An IgE immediate reaction to thiocolchicoside.

Hypersensitivity reactions due to muscle relaxant drugs may be related either to a nonspecific release of allergic mediators or to allergic reactions induced by the molecules themselves. Rare cases of hypersensitivity reactions have been associated to thiocolchicoside, and no case of IgE-mediated immediate reaction has actually been reported to date. We report the first documented case of immediate anaphylaxis to thiocolchicoside

Towards the development of a MEMS-based health monitoring system for lightweight structures

We recently proposed a surface-mounted structural health monitoring (SHM) scheme based on commercial, low-cost inertial MEMS sensors. While such commercial-off-the-shelf sensors are not very accurate, their low cost and negligible weight allow them to be deployed in dense arrays, possibly overcoming inaccuracy through redundancy. Taking the sensor characteristics into account, the development of a MEMS-based SHM method for lightweight structures like thin plates, is tackled from two different viewpoints: sensor accuracy verification, and optimal sensor placement. To assess the accuracy, a preliminary investigation was run on standard composite specimens for delamination testing, adopting a single MEMS three-axis accelerometer. A theoretical interpretation of the results, based on beam bending theory, showed the ability of the system to provide a one-to-one relationship between the delamination length and the sensor output. Concerning the placement of the sensors, an approach for their optimal deployment was developed, using a topology optimization-like formulation. Such formulation looks for the optimal layout of the network by maximizing the overall sensitivity of the output to a damage possibly located anywhere. In this work, accounting for the characteristic sizes of a structural element and of the MEMS package, which might differ by orders of magnitude, we introduce a multi-scale (actually, two-scale) approach to sensor deployment. It is shown that, no matter what the location and size of the damaged area are, a trivial array of evenly spaced sensors does not represent the optimal solution for SHM

On compressive radial tidal forces

Radial tidal forces can be compressive instead of disruptive, a possibility that is frequently overlooked in high level physics courses. For example, radial tidal compression can emerge in extended stellar systems containing a smaller stellar cluster. For particular conditions the tidal field produced by this extended mass distribution can exert on the cluster it contains compressive effects instead of the common disruptive forces. This interesting aspect of gravity can be derived from standard relations given in many textbooks and introductory courses in astronomy and can serve as an opportunity to look closer at some aspects of gravitational physics, stellar dynamics, and differential geometry. The existence of compressive tides at the center of huge stellar systems might suggest new evolutionary scenarios for the formation of stars and primordial galactic formation processes.Comment: 22 pages, 2 figure

A 3D Numerical Model for the Optimization of Running Tracks Performance

In previous works, a finite element model of the shock absorbing characteristics of athletics tracks was developed, able to give sufficiently reliable predictions from laboratory tests performed on suitable material samples. The model proved to be effective in discriminating the effects of geometry (i.e. thickness) and material properties (essentially the elastic characteristics) on force reduction, thus allowing a first optimization of the tracks in view of their approval by the International Association of Athletics Federations (IAAF). This simplified 2D model neglected the real track structure, considering it as a single layer of material having homogenized properties. In the present study, a new 3D model was developed to accurately describe the structure of multi-layered tracks, with properties and geometrical construction (e.g. solid or honeycomb) differing from one layer to another. Several tracks having different combinations of top/bottom layers varying in both material formulation (i.e. chemical composition) and geometry were thus considered. Mechanical properties of the individual elements constituting the track were measured with small-scale laboratory tests, taking into account their strain-rate dependence. The 3D model allowed a complete representation of the loads acting on the track and it gave results which are in very good agreement with the experiments. This proves it to be a valuable tool for the purpose of optimizing the track in terms of material formulation as well as layer geometrical construction and arrangement: as an example, the effect of changing the cell size of the honeycomb pattern was investigated

Towards Safer Helmets: Characterisation, Modelling and Monitoring

Bike and ski helmets are mainly made up of two layers: the external shell and the foam liner. The foam liner, typically made of expanded polystyrene (EPS) or polypropylene (EPP), is asked to provide energy absorption in case of impacts. Standard helmet design requires the foam to maximize this energy absorption, thus achieving large deformations (up to 25% in compression) while maintaining the stress level below a threshold value. To optimize the helmet construction in terms of foam composition, structure and density, reliable numerical models are required, which in turn need to be fed with accurate experimental data. A characterisation of several foams was performed, including EPS and EPP having varying densities, under tensile and compressive stress states at varying strain rates. Typical mechanical parameters (elastic moduli and plateau stress in compression, Poisson's ratio) were compared with literature data and applicability of existing models to experimental results was discussed. A marked strain rate dependence – very important for impact applications – was accurately described using the Nagy phenomenological model. The foam microstructure was investigated using scanning electron microscopy (SEM) to assess structural changes before and after compression. The aforementioned mechanical features were then adopted in a rate-dependent constitutive law for crushable foams, to model the shock attenuation properties of helmets and validate the approach against available data. Finally, a microelectromechanical system based in-helmet wireless micro monitoring system was developed and inserted in a helmet prototype. The system is capable of acquiring impact load spectra, providing valuable information to investigate generic impacts with varying angles and energy. In particular, it can monitor the effect of repeated micro-impacts on the residual energy absorption characteristics of the foam

Vitamin D and rheumatic diseases.

Vitamin D has some well-known effects on calcium, phosphate and bone metabolism, but it has recently shown to have many other effects, which may potentially be relevant to patients with extra-skeletal rheumatic diseases. Such effects may be justified by: 1) the presence of the vitamin D receptors also on extra-osseous cells, such as cartilage cells, sinoviocytes, muscle cells; 2) the proven role of vitamin D in the control of the transcription of genes involved in rheumatic diseases; 3) the evidence that vitamin D has multiple endocrine effects not only on calcium homeostasis; 4) the activation of vitamin D not only in the kidneys, but also in monocyte-macrophage and lymphocytic cell lines and in some epithelial cells with additional intracrine and paracrine effects. Vitamin D deficiency has been reported in numerous metabolic, degenerative, inflammatory and autoimmune rheumatic diseases. In some cases this association was also related to the risk of developing a rheumatic disease or the degree of disease activity. However there is no conclusive evidence of the efficacy of a preventive or therapeutic strategy based on vitamin D supplementation in extra-skeletal rheumatic diseases. This review aims to provide an overview of the latest evidence concerning the relationship between vitamin D and the most relevant rheumatic diseases

Role of air pollutants mediated oxidative stress in respiratory diseases

Airborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidative potential of PM2.5 can be evaluated with the dithiothreitol (DTT) dosage, which represents both ROS chemically produced and intracellular ROS of macrophages. This correlates with quality indicators of the internal environment and ventilation strategies such as dilution and removal of airborne contaminants

Covid-19 vaccines in children with cow’s milk and food allergies

The COVID-19 pandemic is the most challenging global health crisis of our times. Vaccination against COVID-19 plays a key role to control the current pandemic situation. The risk of allergic reactions to new COVID-19 vaccines is low. However, there is a debate on the safety in allergic patients following post marketing findings by different agencies. Our aim is to understand from current experiences whether children with cow’s milk or food allergy are at higher risk than a general population for allergic reactions to COVID-19 vaccines. Current data indicate that patients with a history of allergy to cow’s milk or other foods, even if severe, should receive COVID-19 vaccine in a setting with availability of treatments for anaphylactic reactions and under medical supervision. Recipients should be discharged after a protracted observation period of 30 min if no reaction developed

Is it possible to make a diagnosis of raw, heated and baked egg allergy in children using cut-offs? A systematic review

The diagnosis of IgE-mediated egg allergy lies both on a compatible clinical history and on the results of skin prick tests (SPTs) and IgEs levels. Both tests have good sensitivity but low specificity. For this reason, oral food challenge (OFC) is the ultimate gold standard for the diagnosis. The aim of the present paper is to systematically review the literature in order to identify, analyze and synthesize the predictive value of SPT and specific IgEs both to egg white and main egg allergens and to review the cut-offs suggested in the literature