Ojibwe and Canis Lupus : cultural, historical, and political influences on contemporary wolf management in the Great Lakes region

My thesis examines the relationship between the Ojibwe and the gray wolf (Canis lupus) by examining the historical, cultural, and political contexts that have shaped how Ojibwe currently view the wolf. I compare this relationship with the contemporary management of the wolf by federal and state governments. I conclude that the relationship between the Ojibwe and the wolf is complex, and draws on the cultural significance of the wolf to the Ojibwe, yet is also impacted by other driving factors. The Ojibwe management of the wolf contrasts with state management, and thus, Ojibwe have the opportunity to provide differing management strategies and influence how gray wolves will continue to recover throughout Wisconsin, and the rest of the western Great Lakes states

The Role of Social Context in Modulating Gene Expression, Neural Activity, and Neuroendocrine Response in Individuals of Varying Social Status

Social context, which includes both the direct social experience of individuals as well as the characteristics of their social network as a whole, has been shown to be an important modulator of behavior across species. However, relatively little is known about the role of social context in regulating the complex relationships between neurobiology, neuroendocrine response, and behavior in mammals. Historically, the neurobiology of social behavior has been studied at the dyadic level, looking at brief social interactions between pairs of individuals. Given that all social species live in groups, rather than pairs, it is essential that we begin to understand the role social context at the group level plays in regulating physiology. Throughout this thesis, I use a novel behavioral housing system to study how the characteristics of stable social groups and how instances of social opportunity, when individuals are ascending up a social hierarchy, are associated with differential brain gene expression, neuroendocrine output, and behavior. I first extensively analyze the social dynamics of male dominance hierarchies, showing that they are both consistent, in that males reliably form significantly linear dominance hierarchies, and unique, in that the characteristics of these hierarchies vary from group to group. I further prove that mice living in these social hierarchies are extremely socially competent, displaying the ability to respond appropriately to individuals of varying social status. I demonstrate that females are capable of forming dominance hierarchies as well, but that their hierarchies differ from those of males. I then use this foundational knowledge to investigate how these different hierarchy characteristics can lead to differences in physiology, how one’s social status is associated with brain gene expression and neuroendocrine response, and how disruption of a hierarchy through removal of the alpha male leads to robust behavioral as well as physiological consequences. Finally, I use the insights gained from this immediate early gene work to demonstrate the crucial role of the infralimbic/prelimbic region of the medial prefrontal cortex in regulating socially competent response to changing social contexts. Taken together, this work establishes the broad role social context plays in regulating the complex relationships between behavior, brain gene expression, neural activation, and neuroendocrine output

Examining Parental Stress in Incarcerated Setting

Examining Parental Stress in Incarcerated Setting Henson, C., Williamson, A., Holland, T., & Tiano, J. The majority of literature on incarcerated parenting styles and parental stress has focused primarily on mothers, with very little research conducted with fathers. Research has found that mothers report more parenting stress on the Parenting Stress Index (PSI) than fathers. In response to limited research in this area, the current study used preliminary data from a larger study to examine the correlation between parenting stress and various demographic variables (i.e. age, number of children, number of contact hours with children while incarcerated, number of contact hours with children while not incarcerated) with males and females in an incarcerated setting. Eight males and eleven females completed the PSI 4th Edition Long Form and a demographic form as part of a larger study. Results and implications of results will be discussed

The Effect of Family-Work Biases on Women's Promotions

This thesis examines the role of family-work biases in women’s promotions to upper-level management positions. Women are proportionately represented in entry-level and middle-management positions when compared to their male counterparts. However, women are disproportionately underrepresented in upper-management positions despite ever-increasing numbers of women entering the workforce. My study revealed correlations between what men and women perceive regarding family-work biases and how family obligations actually affect them or others they know. I discovered that mothers, more than fathers, were perceived to have family obligations that hold them back in the workplace; however, I found no correlation between the degree of family-work conflicts a person experienced and whether or not he or she was promoted. In addition, data analysis showed that women with children received fewer promotions than women without children.Bachelor of Scienc

The Prospective Role of Cognitive Appraisals and Social Support in Predicting Children's Posttraumatic Stress.

Although both social support and cognitive appraisals are strong predictors of children's posttraumatic adjustment, understanding of the interplay between these factors is limited. We assessed whether cognitive appraisals mediated the relationship between social support and symptom development, as predicted by cognitive models of posttraumatic stress disorder (PTSD). Ninety seven children (Mean age = 12.08 years) were assessed at one month and six months following a single incident trauma. We administered self-report measures of cognitive appraisals, social support, and a diagnostic interview for PTSD. Results indicated that cognitive appraisals at one month post-trauma mediated the relationship between social support at one month post-trauma, and PTSD severity at follow-up. Differences in this relationship were observed between child-reported social support and parent-rated ability to provide support. Firm evidence was provided for the application of cognitive models of PTSD to children

XO-2b: a hot Jupiter with a variable host star that potentially affects its measured transit depth

The transiting hot Jupiter XO-2b is an ideal target for multi-object photometry and spectroscopy as it has a relatively bright ($V$-mag = 11.25) K0V host star (XO-2N) and a large planet-to-star contrast ratio (R$_{p}$/R$_{s}\approx0.015$). It also has a nearby (31.21") binary stellar companion (XO-2S) of nearly the same brightness ($V$-mag = 11.20) and spectral type (G9V), allowing for the characterization and removal of shared systematic errors (e.g., airmass brightness variations). We have therefore conducted a multiyear (2012--2015) study of XO-2b with the University of Arizona's 61" (1.55~m) Kuiper Telescope and Mont4k CCD in the Bessel U and Harris B photometric passbands to measure its Rayleigh scattering slope to place upper limits on the pressure-dependent radius at, e.g., 10~bar. Such measurements are needed to constrain its derived molecular abundances from primary transit observations. We have also been monitoring XO-2N since the 2013--2014 winter season with Tennessee State University's Celestron-14 (0.36~m) automated imaging telescope to investigate stellar variability, which could affect XO-2b's transit depth. Our observations indicate that XO-2N is variable, potentially due to {cool star} spots, {with a peak-to-peak amplitude of $0.0049 \pm 0.0007$~R-mag and a period of $29.89 \pm 0.16$~days for the 2013--2014 observing season and a peak-to-peak amplitude of $0.0035 \pm 0.0007$~R-mag and $27.34 \pm 0.21$~day period for the 2014--2015 observing season. Because of} the likely influence of XO-2N's variability on the derivation of XO-2b's transit depth, we cannot bin multiple nights of data to decrease our uncertainties, preventing us from constraining its gas abundances. This study demonstrates that long-term monitoring programs of exoplanet host stars are crucial for understanding host star variability.Comment: published in ApJ, 9 pages, 11 figures, 3 tables; updated figures with more ground-based monitoring, added more citations to previous work

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells

Introduction: Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells representative of all three germ line layers. The aim of this study was to determine the potential of USSC to form definitive endoderm following induction with Activin A, a protein known to specify definitive endoderm formation of hESC. Methods: USSC were cultured for (1) three days with or without 100 ng/ml Activin A in either serum-free, low-serum or serum-containing media, (2) three days with or without 100 ng/ml Activin A in combination with 10 ng/ml FGF4 in pre-induction medium, or (3) four days with or without small molecules Induce Definitive Endoderm (IDE1, 100 nM; IDE2, 200 nM) in serum-free media. Formation of definitive endoderm was assessed using RT-PCR for gene markers of endoderm (Sox17, FOXA2 and TTF1) and lung epithelium (surfactant protein C; SPC) and cystic fibrosis transmembrane conductance regulator; CFTR). The differentiation capacity of Activin A treated USSC was also assessed. Results: Activin A or IDE1/2 induced formation of Sox17+ definitive endoderm from hESC but not from USSC. Activin A treated USSC retained their capacity to form cells of the ectoderm (nerve), mesoderm (bone) and endoderm (lung). Activin A in combination with FGF4 did not induce formation of Sox17+ definitive endoderm from USSC. USSC express both Activin A receptor subunits at the mRNA and protein level, indicating that these cells are capable of binding Activin A. Conclusions: Stimulation of the Nodal signaling pathway with Activin A or IDE1/2 is insufficient to induce definitive endoderm formation from USSC, indicating that USSC differ in their stem cell potential from hESC

Termination of wanted pregnancy and suicidal ideation in hyperemesis gravidarum : a mixed methods study

Background Difficulty accessing medication and poor patient experience have been implicated as risk factors for termination of pregnancy and suicidal ideation in women with hyperemesis gravidarum. We aimed to gain further insight into these factors in order to further inform and improve patient care. Methods We performed a sub-analysis on quantitative data generated through a UK-wide survey of 5071 participants. A qualitative analysis of free text comments was performed using an inductive thematic approach. Results 41.2% % of women taking prescribed medications had to actively request them. 'Extremely poor' or 'poor' experiences were described in 39.4% and 30.0% of participants in primary and secondary care respectively. Protective factors for termination of pregnancy and suicidal ideation include holistic support from family, friends and healthcare providers. Conclusion Optimal care in hyperemesis gravidarum should incorporate timely access to pharmacotherapy, assessment of mental health, consideration of referral to specialist services and care being delivered in a compassionate manner

Baseline characteristics of people experiencing homelessness with a recent drug overdose in the PHOENIx pilot randomised controlled trial

Background: Drug-related deaths in Scotland are the highest in Europe. Half of all deaths in people experiencing homelessness are drug related, yet we know little about the unmet health needs of people experiencing homelessness with recent non-fatal overdose, limiting a tailored practice and policy response to a public health crisis. Methods: People experiencing homelessness with at least one non-fatal street drug overdose in the previous 6 months were recruited from 20 venues in Glasgow, Scotland, and randomised into PHOENIx plus usual care, or usual care. PHOENIx is a collaborative assertive outreach intervention by independent prescriber NHS Pharmacists and third sector homelessness workers, offering repeated integrated, holistic physical, mental and addictions health and social care support including prescribing. We describe comprehensive baseline characteristics of randomised participants. Results: One hundred and twenty-eight participants had a mean age of 42 years (SD 8.4); 71% male, homelessness for a median of 24 years (IQR 12–30). One hundred and eighteen (92%) lived in large, congregate city centre temporary accommodation. A quarter (25%) were not registered with a General Practitioner. Participants had overdosed a mean of 3.2 (SD 3.2) times in the preceding 6 months, using a median of 3 (IQR 2–4) non-prescription drugs concurrently: 112 (87.5%) street valium (benzodiazepine-type new psychoactive substances); 77 (60%) heroin; and 76 (59%) cocaine. Half (50%) were injecting, 50% into their groins. 90% were receiving care from Alcohol and Drug Recovery Services (ADRS), and in addition to using street drugs, 90% received opioid substitution therapy (OST), 10% diazepam for street valium use and one participant received heroin-assisted treatment. Participants had a mean of 2.2 (SD 1.3) mental health problems and 5.4 (SD 2.5) physical health problems; 50% received treatment for physical or mental health problems. Ninety-one per cent had at least one mental health problem; 66% had no specialist mental health support. Participants were frail (70%) or pre-frail (28%), with maximal levels of psychological distress, 44% received one or no daily meal, and 58% had previously attempted suicide. Conclusions: People at high risk of drug-related death continue to overdose repeatedly despite receiving OST. High levels of frailty, multimorbidity, unsuitable accommodation and unmet mental and physical health care needs require a reorientation of services informed by evidence of effectiveness and cost-effectiveness. Trial registration UK Clinical Trials Registry identifier: ISRCTN 10585019