Lady Chatterly\u27s Lover: The Grove Press Publication of the Unexpurgated Text

This article details the excruciating process that author D. H. Lawrence went through to get his novel Lady Chatterly\u27s Lover published in the United States. It was censored multiple times, cited as being obscene and offensive, while Lawrence and his lawyers tried to build the case that the novel possessed literary merit. The research used to write this article was based on findings in the Syracuse Univeristy Special Collections

Speaking to the Head and the Heart: Prioritizing Empathetic Communication in the Post-COVID Workplace

As of August 2022, COVID-19 continues to affect our daily lives in physical, psychological, and financial ways. Many vulnerable individuals are struggling to adapt to returning to work and as a result, employee morale is at risk. In times of crises, empathy is needed in the workplace to support one another, but many leaders and employees may not have a firm grasp of the concept. This article seeks to define empathetic communication and explore the need for prioritizing empathy amid the current post-COVID-19 workplace. Through a literature review of empathy, psychological safety in the workplace, and crisis leadership, the author explains how the development of empathetic communication must be intentional to achieve sustainable change and lead to long-term organizational success. Practical recommendations are provided on how organizations should define empathetic communication, provide training for leaders and employees, and incorporate empathetic communication as a standard of responsibility for every employee to be assessed on a regular basis

Electronically tuned optical filters

Electro-optical effect of light modifying type for electronically controlling colo

The Lunar Atmosphere and Dust Environment Explorer (LADEE) Mission

The Lunar Atmosphere and Dust Environment Explorer (LADEE) is a Lunar science orbiter mission currently under development to address the goals of the National Research Council decadal surveys and the recent "Scientific Context for Exploration of the Moon" (SCEM) [1] report to study the pristine state of the lunar atmosphere and dust environment prior to significant human activities. LADEE will determine the composition of the lunar atmosphere and investigate the processes that control its distribution and variability, including sources, sinks, and surface interactions. LADEE will also determine whether dust is present in the lunar exosphere, and reveal the processes that contribute to its sources and variability. These investigations are relevant to our understanding of surface boundary exospheres and dust processes throughout the solar system, address questions regarding the origin and evolution of lunar volatiles, and have potential implications for future exploration activities. LADEE employs a high heritage science instrument payload including a neutral mass spectrometer, ultraviolet spectrometer, and dust sensor. In addition to the science payloads, LADEE will fly a laser communications system technology demonstration that could provide a building block for future space communications architectures. LADEE is an important component in NASA's portfolio of near-term lunar missions, addressing objectives that are currently not covered by other U.S. or international efforts, and whose observations must be conducted before large-scale human or robotic activities irrevocably perturb the tenuous and fragile lunar atmosphere. LADEE will also demonstrate the effectiveness of a low-cost, rapid-development program utilizing a modular bus design launched on the new Minotaur V launch vehicle. Once proven, this capability could enable future lunar missions in a highly cost constrained environment. This paper describes the LADEE objectives, mission design, and technical approach

Optimal Duration for Continuation of Statin Therapy in Bacteremic Patients

Background: Evidence suggests statins may improve survival in patients with bloodstream infections. However, there is no consensus on optimal timing and duration of exposure. Objectives: To quantify statin therapy duration associated with decreased mortality in bacteremic statin users. Methods: We conducted a case-control study using OptumClinformatics™ with matched Premier hospital data (1 October 2009–31 March 2013). Cases who died during the hospitalization were matched 1:1 to survivors on disease risk scores (DRSs). Post-admission statin therapy duration was evaluated in patients with at least 90 days of pre-admission continuous statin use. Classification and regression tree (CART) analysis was conducted to identify the optimal duration of statin continuation which provided the lowest inpatient mortality. Logistic regression was used to calculate the odds of mortality. Results: We included 58 DRS matched pairs of cases and controls: 47 patients (41%) continued statin therapy during the hospital admission, 15 (32%) cases and 32 (68%) controls. The CART analysis partitioned the continuation of statin therapy at ⩾2 days, representing lower mortality for patients who continued statins for 2 days or more and higher mortality for patients who did not continue or remained on statins for only 1 day. Inpatient mortality was 76% lower among those with at least 2 days of continued statin use (odds ratio 0.24, 95% confidence interval 0.11–0.55)

Sophomores Reign On!: A Sophomore Student Success Model for Old Dominion University

The Division of Student Engagement and Enrollment Services at Old Dominion University (ODU) submitted a Request for Assistance to examine the challenges sophomore students face that can lead to attrition. A doctoral research team conducted an exploratory, sequential, mixed-methods study consisting of a literature review, focus groups and interviews with current ODU juniors and seniors, surveys of current ODU sophomores, staff, and faculty, and interviews with benchmark institutions that have successful sophomore student programming at their schools. The team explained the commonly found needs and barriers that sophomore students face, and specifically examined the expressed sophomore student challenges as revealed by ODU students, staff, and faculty. Findings indicated that there is a lack of transitional support, sophomore student development training, and a defined sophomore student experience at ODU. In response to these findings, the team created a sophomore student success model that recommends developing a sophomore orientation program, training staff and faculty on sophomore needs and development, creating a streamlined mentoring program, evaluating current academic advising models, and designing a Sophomore Year Experience (SYE)

The genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors approximately 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi

Intelligent subsystem interface for modular hardware system

A single chip application specific integrated circuit (ASIC) which provides a flexible, modular interface between a subsystem and a standard system bus. The ASIC includes a microcontroller/microprocessor, a serial interface for connection to the bus, and a variety of communications interface devices available for coupling to the subsystem. A three-bus architecture, utilizing arbitration, provides connectivity within the ASIC and between the ASIC and the subsystem. The communication interface devices include UART (serial), parallel, analog, and external device interface utilizing bus connections paired with device select signals. A low power (sleep) mode is provided as is a processor disable option

Higher Daptomycin Dose Associated with Improved Survival in Methicillin-Resistant Staphylococcus aureus Bacteremia

Study Objective: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and case series studies. This study evaluated the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia. Design: Retrospective national cohort study. Setting: Veterans Affairs medical centers. Patients: A total of 371 adults with MRSA bacteremia who were admitted between 2002 and 2015 and treated initially with vancomycin within 24 hours of initial culture collection and then switched to daptomycin therapy within 7 days; 138 patients (37.2%) received daptomycin doses higher than the daptomycin label dose (7 mg/kg or greater), and 233 (62.8%) received the daptomycin label dose (6 mg/kg). Measurements and Main Results: Clinical outcomes were compared among those who received the daptomycin label dose and those who received the higher dose using propensity score–matched Cox proportional hazards regression models. To identify dose partitioning associated with optimal survival, classification and regression tree (CART) analysis was used among patients, controlling for confounding with a 30-day mortality disease risk score. Propensity score–matched 30-day mortality was 8.6% (6/70 patients) among the higher dose group versus 18.6% (13/70 patients) among the label dose group (hazard ratio 0.31, 95% confidence interval 0.10–0.94). No significant differences were observed in inpatient mortality, length of stay, 30-day readmission, or 30-day S. aureus reinfection between groups. CART analysis resulted in doses of 7 mg/kg or greater providing benefit only among patients with higher (more than 51%) predicted probabilities of 30-day mortality (p\u3c0.001). Conclusion: To our knowledge, this is the first comparative effectiveness study of daptomycin doses in patients with MRSA bacteremia. Survival benefits were observed with doses higher than the daptomycin label dose (7 mg/kg or greater) for the treatment of MRSA bacteremia. These data suggest that higher doses than the daptomycin label dose may be preferred over the label dose for improving clinical outcomes in patients with MRSA bacteremia