Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry

Treatment and reuse of the wastewater of bean products with the phytosynthetic bacteria and Spirulina maxima

A try on the treatment and reuse of the waste water of bean products with the phytosynthetic bacteria(PSB) and S.maxima(SM)was introduced.First the waste water of bean products was treated with PSB to decompositing organic matter,and then chitin was added for precipitating PSB,the last SM was added into the treated waste water for removing organic matter further and reusing nitrogen and phosphorous.The results of an dynamic modled experiment showed that PSB have a high removal efficiency for COD(70%) on the waste water of bean products,and SM cultured in the treated waste waster grow well,the rate of growing is 2030mg dryweight/(Ld),and the content of protein and free amino acid in SM are 52.6g/100g dryweight and 2.41g/100g dryweight respectively