6,742 research outputs found
Ecg-based prediction algorithm for imminent malignant ventricular arrhythmias using decision tree
Spontaneous prediction of malignant ventricular arrhythmia (MVA) is useful to avoid delay in rescue operations. Recently, researchers have developed several algorithms to predict MVA using various features derived from electrocardiogram (ECG). However, there are several unresolved issues regarding MVA prediction such as the effect of number of ECG features on a prediction remaining unclear, possibility that an alert for occurring MVA may arrive very late and uncertainty in the performance of the algorithm predicting MVA minutes before onset. To overcome the aforementioned problems, this research conducts an in-depth study on the number and types of ECG features that are implemented in a decision tree classifier. In addition, this research also investigates an algorithm’s execution time before the occurrence of MVA to minimize delays in warnings for MVA. Lastly, this research aims to study both the sensitivity and specificity of an algorithm to reveal the performance of MVA prediction algorithms from time to time. To strengthen the results of analysis, several classifiers such as support vector machine and naive Bayes are also examined for the purpose of comparison study. There are three phases required to achieve the objectives. The first phase is literature review on existing relevant studies. The second phase deals with design and development of four modules for predicting MVA. Rigorous experiments are performed in the feature selection and classification modules. The results show that eight ECG features with decision tree classifier achieved good prediction performance in terms of execution time and sensitivity. In addition, the results show that the highest percentage for sensitivity and specificity is 95% and 90% respectively, in the fourth 5-minute interval (15.1 minutes–20 minutes) that preceded the onset of an arrhythmia event. Such results imply that the fourth 5-minute interval would be the best time to perform prediction
Conformally rescaled spacetimes and Hawking radiation
We study various derivations of Hawking radiation in conformally rescaled
metrics. We focus on two important properties, the location of the horizon
under a conformal transformation and its associated temperature. We find that
the production of Hawking radiation cannot be associated in all cases to the
trapping horizon because its location is not invariant under a conformal
transformation. We also find evidence that the temperature of the Hawking
radiation should transform simply under a conformal transformation, being
invariant for asymptotic observers in the limit that the conformal
transformation factor is unity at their location.Comment: 22 pages, version submitted to journa
Quantum Spinon Oscillations
The full quantum dynamics of a spinon under external magnetic fields is
investigated by using the time-evolving block decimation (TEBD) method within
the microcanonical picture of transport. We show that the center of the spinon
oscillates back and forth in the absence of dissipation. The quantum many-body
behavior can be understood in a single-particle picture of transport and Bloch
oscillations, where quantum fluctuations induce finite life times. Transport,
oscillations and lifetimes can be tuned to some degree separately by external
fields. Other nontrivial dynamics such as resonance as well as chaos have also
been discussed.Comment: 4.2 pages, 7 figure
Revisiting vertical structure of neutrino-dominated accretion disks: Bernoulli parameter, neutrino trapping and other distributions
We revisit the vertical structure of neutrino dominated accretion flows
(NDAFs) in spherical coordinates with a new boundary condition based on the
mechanical equilibrium. The solutions show that NDAF is significantly thick.
The Bernoulli parameter and neutrino trapping are determined by the mass
accretion rate and the viscosity parameter. According to the distribution of
the Bernoulli parameter, the possible outflow may appear in the outer region of
the disk. The neutrino trapping can essentially affect the neutrino radiation
luminosity. The vertical structure of NDAF is like a "sandwich", and the
multilayer accretion may account for the flares in gamma-ray bursts.Comment: 7 pages, 2 figures, Accepted for publication in Astrophysics & Space
Scienc
Hamilton-Jacobi Tunneling Method for Dynamical Horizons in Different Coordinate Gauges
Previous work on dynamical black hole instability is further elucidated
within the Hamilton-Jacobi method for horizon tunneling and the reconstruction
of the classical action by means of the null-expansion method. Everything is
based on two natural requirements, namely that the tunneling rate is an
observable and therefore it must be based on invariantly defined quantities,
and that coordinate systems which do not cover the horizon should not be
admitted. These simple observations can help to clarify some ambiguities, like
the doubling of the temperature occurring in the static case when using
singular coordinates, and the role, if any, of the temporal contribution of the
action to the emission rate. The formalism is also applied to FRW cosmological
models, where it is observed that it predicts the positivity of the temperature
naturally, without further assumptions on the sign of the energy.Comment: Standard Latex document, typos corrected, refined discussion of
tunneling picture, subsection 5.1 remove
Tunnelling Methods and Hawking's radiation: achievements and prospects
The aim of this work is to review the tunnelling method as an alternative
description of the quantum radiation from black holes and cosmological
horizons. The method is first formulated and discussed for the case of
stationary black holes, then a foundation is provided in terms of analytic
continuation throughout complex space-time. The two principal implementations
of the tunnelling approach, which are the null geodesic method and the
Hamilton-Jacobi method, are shown to be equivalent in the stationary case. The
Hamilton-Jacobi method is then extended to cover spherically symmetric
dynamical black holes, cosmological horizons and naked singularities. Prospects
and achievements are discussed in the conclusions.Comment: Topical Review commissioned and accepted for publication by
"Classical and Quantum Gravity". 101 pages; 6 figure
State transfer in dissipative and dephasing environments
By diagonalization of a generalized superoperator for solving the master
equation, we investigated effects of dissipative and dephasing environments on
quantum state transfer, as well as entanglement distribution and creation in
spin networks. Our results revealed that under the condition of the same
decoherence rate , the detrimental effects of the dissipative
environment are more severe than that of the dephasing environment. Beside
this, the critical time at which the transfer fidelity and the
concurrence attain their maxima arrives at the asymptotic value
quickly as the spin chain length increases. The transfer
fidelity of an excitation at time is independent of when the system
subjects to dissipative environment, while it decreases as increases when
the system subjects to dephasing environment. The average fidelity displays
three different patterns corresponding to , and . For
each pattern, the average fidelity at time is independent of when the
system subjects to dissipative environment, and decreases as increases when
the system subjects to dephasing environment. The maximum concurrence also
decreases as increases, and when , it arrives at an
asymptotic value determined by the decoherence rate and the structure
of the spin network.Comment: 12 pages, 6 figure
Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we demonstrated that p21 is a key determinant of how cells respond to the combination of DNA damage and Chk1 inhibition (combination therapy) in normal cells as well as in tumors. Loss of p21 sensitized normal cells to the combination therapy much more than did p53 loss and the enhanced lethality was partially blocked by CDK inhibition. In addition, basal pools of p21 (p53 independent) provided p53 null cells with protection from the combination therapy. Our results uncover a novel p53-independent function for p21 in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition. As p21 levels are low in a significant fraction of colorectal tumors, they are predicted to be particularly sensitive to the combination therapy. Results reported in this study support this prediction
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