2 research outputs found
ΠΠΊΡΠΏΠ½ΠΈ Ρ ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈ β ΠΌΠ°ΡΠΊΠ΅Ρ Π·Π° Π»ΠΈΠΏΠΈΠ΄Π½Π° ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΡΠ° ΠΊΠ°Ρ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ
ΠΠΎΠ²Π΅Π΄
ΠΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΈΠΎΡ ΡΡΡΠ΅Ρ ΠΏΡΠΈΠ΄ΠΎΠ½Π΅ΡΡΠ²Π° Π²ΠΎ ΡΠ°Π·Π²ΠΎΡΠΎΡ Π½Π° Π°ΡΠ΅ΡΠΎΡΠΊΠ»Π΅ΡΠΎΠ·Π°ΡΠ° ΠΈ Π΄ΠΎΠ²Π΅Π΄ΡΠ²Π° Π΄ΠΎ Π½Π΅ΡΡΠ°Π±ΠΈΠ»Π½ΠΎΡΡ Π½Π° ΠΏΠ»Π°ΠΊΠ°ΡΠ° Π²ΠΎ Π²Π°ΡΠΊΡΠ»Π°ΡΠ½ΠΈΠΎΡ ΡΠΈΠ΄. Π‘Π΅ΡΡΠΌΡΠΊΠΈΡΠ΅ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ Π½Π° Π»ΠΈΠΏΠΈΠ΄Π½Π° ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΡΠ°, ΠΊΠ°ΠΊΠΎ ΡΡΠΎ ΡΠ΅ Ρ
ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈΡΠ΅, ΠΌΠΎΠΆΠ΅ Π΄Π° ΠΏΡΠ΅ΡΡΡΠ°Π²ΡΠ²Π°Π°Ρ Π½Π΅Π·Π°Π²ΠΈΡΠ΅Π½ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡ Π·Π° ΡΠΈΠ·ΠΈΠΊ ΠΊΠ°Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΡΠΎ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ (ΠΠΠ).
Π¦Π΅Π»
ΠΠ° ΡΠ΅ ΠΈΡΠΏΠΈΡΠ° Π΄Π°Π»ΠΈ ΠΏΠΎΡΡΠΎΠΈ ΡΠ°Π·Π»ΠΈΠΊΠ° Π²ΠΎ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠ°ΡΠ° Π½Π° Ρ
ΠΈΠ΄ΡoΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈΡΠ΅ Π²ΠΎ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠ°, ΠΏΠΎΠΌΠ΅ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ ΡΠΎ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ ΠΈ Π·Π΄ΡΠ°Π²ΠΈ ΠΊΡΠ²ΠΎΠ΄Π°ΡΠΈΡΠ΅Π»ΠΈ.
ΠΠ°ΡΠ΅ΡΠΈΡΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈ
ΠΡΠΏΠΈΡΡΠ²Π°ΡΠ΅ΡΠΎ ΠΏΡΠ΅ΡΡΡΠ°Π²ΡΠ²Π° ΠΏΡΠ΅ΡΠ΅ΡΠ½Π° ΡΡΡΠ΄ΠΈΡΠ° Π²ΠΎ ΠΊΠΎΡΠ° ΡΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈ 300 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ, ΠΏΠΎΠ΄Π΅Π»Π΅Π½ΠΈ Π²ΠΎ Π΄Π²Π΅ Π³ΡΡΠΏΠΈ: ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ ΡΠΎ Π°ΠΊΡΡΠ½Π° ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ ΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ½Π° (ΠΈΡΡ
Π΅ΠΌΠΈΡΠ½Π°) Π±ΠΎΠ»Π΅ΡΡ Π½Π° ΡΡΡΠ΅ΡΠΎ, ΡΠΎ ΡΠΎΠΎΠ΄Π²Π΅ΡΠ½ΠΈ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΈ. ΠΡΠΈΠΌΠ΅ΡΠΎΡΠΈΡΠ΅ ΡΠ΅ ΠΎΠ±ΡΠ°Π±ΠΎΡΡΠ²Π°Π½ΠΈ Π²ΠΎ Π±ΠΈΠΎΡ
Π΅ΠΌΠΈΡΠΊΠ°ΡΠ° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΡΠ° ΠΏΡΠΈ ΡΡΠΎ Π΅ ΠΊΠΎΡΠΈΡΡΠ΅Π½ ΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠΊΠΈ ΡΠ΅ΡΡ Π·Π° ΠΊΠ²Π°Π½ΡΠΈΡΠ°ΡΠΈΠ²Π½ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ²Π°ΡΠ΅ Π½Π° Π²ΠΊΡΠΏΠ½ΠΈΡΠ΅ Ρ
ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈ Π²ΠΎ ΠΊΡΠ²Π½Π° ΠΏΠ»Π°Π·ΠΌΠ°, Π° Π·Π° ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΡΠ° Π½Π° ΡΠ΅Π·ΡΠ»ΡΠ°ΡΠΈΡΠ΅ ΡΠ΅ ΠΊΠΎΡΠΈΡΡΠ΅Π½ΠΈ ΡΡΠ°Π½Π΄Π°ΡΠ΄Π½ΠΈ ΡΠ΅ΡΠ΅ΡΠ΅Π½ΡΠ½ΠΈ Π²ΡΠ΅Π΄Π½ΠΎΡΡΠΈ.
Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈ
ΠΠΎΠ±ΠΈΠ΅Π½ΠΈΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΠ°ΡΠΈ ΡΠΊΠ°ΠΆΡΠ²Π°Π°Ρ Π½Π° ΡΡΠ°ΡΠΈΡΡΠΈΡΠΊΠΈ Π·Π½Π°ΡΠ°ΡΠ½Π° ΡΠ°Π·Π»ΠΈΠΊΠ° Π²ΠΎ ΠΎΠ΄Π½ΠΎΡ Π½Π° ΡΡΠ΅Π΄Π½ΠΈΡΠ΅ Π²ΡΠ΅Π΄Π½ΠΎΡΡΠΈ Π½Π° ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠ°ΡΠ° Π½Π° Ρ
ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈΡΠ΅ ΠΊΠ°Ρ ΠΈΡΠΏΠΈΡΠ°Π½ΠΈΡΠΈΡΠ΅ ΡΠΎ ΠΈ Π±Π΅Π· ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ, Π½ΠΎ Π½Π΅ΠΏΠΎΡΡΠΎΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠΊΠΈ Π·Π½Π°ΡΠ°ΡΠ½Π° ΡΠ°Π·Π»ΠΈΠΊΠ° ΠΌΠ΅ΡΡ ΠΈΡΠΏΠΈΡΠ°Π½ΠΈΡΠΈΡΠ΅ ΡΠΎ Π°ΠΊΡΡΠ½Π° ΠΈ ΡΠΎ Ρ
ΡΠΎΠ½ΠΈΡΠ½Π° ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ, Π½ΠΈΡΡ ΠΏΠ°ΠΊ ΠΌΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠ°Π½ΠΈΡΠ΅ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΈ Π½Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ.
ΠΠ°ΠΊΠ»ΡΡΠΎΠΊ
Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈΡΠ΅ ΡΠΊΠ°ΠΆΡΠ²Π°Π°Ρ Π½Π° Π·Π³ΠΎΠ»Π΅ΠΌΠ΅Π½ΠΎ Π½ΠΈΠ²ΠΎ Π½Π° Π²ΠΊΡΠΏΠ½ΠΈΡΠ΅ Ρ
ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΠΈ Π²ΠΎ ΠΊΡΠ²Π½Π°ΡΠ° ΠΏΠ»Π°Π·ΠΌΠ° ΠΊΠ°Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ ΡΠΎ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½Π° Π°ΡΡΠ΅ΡΠΈΡΠΊΠ° Π±ΠΎΠ»Π΅ΡΡ ΡΡΠΎ ΡΠΊΠ°ΠΆΡΠ²Π° Π½Π° ΠΏΠΎΡΡΠΎΡΠ΅ Π½Π° ΡΠ΅Π΄ΠΎΠΊΡ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ Π²ΠΎ ΡΠΏΠΎΡΠ΅Π΄Π±Π° ΡΠΎ Π·Π΄ΡΠ°Π²ΠΈΡΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈ. ΠΠΎΡΡΠ΅Π±Π½ΠΎ Π΅, Π²ΠΎ ΠΈΠ΄Π½ΠΈΠ½Π°, ΠΎΠ²ΠΈΠ΅ Π°Π½Π°Π»ΠΈΠ·ΠΈ Π΄Π° ΡΠ΅ ΠΊΠΎΡΠΈΡΡΠ°Ρ ΠΊΠ°ΠΊΠΎ Π΄Π΅Π» ΠΎΠ΄ ΠΏΠ°Π½Π΅Π»ΠΎΡ Π½Π° Π²Π΅ΡΠ΅ ΠΏΠΎΠ·Π½Π°ΡΠΈ ΠΈ/ΠΈΠ»ΠΈ Π½ΠΎΠ²ΠΈ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΈ ΡΠΎ ΡΠ΅Π» ΡΠΎΠΎΠ΄Π²Π΅ΡΠ½ΠΎ Π΄Π° ΡΠ΅ Π΄Π΅Π»ΡΠ²Π° ΠΊΠΎΠ½ ΠΏΡΠ΅Π²Π΅Π½ΡΠΈΡΠ° ΠΈΠ»ΠΈ ΠΎΠ΄ΡΠ΅Π΄Π΅Π½ ΡΡΠ΅ΡΠΌΠ°Π½ ΠΏΡΠΈ Π»Π΅ΠΊΡΠ²Π°ΡΠ΅ΡΠΎ Π½Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΡΠΎ ΠΠΠ
Heroin Dependence Duration Influences the Metabolic Parameters Mechanisms and Consequences of Impaired Insulin Sensitivity in Hepatitis C Virus Seronegative Heroin Dependents
Objective: Carbohydrate metabolism disorder in heroin dependence is an issue with long history and contradicting results. The aim of the study was to evaluate basal insulin sensitivity in hepatitis C virus seronegative heroin dependents with normal body mass index, taking into consideration the duration of heroin dependence.
Method: 78 heroin dependents and 32 healthy controls were enrolled in the cross-sectional, prospective study. The dependents were observed in 2 groups: group 1 with dependence duration less than or equal to 3 years and group 2 with more than 3 years. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Ξ²-cell function (HOMA-B%) were used to define basal glucoseinsulin homeostasis.
Results: The group with longer dependence duration had HOMAIR(2.23 Β± 3.15) significantly higher compared with the control group (1.23 Β± 0.53, P = 0.016) but lower compared with the group with the shorter dependence duration (2.65 Β± 2.66, P = 0.024), after adjustment for HOMA-B%, waist circumference, and aspartate aminotransferase. The decrease in HOMA-IR during prolonged heroin addiction was significantly associated with the reduced Ξ²-cell function (P < 0.001) and waist circumference (P = 0.004).
Conclusions: Heroin dependence is associated with increased insulin resistance in hepatitis C virus seronegative heroin dependents.Prolonged heroin use is associated with reduction of basal Ξ²-cell pancreatic function with decreased insulin resistance controlled for waist circumference, but still inducing significantly decreased basal insulin sensitivity.
Key Words: dependence duration, heroin, HOMA-B%, HOMA-I