55 research outputs found
Controlling electric and magnetic Purcell effects in phosphorene via strain engineering
We investigate the spontaneous emission lifetime of a quantum emitter near a
substrate coated with phosphorene under the influence of uniaxial strain. We
consider both electric dipole and magnetic dipole-mediated spontaneous
transitions from the excited to the ground state. The modeling of phosphorene
is performed by employing a tight-binding model that goes beyond the usual
low-energy description. We demonstrate that both electric and magnetic decay
rates can be strongly tuned by the application of uniform strain, ranging from
a near-total suppression of the Purcell effect to a remarkable enhancement of
more than 1300% due to the high flexibility associated with the puckered
lattice structure of phosphorene. We also unveil the use of strain as a
mechanism to tailor the most probable decay pathways of the emitted quanta. Our
results show that uniaxially strained phosphorene is an efficient and versatile
material platform for the active control of light-matter interactions thanks to
its extraordinary optomechanical properties
Clone Embrapa 51: uma alternativa para resistênica à resinose-do-cajueiro.
São apresentados os resultados de cinco anos de monitoramento de clones comerciais de cajueiro, quanto à reação de resinose.bitstream/CNPAT/10571/1/cot_130.pd
Transmissão de Lasiodiplodia theobromae, agente da resinose, em propágulos de cajueiro.
bitstream/CNPAT-2010/11983/1/Bd-034.pd
Ocorrência endofítica de Lasiodiplodia theobromae em tecidos de cajueiro e sua transmissão por propágulos.
Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection
Chronic use of statins may have anti-inflammatory action, promoting immunomodulation and survival in patients with sepsis. This study aimed to analyze the effects of pretreatment with simvastatin in lethal sepsis induced by cecal ligation and puncture (CLP). Male Swiss mice received prophylactic treatment with simvastatin or pyrogen-free water orally in a single daily dose for 30 days. After this period, the CLP was performed. Naïve and Sham groups were performed as non-infected controls. Animal survival was monitored for 60 h after the CLP. Half of mice were euthanized after 12 h to analyze colony-forming units (CFUs); hematological parameters; production of IL-10, IL-12, IL-6, TNF-α, IFN-γ, and MCP-1; cell counts on peritoneum, bronchoalveolar lavage (BAL), bone marrow, spleen, and mesenteric lymph node; immunephenotyping of T cells and antigen presenting cells and production of hydrogen peroxide (H2O2). Simvastatin induced an increase in survival and a decrease in the CFU count on peritoneum and on BAL cells number, especially lymphocytes. There was an increase in the platelets and lymphocytes number in the Simvastatin group when compared to the CLP group. Simvastatin induced a greater activation and proliferation of CD4+ T cells, as well as an increase in IL-6 and MCP-1 production, in chemotaxis to the peritoneum and in H2O2 secretion at this site. These data suggest that simvastatin has an impact on the survival of animals, as well as immunomodulatory effects in sepsis induced by CLP in mice
Impact of Continuous Axenic Cultivation in Leishmania infantum Virulence
Experimental infections with visceral Leishmania spp. are frequently performed referring to stationary parasite cultures that are comprised of a mixture of metacyclic and non-metacyclic parasites often with little regard to time of culture and metacyclic purification. This may lead to misleading or irreproducible experimental data. It is known that the maintenance of Leishmania spp. in vitro results in a progressive loss of virulence that can be reverted by passage in a mammalian host. In the present study, we aimed to characterize the loss of virulence in culture comparing the in vitro and in vivo infection and immunological profile of L. infantum stationary promastigotes submitted to successive periods of in vitro cultivation. To evaluate the effect of axenic in vitro culture in parasite virulence, we submitted L. infantum promastigotes to 4, 21 or 31 successive in vitro passages. Our results demonstrated a rapid and significant loss of parasite virulence when parasites are sustained in axenic culture. Strikingly, the parasite capacity to modulate macrophage activation decreased significantly with the augmentation of the number of in vitro passages. We validated these in vitro observations using an experimental murine model of infection. A significant correlation was found between higher parasite burdens and lower number of in vitro passages in infected Balb/c mice. Furthermore, we have demonstrated that the virulence deficit caused by successive in vitro passages results from an inadequate capacity to differentiate into amastigote forms. In conclusion, our data demonstrated that the use of parasites with distinct periods of axenic in vitro culture induce distinct infection rates and immunological responses and correlated this phenotype with a rapid loss of promastigote differentiation capacity. These results highlight the need for a standard operating protocol (SOP) when studying Leishmania species
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