17,154 research outputs found
Slow cooling and efficient extraction of C-exciton hot carriers in MoS2 monolayer
In emerging optoelectronic applications, such as water photolysis, exciton fission and novel photovoltaics involving low-dimensional nanomaterials, hot-carrier relaxation and extraction mechanisms play an indispensable and intriguing role in their photo-electron conversion processes. Two-dimensional transition metal dichalcogenides have attracted much attention in above fields recently; however, insight into the relaxation mechanism of hot electron-hole pairs in the band nesting region denoted as C-excitons, remains elusive. Using MoS2 monolayers as a model two-dimensional transition metal dichalcogenide system, here we report a slower hot-carrier cooling for C-excitons, in comparison with band-edge excitons. We deduce that this effect arises from the favourable band alignment and transient excited-state Coulomb environment, rather than solely on quantum confinement in two-dimension systems. We identify the screening-sensitive bandgap renormalization for MoS2 monolayer/graphene heterostructures, and confirm the initial hot-carrier extraction for the C-exciton state with an unprecedented efficiency of 80%, accompanied by a twofold reduction in the exciton binding energy
Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse Model by Downregulation of Cell Signaling Pathway Leading to Invasion and Angiogenesis
Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model.Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model. Xenogen in vivo imaging system was used to monitor tumor growth and metastasis. The effect of withaferin A on tumor volume, invasive growth pattern, expression of Pyk2, upregulation of BAX/P53, apoptotic signaling and ROCK/IP10/VEGF pathway along with cytoskeletal protein actin projection formation was studied. Tumor/non-tumor margin was examined under electron microscopy. In addition, the direct effect of withaferin A on liver cancer cells and endothelial cells was further investigated.Results: A significant inhibition of tumor growth and lower incidence of lung metastasis was observed after withaferin A treatment. Withaferin A treatment led to a decrease in the incidence of intrahepatic metastasis from 90 (9 of 10) to 10 % (1 of 10, p = 0.041). There was decrease in macrophage infiltration in the liver tumors and vessels. Western blot analysis revealed inhibition of expression of Pyk2, ROCK1 protein and VEGF. Electron microscopy showed tumor vascular endothelial cell damage and significant necrosis of tumor tissues. It also suppressed formation of cytoskeletal protein actin projection involved in cell migration.Conclusion: Withaferin A inhibits liver tumor invasion and angiogenesis by downregulation of cell signalling pathway leading to invasion and angiogenesis. Therefore, withaferin A is a promising candidate for the treatment of liver tumor invasion and angiogenesis.Keywords: Withaferin A, Macrophage, Lung metastasis, Angiogenesis, Vascular endothelial growth factor, Rho kinase, Withania somnifer
Fault estimation for a class of nonlinear dynamical systems
In this paper, model based fault estimation for a class of nonlinear dynamical systems is investigated. The state of the system is assumed unavailable, and a nonlinear observer is used to estimate the state. In the observer, neurofuzzy network is used as the approximator to estimate faults. The network is trained on-line and the convergence of the proposed learning algorithm is established. Abrupt fault and incipient fault are analyzed in the paper and they can be estimated accurately using neurofuzzy network with the proposed learning algorithm.published_or_final_versio
Online fault detection and isolation of nonlinear systems
This paper describes an online fault detection scheme for a class of nonlinear dynamic systems with modelling uncertainty and inaccessible states. Only the inputs and outputs of the system can be measured. The faults are assumed to be functions of the state, instead of the output and the input of the system. A nonlinear online approximator using dynamic recurrent neural network is utilised to monitor the faults in the system. The construction and the learning algorithm of the online approximator are presented. The stability, robustness and sensitivity of the fault detection scheme under certain assumptions are analysed. An example demonstrates the efficiency of the proposed fault detection scheme.published_or_final_versio
Modelling of nonlinear stochastic dynamical systems using neurofuzzy networks
Though nonlinear stochastic dynamical system can be approximated by feedforward neural networks, the dimension of the input space of the network may be too large, making it to be of little practical importance. The Nonlinear Autoregressive Moving Average model with eXogenous input (NARMAX) is shown to be able to represent nonlinear stochastic dynamical system under certain conditions. As the dimension of the input space is finite, it can be readily applied in practical application. It is well known that the training of recurrent networks using gradient method has a slow convergence rate. In this paper, a fast training algorithm based on the Newton-Raphson method for recurrent neurofuzzy network with NARMAX structure is presented. The convergence and the uniqueness of the proposed training algorithm are established. A simulation example involving a nonlinear dynamical system corrupted with the correlated noise and a sinusoidal disturbance is used to illustrate the performance of the proposed training algorithm.published_or_final_versio
Cyber Inference System for Substation Anomalies Against Alter-and-Hide Attacks
Alarms reported to energy control centers are an indication of abnormal events caused by either weather interruptions, system errors, or possibly intentional anomalies. Although these initiating events are random, e.g., faults on transmission lines struck by lightning, the existence of electronically altered measurements may implicate the process to identify root causes of abnormal events. This paper is concerned with alter-andhide (AaH) attacks by tampering the actual measurements to normal states with the background of disruptive switching actions that hide the true values of local events from operators at the control center. A cyber inference system (CyIS) framework is proposed to synthesize all sequential, missing, or altered alarms of related substations against AaH attacks. The stochastic nature of such attack events is modeled with probabilities as an integer programming problem with multiple scenarios. The proposed method is utilized to verify alarm scenarios for a conclusion of the potential AaH attacks on the substations.postprin
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Evolution of superconductivity in K2-xFe4+ySe5: Spectroscopic studies of X-ray absorption and emission.
This study investigates the evolution of superconductivity in K2-xFe4+ySe5 using temperature-dependent X-ray absorption and resonant inelastic X-ray scattering techniques. Magnetization measurements show that polycrystalline superconducting (SC) K1.9Fe4.2Se5 has a critical temperature (T c) of ∼31 K with a varying superconducting volume fraction, which strongly depends on its synthesis temperature. An increase in Fe-structural/vacancy disorder in SC samples with more Fe atoms occupying vacant 4d sites is found to be closely related to the decrease in the spin magnetic moment of Fe. Moreover, the nearest-neighbor Fe-Se bond length in SC samples exceeds that in the non-SC (NS) sample, K2Fe4Se5, which indicates a weaker hybridization between the Fe 3d and Se 4p states in SC samples. These results clearly demonstrate the correlations among the local electronic and atomic structures and the magnetic properties of K2-xFe4+ySe5 superconductors, providing deeper insight into the electron pairing mechanisms of superconductivity
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Experimental observation of chiral phonons in monolayer WSe2
Chirality characterizes an object that is not identical to its mirror image. In condensed matter physics, Fermions have been demonstrated to obtain chirality through structural and time-reversal symmetry breaking. These systems display unconventional electronic transport phenomena such as the quantum Hall effect and Weyl semimetals. However, for bosonic collective excitations in atomic lattices, chirality was only theoretically predicted and has never been observed. We experimentally show that phonons can exhibit intrinsic chirality in monolayer tungsten diselenide, whose lattice breaks the inversion symmetry and enables inequivalent electronic K and -K valley states. The time-reversal symmetry is also broken when we selectively excite the valley polarized holes by circularly polarized light. Brillouin-zone-boundary phonons are then optically created by the indirect infrared absorption through the hole-phonon interactions. The unidirectional intervalley transfer of holes ensures that only the phonon modes in one valley are excited. We found that such photons are chiral through the transient infrared circular dichroism, which proves the valley phonons responsible to the indirect absorption has non-zero pseudo-angular momentum. From the spectrum we further deduce the energy transferred to the phonons that agrees with both the first principle calculation and the double-resonance Raman spectroscopy. The chiral phonons have significant implications for electron-phonon coupling in solids, lattice-driven topological states, and energy efficient information processing
Gauge invariant definition of the jet quenching parameter
In the framework of Soft-Collinear Effective Theory, the jet quenching
parameter, , has been evaluated by adding the effect of Glauber gluon
interactions to the propagation of a highly-energetic collinear parton in a
medium. The result, which holds in covariant gauges, has been expressed in
terms of the expectation value of two Wilson lines stretching along the
direction of the four-momentum of the parton. In this paper, we show how that
expression can be generalized to an arbitrary gauge by the addition of
transverse Wilson lines. The transverse Wilson lines are explicitly computed by
resumming interactions of the parton with Glauber gluons that appear only in
non-covariant gauges. As an application of our result, we discuss the
contribution to coming from transverse momenta of order in a
medium that is a weakly-coupled quark-gluon plasma.Comment: 31 pages, 7 figures; journal versio
CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain
The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and CXCR4 are expressed in various kinds of nociceptive structures, and CXCL12/CXCR4 axis possesses pronociceptive property. Recent studies have demonstrated its critical roles in the development and maintenance of pathological pain, and both neuronal and glial mechanisms are involved in this CXCL12/CXCR4 axis-mediated pain processing. In this review, we summarize the recent development of the roles and mechanisms of CXCL12/CXCR4 axis in the pathogenesis of chronic pain by sciatic nerve injury, human immunodeficiency virus-associated sensory neuropathy, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia. The potential targeting of CXCL12/CXCR4 axis as an effective and broad-spectrum pharmacological approach for chronic pain therapy was also discussed.published_or_final_versio
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