Preliminary results of a randomized E.O.R.T.C. study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx

The purpose of this randomized trial was to verify some experimental and clinical data suggesting a possible potentiating effect of bleomycin when used concomitantly with radiotherapy. Out of 220 patients with a biopsy proven epidermoid carcinoma of the oropharynx, 186 evaluable cases are reported here. One group of 87 patients was treated with radiotherapy alone (Cobalt 60 ∼ 6400 rad ∼ 7-8.5 weeks), the other group of 99 patients received radiotherapy combined with bleomycin, the latter administered at the dose of 15 mg i.m. twice a week for 5 weeks (total dose: 150 mg). Analysis of the treatment groups showed their comparability with regard to the most important prognostic factors (TNM, sites of primary, sex, age .). Complication rates of mucositis and epidermitis were significantly increased (71%) in the radiotherapy + bleomycin group and were considered responsible of frequent denutrition and weight loss in this group. Such side effects necessitated a delay of radiotherapy in 22% of patients and definitive interruption in 5% in the combined treatment group whereas in the radiotherapy alone group no interruption of treatment was recorded and only 5 treatments (6%) were postponed. Considering tumor regressions measured 6 weeks after completion of radiation therapy, total regression rates were not significantly different in both groups as far as primary tumor (67.9-67%) or neck nodes (49-62%) are concerned. Survival curves obtained by the actuarial method showed the same 50% survival in both groups at 15 months of follow-up. © 1977.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Carnets. Tome IV

De 1906 à 1947, Marcel Cachin nota jour après jour ses impressions, ses analyses, et surtout, avec une étonnante méticulosité, le détail de ses conversations, de ses rencontres, de ses observations. Membre de la direction du Parti socialiste entre 1907 et 1920, rédacteur de l’Humanité en 1912, avant d’en être le directeur de 1918 à sa mort, quarante ans plus tard, membre de la direction du Parti communiste depuis sa création, Marcel Cachin occupa les plus hautes responsabilités dans le mouvement socialiste, puis dans le mouvement communiste. De Jaurès à Lénine, de Guesde à Trotsky, de Thorez à Clara Zetkin, de Duclos à Boukharine, mais aussi de Lefranc à Bourgeois, ou de Charles à Antoine, ils sont des milliers à défiler, du militant de base aux dirigeants français ou russes, allemands ou finlandais. Avec cet ensemble de près de 3 000 pages, en 4 volumes, nous disposons d’une source d’une importance cruciale pour comprendre la France politique et sociale de la première moitié du XXe siècle. Au moment du Front populaire et à la Libération convergent la stratégie du PCF et l’idée que Cachin se fait naturellement de l’action politique. Les responsabilités qu’il conserve au sein du parti français et celles qu’il prend dans les instances internationales - au sein du Komintern ou dans la direction du Rassemblement universel pour la paix (RUP) - font du quatrième tome qui couvre les années 1935-1947 un document de toute première importance. L’accès aux archives de Moscou et l’exploitation du fonds privé Cachin ont permis de nourrir les notes et les préfaces des découvertes les plus récentes de la recherche historique

Low-dose dual-isotope procedure planed for myocardial perfusion CZT-SPECT and assessed through a head-to-head comparison with a conventional single-isotope protocol

International audiencePurpose of the report: This study aimed at assessing an original low-dose dual-isotope procedure in which the abnormal stress Tc-99m Sestamibi SPECT is followed by rest Tl-201 SPECT, along with a head-to-head comparison with a single-isotope procedure.Methods and results: One hundred two patients, referred for a low-dose stress-SPECT with Sestamibi (123 ± 20 MBq) on a CZT camera and for whom a rest Sestamibi SPECT was warranted, had an additional Tl-201 rest-SPECT (52 ± 5 MBq) between stress and rest Sestamibi SPECT recordings. Tl-201 images were processed for spill-over and scatter corrections, and uptake differences with stress Sestamibi SPECT were analyzed: (1) for rest acquisitions from Tl-201 (dual-isotope procedure) and from Sestamibi (single-isotope procedure) and (2) in segments for which a diagnosis of ischemia, infarct, or normal perfusion was achieved. Mean effective dose was 8.3 mSv for dual-isotope but would decrease to 5.7 mSv for an expected rate of 37% of patients for whom rest-SPECT is not warranted. After a further background correction of Tl-201 images, the rest-stress difference in myocardial uptake was equivalent between dual- and single-procedures for identifying ischemic segments (respective areas-under-curves: 0.83 ± 0.03 and 0.81 ± 0.03).Conclusion: This original dual-isotope procedure provides acceptable radiation doses and consistent results, as compared with conventional single-isotope

Functional Alterations Due to COVID-19 Lung Lesions—Lessons From a Multicenter V/Q Scan-Based Registry

International audienc

Contributors

1.1 18.10.2001 Revised Outline of document 1.2 10.02.2002 Modifications to put text in sync with D2 1.3 20.04.2002 Modification on Section related to THOR 2.0 10.05.2002 Major revision on the sections related to false alarm handling 2.1 04.06.2002 Major revision on the section related to RIDAX 2.2 18.06.2002 Major revision of the last chapter 3.0 23.06.2002 Minor revision of the whole text 4.0 09.07.2002 Added middleware example, numerous corrections 4.1 17.07.2002 Numerous corrections 4.2 18.07.2002 Improved references 4.3 09.08.2002 Minor correction

Dual time point [18F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues

International audienceFor differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([18F]FDG) dual time point PET could be helpful. Albeit [18F]FLT is more specific for tumors than [18F]FDG; we explored the role of dual time point [18F]FLT-PET for discriminating benign from malignant tissues

Stimulated thyroglobulin and Thyroglobulin Reduction Index Predict Excellent Response in Differentiated Thyroid Cancers

International audienceDespite its good prognosis, differentiated thyroid cancer (DTC) is characterized by a high risk of disease persistence and/or recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to personalize the schedule of active surveillance