide and applied to spatially assess the obstruction of the river network in Central Asia for mapped and newly formed landslides. The proposed methodology represents an improvement to the previously designed methodology, requiring a smaller amount of data, bringing new preliminary information on damming hazard management and risk reduction, and identifying the most critical area within the Central Asia regions.</p

A morphological, biological and molecular approach reveals four cryptic species of Trissolcus Ashmead (Hymenoptera, Scelionidae), egg parasitoids of Pentatomidae (Hemiptera)

Accurate identification of parasitoids is crucial for biological control of the invasive brown marmorated stink bug, Halyomrpha halys (Stål). A recent work by Talamas et al. (2017) revised the Palearctic fauna of Trissolcus Ashmead, egg-parasitoids of stink bugs, and treated numerous species as junior synonyms of T. semistriatus (Nees von Esenbeck). In the present paper, we provide a detailed taxonomic history and treatment of T. semistriatus and the species treated as its synonyms by Talamas et al. (2017) based on examination of primary types, molecular analyses and mating experiments. Trissolcus semistriatus, T. belenus (Walker), T. colemani (Crawford), and T. manteroi (Kieffer) are here recognized as valid and a key to species is provided. The identification tools provided here will facilitate the use of Trissolcus wasps as biological control agents and as the subject of ecological studies

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

© 2019, The Author(s). Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM (-/-) patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors