Studio dell’insediamento protostorico in un’area della Sardegna centro-occidentale tramite strumenti GIS ed analisi multivariate

The authors analyze, as a sample-area, the region that includes the municipality of Mogoro, in central-western Sardinia, with the objective to reconstruct, through the study of the settlements and their relationships, some economic and social aspects of the human groups of nuragic culture that inhabited this area between the 18th and the 8th century BC. The territory is located at the foot of Monte Arci, along the Mogoro river that runs through the southern part of the plain of the Campidano of Oristano. The area has been intensively investigated from the half of the past century; an in-depth stratigraphic investigation was carried out since 1994 near the nuragic site of Cuccurada, the main center of an articulated territorial system including a rich network of monuments related to the nuragic civilization. The results are illustrated through various research methods: GIS, with the application of spatial analysis tools, and multivariate analysis (cluster and principal components analysis) that allowed to set out new hypotheses on occupation and populating dynamics and to identify among pre-historical monuments one or more homogeneous and distinguishable groups, resulting from a database in which geomorphological characteristics are recorded. A hierarchical organization and a specific criterion for exploiting and monitoring the landscape have been developed, in which settlement choices depend on functionality criteria, having nuraghi and villages a key role on the strategic control of the territor

The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance

Taste sensitivity to PROP varies greatly among individuals and is associated with polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform papilla density on the anterior tongue surface. Recently we showed that the PROP non-taster phenotype is strongly associated with the G variant of polymorphism rs2274333 (A/G) of the gene that controls the salivary trophic factor, gustin. The aims of this study were 1) to investigate the role of gustin gene polymorphism rs2274333 (A/G), in PROP sensitivity and fungiform papilla density and morphology, and 2) to investigate the effect of this gustin gene polymorphism on cell proliferation and metabolic activity. Sixty-four subjects were genotyped for both genes by PCR techniques, their PROP sensitivity was assessed by scaling and threshold methods, and their fungiform papilla density, diameter and morphology were determined. In vitro experiments examined cell proliferation and metabolic activity, following treatment with saliva of individuals with and without the gustin gene mutation, and with isolated protein, in the two iso-forms. Gustin and TAS2R38 genotypes were associated with PROP threshold (p=0.0001 and p=0.0042), but bitterness intensity was mostly determined by TAS2R38 genotypes (p<0.000001). Fungiform papillae densities were associated with both genotypes (p<0.014) (with a stronger effect for gustin; p=0.0006), but papilla morphology was a function of gustin alone (p<0.0012). Treatment of isolated cells with saliva from individuals with the AA form of gustin or direct application of the active iso-form of gustin protein increased cell proliferation and metabolic activity (p<0.0135). These novel findings suggest that the rs2274333 polymorphism of the gustin gene affects PROP sensitivity by acting on fungiform papilla development and maintenance, and could provide the first mechanistic explanation for why PROP super-tasters are more responsive to a broad range of oral stimul

Grid services for the MAGIC experiment

Exploring signals from the outer space has become an observational science under fast expansion. On the basis of its advanced technology the MAGIC telescope is the natural building block for the first large scale ground based high energy gamma-ray observatory. The low energy threshold for gamma-rays together with different background sources leads to a considerable amount of data. The analysis will be done in different institutes spread over Europe. Therefore MAGIC offers the opportunity to use the Grid technology to setup a distributed computational and data intensive analysis system with the nowadays available technology. Benefits of Grid computing for the MAGIC telescope are presented.Comment: 5 pages, 1 figures, to be published in the Proceedings of the 6th International Symposium ''Frontiers of Fundamental and Computational Physics'' (FFP6), Udine (Italy), Sep. 26-29, 200

Tiger Beetles (Coleoptera: Carabidae: Cicindelinae) of Compostela Valley Province, Mindanao Island, Philippines

The first faunistic record of tiger beetles (Coleoptera: Carabidae: Cicindelinae) in Compostela Valley Province, Mindanao with notes on their habitat is presented. Opportunistic sampling, standard light trapping and photo documentation were conducted in selected areas from January to April 2013 and in September 2015. One hundred four tiger beetles belonging to twelve species and seven genera were recorded. An astonishing (100%) endemicity was observed identified to subspecies level. Thopeutica and Calomera species, specifically Thopeutica anichtchenkoi Wiesner, 2015 and Calomera mindaoensis Cassola, 2000 were observed to be abundant in the samples mostly found in the mountainous and forested open riparian ecosystem of Cagan, New Bataan. Cylindera (Ifasina) discreta elaphroides (Dokhtouroff 1882) was the most common species and was found in different habitat types, but the majority of the species showed a narrow and specialized habitat preference. Protection and conservation of remaining forest areas in Cagan is especially important in preserving endemic species

The Mediational Role of Desire for Cultural Tightness on Concern With COVID-19 and Perceived Self-Control

When ecological threats are more severe or prevalent, societies are more likely to tighten their social norms and punishments. Moreover, when people follow clear and tight rules, they are more prone to regulate their behavior (i.e., self-control) in order to avoid punishment. Therefore, we examined the mediating role of people’s endorsement of cultural tightness (i.e., support and desire) on the relationship between concern with COVID-19 threat and personal self-control. Our hypothesis was tested through a mediation model in two studies with a sample of (N=315, 77.1% females, Mage=23.71) university students (Study 1) and with a heterogeneous sample of (N=239, 65.7% females, Mage=36.55) participants (Study 2). Empirical support for the proposed model was found in both studies. Implications of this research will be discussed. The main implication is related to the possibility that people’s desire for strong norms to cope with the COVID-19 threat could promote greater self-regulated preventive behavior in order to protect their health

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

Objectives: Although the hepatomitogenic activity of triiodothyronine (T3) is well established, the wide range of harmful effects exerted by this hormone precludes its use in liver regenerative therapy. Selective agonists of the beta isoform of thyroid hormone receptor (TRβ) do not exhibit T3-induced cardiotoxicity and show a good safety profile in patients with NASH. The aim of this study was to investigate whether two novel TRβ agonists, the prodrug TG68 and the active compound IS25 could stimulate hepatocyte proliferation without T3/TRα-dependent side effects. Methods: Rats were treated with three different doses (12.5, 25 and 50&nbsp;μg/100&nbsp;g body weight) for one week. Hepatocyte proliferation, liver injury and serum biochemical&nbsp;parameters were measured by immunohistochemistry, qRT-PCR and Western blot. Results: Both drugs increased hepatocyte proliferation as assessed by bromodeoxyuridine incorporation (from 14% to 28% vs 5% of controls) and mitotic activity. Enhanced proliferation occurred in the absence of significant signs of liver injury as shown by lack of increased serum transaminase levels or of apoptosis. No cardiac or renal hypertrophy typically associated with treatment with T3 was observed. Importantly, no proliferation of pancreatic acinar cells, such as that seen after administration of T3 or the TRβ agonist GC1 was detected following either TG68 or IS25, demonstrating the hepato-specificity of these novel TRβ agonists. Conclusions: The present study shows that TG68 and IS25 induce massive hepatocyte proliferation without overt toxicity. Hence, these agents may have a significant clinical application for regenerative therapies in liver transplantation or other surgical settings

Spectral Analysis of the LMXB XTE J1810-189 with NICER Data

XTE J1810-189 is a Low-Mass X-ray Binary transient system hosting a neutron star, which underwent a three-month-long outburst in 2020. In order to study its spectral evolution during this outburst, we analysed all the available observations performed by NICER, in the 1-10 keV energy band. Firstly, we fitted the spectra with a thermal Comptonisation model. Our analysis revealed the lack of a significant direct emission from a black-body-like component, therefore we calculated the optical depth of the Comptonising region, deriving an upper limit of 4.5, which suggests the presence of a moderately thick corona. We also attempted to fit the spectrum with an alternative model, i.e. a cold Comptonised emission from a disc and a direct thermal component from the neutron star, finding a similarly good fit. The source did not enter a full high luminosity/soft state throughout the outburst, with a photon index ranging from 1.7 to 2.2, and an average unabsorbed flux in the 1-10 keV band of 3.6x10^(-10) erg cm^(-2) s^(-1). We searched for the presence of Fe K-shell emission lines in the range 6.4-7 keV, significantly detecting a broad component only in a couple of observations. Finally, we conducted a time-resolved spectral analysis of the detected type-I X-ray burst, observed during the outburst, finding no evidence of a photospheric radius expansion. The type-I burst duration suggests a mix of H/He fuel.Comment: 11 pages, 8 figures, accepted for publication on MNRA