872 research outputs found
Erratum to: Phosphotriesterase-related protein sensed albuminuria and conferred renal tubular cell activation in membranous nephropathy
Classical and Quantum Equations of Motion for a BTZ Black String in AdS Space
We investigate gravitational collapse of a -dimensional BTZ black
string in AdS space in the context of both classical and quantum mechanics.
This is done by first deriving the conserved mass per unit length of the
cylindrically symmetric domain wall, which is taken as the classical
Hamiltonian of the black string. In the quantum mechanical context, we take
primary interest in the behavior of the collapse near the horizon and near the
origin (classical singularity) from the point of view of an infalling observer.
In the absence of radiation, quantum effects near the horizon do not change the
classical conclusions for an infalling observer, meaning that the horizon is
not an obstacle for him/her. The most interesting quantum mechanical effect
comes in when investigating near the origin. First, quantum effects are able to
remove the classical singularity at the origin, since the wave function is
non-singular at the origin. Second, the Schr\"odinger equation describing the
behavior near the origin displays non-local effects, which depend on the energy
density of the domain wall. This is manifest in that derivatives of the
wavefunction at one point are related to the value of the wavefunction at some
other distant point.Comment: 9 pages, 1 figure. Minor Clarification and corrections. Accepted for
Publication in JHE
The protective effects of catechin on palmitic acid-induced cytotoxicity in mouse brain endothelial cell
AIMS: The approximate prevalence of the metabolic syndrome (MS) in patients with coronary heart disease (CAD) is 50%, with a prevalence of 37% in patients with premature CAD. Effective prevention or treatment of MS significantly reduces the risk for developing serious complications. Palmitic acid (PA) is a saturated fatty acid, when being excessive, is a significant risk factor for development of MS or cardiovascular accident. Lipotoxicity in endothelial cells (EC) has been well documented but how PA ...postprin
The molecular mechanism of the anti-oxidative effects of catechin on palmitic acid-induced cytotoxicity in astrocytes
Poster PresentationAIMS: Metabolic syndrome (MS) encompasses a group of problems which will put a person at a high risk of developing cardiovascular diseases, including heart attack and stroke. Effective prevention or treatment of MS significantly reduces the risk for developing serious complications. Palmitic acid (PA) is a saturated fatty acid, when being excessive, is a significant risk factor for development of MS or stroke. However, damage by MS to astrocytes is relatively unexplored. Catechin is an effective antioxidant which would be beneficial to neurons subjected to reactive oxygen species (ROS) damage as well ...postprin
The cardioprotective effect of isosteviol on endothelin-1-induced hypertrophy of cultured neonatal rat cardiomyocytes
Poster Session - P307 Molecular and Cellular Cardiology, Basic Research: no. 1525 ; abstract no. 276AIMS: Isosteviol is an active derivative of stevioside and also possessing an anti-hypertensive effect in our previous report. Left ventricular hypertrophy is an independent cardiovascular risk factor related to cardiovascular complications in patients with hypertension. Therefore, a decrease in left ventricular mass is a therapeutic goal in these patients. In the present study, we elucidate the anti-hypertrophy and molecular mechanisms of isosteviol on endothelin-1(ET-1)-induced hyper…postprin
Study of B -> \rho \pi decays at Belle
This paper describes a study of B meson decays to the pseudoscalar-vector
final state \rho\pi using 31.9\times 10^6 B\bar{B} events collected with the
Belle detector at KEKB. The branching fractions B(B^+ \to \rho^0\pi^+) =
(8.0^{+2.3+0.7}_{-2.0-0.7}) \times 10^{-6} and B(B^0 -> \rho^{+-} \pi^{-+}) =
(20.8^{+6.0+2.8}_{-6.3-3.1}) \times 10^{-6} are obtained. In addition, a 90%
confidence level upper limit of B(B^0 \to \rho^0\pi^0) < 5.3 \times 10^{-6}is
reported.Comment: 14 pages, 3 figures, to be submitted to Phys. Lett.
Discordance of Intraoperative Frozen Section Analysis with Definitive Histology of Sentinel Lymph Nodes in Breast Cancer Surgery: Complementary Axillary Lymph Node Dissection is Irrelevant for Subsequent Systemic Therapy
Parity-Violating Electron Scattering from 4He and the Strange Electric Form Factor of the Nucleon
We have measured the parity-violating electroweak asymmetry in the elastic
scattering of polarized electrons from ^4He at an average scattering angle
= 5.7 degrees and a four-momentum transfer Q^2 = 0.091 GeV^2. From
these data, for the first time, the strange electric form factor of the nucleon
G^s_E can be isolated. The measured asymmetry of A_PV = (6.72 +/- 0.84 (stat)
+/- 0.21 (syst) parts per million yields a value of G^s_E = -0.038 +/- 0.042
(stat) +/- 0.010 (syst), consistent with zero
GLOBAL STABILITY AND BIFURCATIONS ANALYSIS OF AN EPIDEMIC MODEL WITH CONSTANT REMOVAL RATE OF THE INFECTIVE
In this thesis we consider an epidemic model with a constant removal rate of infective individuals is proposed to understand the effect of limited resources for treatment of infective on the disease spread. It is found that it is unnecessary to take such a large treatment capacity that endemic equilibria disappear to eradicate the disease. It is shown that the outcome of disease spread may depend on the position of the initial states for certain range of parameters. It is also shown that the model undergoes a sequence of bifurcations including saddle-node bifurcation, subcritical Hopf bifurcation. Keyword: Epidemic model, nonlinear incidence rate, basic reproduction number, local and global stabilit
Immunological Basis for the Gender Differences in Murine Paracoccidioides brasiliensis Infection
This study aimed to investigate the immunological mechanisms involved in the gender distinct incidence of paracoccidioidomycosis (pcm), an endemic systemic mycosis in Latin America, which is at least 10 times more frequent in men than in women. Then, we compared the immune response of male and female mice to Paracoccidioides brasiliensis infection, as well as the influence in the gender differences exerted by paracoccin, a P. brasiliensis component with carbohydrate recognition property. High production of Th1 cytokines and T-bet expression have been detected in the paracoccin stimulated cultures of spleen cells from infected female mice. In contrast, in similar experimental conditions, cells from infected males produced higher levels of the Th2 cytokines and expressed GATA-3. Macrophages from male and female mice when stimulated with paracoccin displayed similar phagocytic capability, while fungicidal activity was two times more efficiently performed by macrophages from female mice, a fact that was associated with 50% higher levels of nitric oxide production. In order to evaluate the role of sexual hormones in the observed gender distinction, we have utilized mice that have been submitted to gonadectomy followed by inverse hormonal reconstitution. Spleen cells derived from castrated males reconstituted with estradiol have produced higher levels of IFN-γ (1291±15 pg/mL) and lower levels of IL-10 (494±38 pg/mL), than normal male in response to paracoccin stimulus. In contrast, spleen cells from castrated female mice that had been treated with testosterone produced more IL-10 (1284±36 pg/mL) and less IFN-γ (587±14 pg/mL) than cells from normal female. In conclusion, our results reveal that the sexual hormones had a profound effect on the biology of immune cells, and estradiol favours protective responses to P. brasiliensis infection. In addition, fungal components, such as paracoccin, may provide additional support to the gender dimorphic immunity that marks P. brasiliensis infection
- …