Neoproterozoic subduction along the Ailaoshan zone, South China : geochronological and geochemical evidence from amphibolite

This study was supported by China Natural Science Foundation (41190073 and 41372198), National Basic Research Program of China (2014CB440901) and Natural Environment Research Council (grant NE/J021822/1).Lenses of amphibolites occur along the Ailaoshan suture zone at the southwestern margin of the Yangtze Block, South China. Petrological, geochemical and zircon U-Pb geochronological data indicate that they are divisible into two coeval groups. Group 1, represented by the Jinping amphibolite, has mg-number of 71-76 and (La/Yb)cn ratios of 7.2-7.7, and displays a geochemical affinity to island arc volcanic rocks. Group 2 amphibolites occur at Yuanyang and are characterized by high Nb contents (14.3-18.4 ppm), resembling Nb-enriched basalts. The epsilon(Nd)(t) values for Group 1 range from -3.45 to -2.04 and for Group 2 from +4.08 to +4.39. A representative sample for Group 1 yields a U-Pb zircon age of 803 7 Ma, whereas two samples for Group 2 give U-Pb zircon ages of 813 +/- 11 Ma and 814 +/- 12 Ma. Petrogenetic analysis suggests that Group 1 originated from an orthopyroxene-rich source and Group 2 from a mantle wedge modified by slab-derived melt. In combination with other geological observations, these amphibolites are inferred to constitute part of an early Neoproterozoic (similar to 815-800 Ma) arc-back-arc basin system. The Neoproterozoic amphibolites and related rocks along the Ailaoshan zone may be the southward extension of the Neoproterozoic supra-subduction zone that developed along the western margin of the Yangtze Block. (C) 2014 Elsevier B.V. All rights reserved.PostprintPeer reviewe

Neoproterozoic crustal growth of the Southern Yangtze Block : Geochemical and zircon U–Pb geochronological and Lu-Hf isotopic evidence of Neoproterozoic diorite from the Ailaoshan zone

This study was supported by National Natural Science Foundation of China (41190073 and 41372198), National Basic Research Program of China (2014CB440901), Basic Operation Expense of Sun Yat-Sen University and Startup Foundation for Doctors of Guilin University of Technology (002401003475).Abstract Neoproterozoic felsic igneous rocks associated with mafic-ultramafic bodies along the margins of the Yangtze Block, South China, can be used to constrain the continental crustal growth and secular evolution of the region. LA-ICPMS zircon U-Pb dating of the Adebo quartz diorite pluton in the Ailaoshan tectonic zone on the southern margin of the Yangtze Block gives the Neoproterozoic age of 800 ± 7 Ma and ɛHf(t) values in the range of -1.03 to +3.75 with two-stage model age of 1.3-1.6 Ga. The pluton is characterized by relatively low SiO2 (60.97-64.41 wt. %) and total alkalis (K2O + Na2O, 7.35-9.14 wt. %) and high Al2O3 content (16.98-18.21 wt. %) with mg-number of 36-39. REE-normalized patterns show enrichment in LREE with (La/Yb)cn of 11.36 to 19.77 and Europium negative anomalies with Eu/Eu* = 0.61- 0.74. The samples are characterized by negative Nb-Ta ((Nb/La)n = 0.18-0.35) and P, Ti, Sr anomalies and high Y concentrations (33.79-41.04 ppm) and low Sr/Y ratios (5.65-10.16). Their isotopic composition are similar to those of the Neoproterozoic mafic igneous rocks in the Ailaoshan zone and the southwestern Yangtze Block, indicating that the quartz diorite was produced by partial melting of mafic lower crust. The diorite also shows the similar geochemical characteristics with adakitic rocks from thickened lower crust or amphibolite and eclogite experimental melts. In combination with their arc-related geochemical signatures and synchronous developed adakitic rocks in the region, the Adebo quartz diorite pluton might be produced in a subduction-related tectonic setting during Neoproterozoic crustal growth along the margins of Yangtze Block.PostprintPeer reviewe

How does interactive virtual reality enhance learning outcomes via emotional experiences? A structural equation modeling approach

IntroductionInterest in interactive virtual reality (IVR) is increasing due to its potential for embodied learning and group-led teaching. However, few studies have investigated the internal mechanism by which IVR technology features and learning experiences affect learning outcomes in terms of psychological and emotional value. Based on media technology models and the control value theory of achievement emotions (CVTAE), this study uses structural equation modeling (SEM) to investigate the correlations among the internal elements of IVR technology features, learning experiences, and learning outcomes. It also emphasizes the role played by emotional experience in this context.MethodsThe sample referenced by this study consisted of 480 college students (193 males) who were simultaneously engaged in guided inquiry and learning in an IVR-based COVID-19 pandemic science museum in groups of 10.ResultsThe findings suggest that presence and perceived enjoyment have a key mediating effect on the relationship between virtual reality (VR) features and perceived learning outcomes in an IVR-based learning simulation. In addition, the results indicate that presence is more strongly correlated with perceived learning effects, while enjoyment is more strongly correlated with learning satisfaction.DiscussionThese findings provide intellectual support and theoretical backing for VR-based instructional design and environmental development. Moreover, this study has practical value with regard to the future large-scale application of IVR to experiential teaching, group-led teaching, and the promotion of the digital transformation and intelligence upgrading in education

Large-strain self-weight consolidation of dredged sludge

Prediction for self-weight consolidation of dredged sludge is important for its reuse in civil engineering applications. In this work, considering the special nonlinear relationships of e – k and e – σ′ for dredged sludge, Gibson’s large strain consolidation equation was modified to simulate the self-weight consolidation process of dredged sludge. Using the finite difference method (FDM), the influences of four main parameters, including initial height, initial void ratio, void ratio at the liquid limit, and specific gravity of soil particles, on the consolidation process of dredged slurry were analyzed. For the aforementioned four parameters, the self-weight consolidation of dredged slurry is most sensitive to the variation of void ratio at the liquid limit, whereas its response to the change of specific gravity of soil particles is relatively subtle. Consolidation behaviors under other commonly used constitutive models were also calculated for comparison. It was found that the total settlement obtained by the present relation is larger than the results obtained using typical nonlinear constitutive relations, and the speed of consolidation is higher

Radioactive ^(198)Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

With Au nanocages as an example, we recently demonstrated that radioactive ^(198)Au could be incorporated into the crystal lattice of Au nanostructures for simple and reliable quantification of their in vivo biodistribution by measuring the γ radiation from ^(198)Au decay and for optical imaging by detecting the Cerenkov radiation. Here we extend the capability of this strategy to synthesize radioactive ^(198)Au nanostructures with a similar size but different shapes and then compare their biodistribution, tumor uptake, and intratumoral distribution using a murine EMT6 breast cancer model. Specifically, we investigated Au nanospheres, nanodisks, nanorods, and cubic nanocages. After PEGylation, an aqueous suspension of the radioactive Au nanostructures was injected into a tumor-bearing mouse intravenously, and their biodistribution was measured from the γ radiation while their tumor uptake was directly imaged using the Cerenkov radiation. Significantly higher tumor uptake was observed for the Au nanospheres and nanodisks relative to the Au nanorods and nanocages at 24 h postinjection. Furthermore, autoradiographic imaging was performed on thin slices of the tumor after excision to resolve the intratumoral distributions of the nanostructures. While both the Au nanospheres and nanodisks were only observed on the surfaces of the tumors, the Au nanorods and nanocages were distributed throughout the tumors

Radioactive ^(198)Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

With Au nanocages as an example, we recently demonstrated that radioactive ^(198)Au could be incorporated into the crystal lattice of Au nanostructures for simple and reliable quantification of their in vivo biodistribution by measuring the γ radiation from ^(198)Au decay and for optical imaging by detecting the Cerenkov radiation. Here we extend the capability of this strategy to synthesize radioactive ^(198)Au nanostructures with a similar size but different shapes and then compare their biodistribution, tumor uptake, and intratumoral distribution using a murine EMT6 breast cancer model. Specifically, we investigated Au nanospheres, nanodisks, nanorods, and cubic nanocages. After PEGylation, an aqueous suspension of the radioactive Au nanostructures was injected into a tumor-bearing mouse intravenously, and their biodistribution was measured from the γ radiation while their tumor uptake was directly imaged using the Cerenkov radiation. Significantly higher tumor uptake was observed for the Au nanospheres and nanodisks relative to the Au nanorods and nanocages at 24 h postinjection. Furthermore, autoradiographic imaging was performed on thin slices of the tumor after excision to resolve the intratumoral distributions of the nanostructures. While both the Au nanospheres and nanodisks were only observed on the surfaces of the tumors, the Au nanorods and nanocages were distributed throughout the tumors

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19

Paleoenvironment of Mesoproterozoic Gaoyuzhuang and Wumishan Formations, North China: New Insights from Geochemistry and Carbon and Oxygen Isotopes of Dolostones

The Mesoproterozoic Gaoyuzhuang and Wumishan Formations are major geothermal reservoirs in the Hebei Province, North China. Compared to the exploration of geothermal resources and heat-controlling structures, carbon and oxygen isotopic records of the two formations are limited. Here, we present integrated field, petrological, geochemical, carbon, and oxygen isotopic data of carbonate rocks from the Gaoyuzhuang and Wumishan Formations. The Wumishan Formation is characterized by higher CaO and MgO contents and lower SiO2 contents than the Gaoyuzhuang Formation, indicating that the source of the Wumishan Formation likely contains less terrigenous clastic materials. The two formations have low total rare earth element contents, similar to marine carbonate rocks. They show different Eu and Ce anomalies, Al/(Al + Fe + Mn) and Fe/Ti ratios, and (Co + Ni + Cu) contents. They generally show similar carbon isotopic compositions, whereas the carbonate rocks of the middle-upper Gaoyuzhuang Formation show lower δ18O values than the samples from the Wumishan and lower Gaoyuzhuang Formations. These data suggest that the two formations have experienced different transgressive–regressive cycles and that their sedimentary environments varied and were unstable in different sedimentary periods. The middle-upper Gaoyuzhuang Formation was likely affected by hydrothermal fluids, whereas the Wumishan Formation is composed of normal seawater deposits. Integrated evidence reveals that both of the Mesoproterozoic Gaoyuzhuang and Wumishan Formations were deposited in rift environments caused by the breakup of the Columbia/Nuna supercontinent