More AdS_3 correlators

We compute three-point functions for the $SL(2,\mathbb R)$-WZNW model. After reviewing the case of the two-point correlator, we compute spectral flow preserving and nonpreserving correlation functions in the space-time picture involving three vertex operators carrying an arbitrary amount of spectral flow. When only one or two insertions have nontrivial spectral flow numbers, the method we employ allows us to find expressions without any constraint on the spin values. Unlike these cases, the same procedure restrains the possible spin configurations when three vertices belong to nonzero spectral flow sectors. We perform several consistency checks on our results. In particular, we verify that they are in complete agreement with previously computed correlators involving states carrying a single unit of spectral flow.Comment: 22 pages. Minor changes. Some references adde

Un modello di percezione del colore, espresso da un problema di Cauchy in spazi di Banach

Scopo della tesi è studiare un modello di percezione cromatica, che descrive la propagazione dell'attività mediante un problema di Cauchy in spazi di Banach. Presentiamo dapprima il problema della stabilità delle soluzioni al problema di Cauchy tramite il metodo Lyapunov; prima in dimensione finita, e poi in spazi di Banach. Poi verifichiamo che l'equazione fondamentale di percezione cromatica ricade nel setting considerato e che il funzionale di Lyapunov associato verifica le ipotesi che assicurano la stabilità

Modification of blood pressure in postmenopausal women: role of hormone replacement therapy

The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial. Also, studies dealing with the administration of estrogens or hormone therapy (HT) have reported conflicting evidence. In general it seems that, despite some negative data on subgroups of later postmenopausal women obtained with oral estrogens, in particular conjugated equine estrogens (CEE), most of the data indicate neutral or beneficial effects of estrogen or HT administration on BP control of both normotensive and hypertensive women. Data obtained with ambulatory BP monitoring and with transdermal estrogens are more convincing and concordant in defining positive effect on BP control of both normotensive and hypertensive postmenopausal women. Overall progestin adjunct does not hamper the effect of estrogens. Among progestins, drospirenone, a spironolactone-derived molecule, appears to be the molecule with the best antihypertensive properties

The Controversial History of Hormone Replacement Therapy

The history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the first results of the Women's Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, HRT use dropped. The negative results of the study received wide publicity, creating panic among some users and new guidance for doctors on prescribing HRT. The clear message from the media was that HRT had more risks than benefits for all women. In the following years, a reanalysis of the WHI trial was performed, and new studies showed that the use of HRT in younger women or in early postmenopausal women had a beneficial effect on the cardiovascular system, reducing coronary disease and all-cause mortality. Notwithstanding this, the public opinion on HRT has not changed yet, leading to important negative consequences for women's health and quality of life

Spectral flow and conformal blocks in AdS3

In this article we investigate the structure of the four-point functions of the AdS3-WZNW model. We consider the integral expression for the unflowed four-point correlator involving at least one state in the discrete part of the spectrum derived by analytic continuation from the H+3 -WZNW model and we show that the conformal blocks can be obtained from those with an extremal-weight state by means of an intertwining operator. We adapt the procedure for dealing with correlators with a single unit of spectral flow charge and we get a factorized integral expression for the corresponding four-point function. We finally transform the formulas back to the space-time picture.Fil: Cagnacci, Yago Javier. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Iguri, Sergio Manuel. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentin

New needs for menopausal women during covid-19 pandemic. A physician-based investigation

It was evaluated whether the COVID-19 pandemic may have influenced the manifestation of menopausal symptoms. In a web interview, 143 physicians, experts on the menopause, were asked to rate their perceived prevalence of hot flush, sleep disorder, sexual disturbance, anxiety and depression as ‘rare’, ‘seldom’, ‘frequent’ and ‘very frequent’ in patients they managed prior to and during the COVID-19 pandemic. According to physicians, there was no major change in the prevalence of hot flush, sleep disorder and sexual disturbance but prevalence of anxiety (39-8% vs 75.5%; p < 0.0001) and depressive (35.6% vs 72.0%; p < 0.0001) symptoms increased during COVID-19 pandemic. COVID-19 pandemic has changed the composite picture of menopausal symptoms, challenging physicians to adjust their therapeutic approach to the new need. Approaches capable to treat vasomotor symptoms but also highly effective on mood disturbance should be preferred

Ospemifene in the management of vulvar and vaginal atrophy: Focus on the assessment of patient acceptability and ease of use

Endocrinological changes that occur with menopause lead to a chronic and progressive condition named vulvar and vaginal atrophy (VVA). This disease is characterized by symptoms such as dryness, dyspareunia, itching, burning, and dysuria. According to recent epidemiological studies, VVA has a high prevalence and can also occur in younger women prior to the menopause, negatively affecting quality of life, sexual function, intimacy and relationship with the partner. Accordingly, therapy should be effective, initiated early and continued for as long as possible. Up to recent years, available therapeutic options have included over-the-counter lubricants and moisturizers, vaginal oestrogens and systemic hormones. These products are not indicated for all women. Hormones are mostly contraindicated in women with a history of hormone-sensitive cancer and are frequently not accepted even by women without contraindications. Local therapies are frequently considered uncomfortable, difficult to apply, and messy. Indeed, these treatments have a high spontaneous discontinuation rate, mostly due to dissatisfaction, safety concern, side effects and difficulty in vaginal placement. Recently, ospemifene, a new non-hormonal systemic remedy, was approved by FDA (Food and Drug Administration) and EMA (European Medicines Agency) for the treatment of the two most bothersome symptoms of VVA: dryness and dyspareunia. Because ospemifene is a selective estrogen receptor modulator (SERM), it can be administered also in women with a history of breast cancer, and this makes it more acceptable by any woman. In addition, its route of administration minimizes those bothersome side effects intrinsic to the vaginal route of administration. Available data indicate that women using ospemifene have higher adherence to treatment, higher persistence and lower discontinuation rate. Satisfaction is higher than with other local therapies and overall health care cost is lower

L ∞ algebras and tensor hierarchies in Exceptional Field Theory and Gauged Supergravity

We show how the gauge and field structure of the tensor hierarchies in Double and E7(7) Exceptional Field Theory fits into L∞ algebras. Special attention is paid to redefinitions, the role of covariantly constrained fields and intertwiners. The results are connected to Gauged Supergravities through generalized Scherk-Schwarz reductions. We find that certain gauging-dependent parameters generate trivial gauge transformations, giving rise to novel symmetries for symmetries that are absent in their ungauged counterparts.Fil: Cagnacci, Yago Javier. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Codina, Tomas. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Marques, Diego. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentin

Memory drives the formation of animal home ranges: evidence from a reintroduction

Most animals live in home ranges, and memory is thought to be an important process in their formation. However, a general memory-based model for characterising and predicting home range emergence has been lacking. Here, we use a mechanistic movement model to: (1) quantify the role of memory in the movements of a large mammal reintroduced into a novel environment, and (2) predict observed patterns of home range emergence in this experimental setting. We show that an interplay between memory and resource preferences is the primary process influencing the movements of reintroduced roe deer (Capreolus capreolus). Our memory-based model fitted with empirical data successfully predicts the formation of home ranges, as well as emergent properties of movement and spatial revisitation observed in the reintroduced animals. These results provide a mechanistic framework for combining memory-based movements, resource preferences, and the formation of home ranges in nature