Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease

A previous study from our laboratory revealed that moderate nigral dopaminergic degeneration caused emotional and cognitive deficits in rats, paralleling early signs of Parkinson's disease. Recent evidence suggests that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease. Here, we investigated whether antagonism of CB1 receptors would improve emotional and cognitive deficits in a rat model of premotor Parkinson's disease. Depression-like behavior and cognition were assessed with the forced swim test and the social recognition test, respectively. Confirming our previous study, rats injected with 6-hydroxydopamine in striatum presented emotional and cognitive alterations which were improved by acute injection of SR141716A. HPLC analysis of monoamine levels demonstrated alterations in the striatum and prefrontal cortex after SR141716A injection. These findings suggest a role for CB1 receptors in the early symptoms caused by degeneration of dopaminergic neurons in the striatum, as observed in Parkinson's disease

The fundamental parameters of the roAp star 10 Aql

Due to the strong magnetic field and related abnormal surface layers existing in rapidly oscillating Ap stars, systematic errors are likely to be present when determining their effective temperatures, which potentially compromises asteroseismic studies of these pulsators. Using long-baseline interferometry, our goal is to determine accurate angular diameters of a number of roAp targets to provide a temperature calibration for these stars. We obtained interferometric observations of 10 Aql with the visible spectrograph VEGA at the CHARA array. We determined a limb-darkened angular diameter of 0.275+/-0.009 mas and deduced a linear radius of 2.32+/-0.09 R_sun. We estimated the star's bolometric flux and used it, in combination with its parallax and angular diameter, to determine the star's luminosity and effective temperature. For two data sets of bolometric flux we derived an effective temperature of 7800+/-170 K and a luminosity of 18+/-1 L_sun or of 8000+/-210 K and 19+/-2 L_sun. We used these fundamental parameters together with the large frequency separation to constrain the mass and the age of 10 Aql, using the CESAM stellar evolution code. Assuming a solar chemical composition and ignoring all kinds of diffusion and settling of elements, we obtained a mass of 1.92 M_sun and an age of 780 Gy or a mass of 1.95 M_sun and an age of 740 Gy, depending on the considered bolometric flux. For the first time, we managed to determine an accurate angular diameter for a star smaller than 0.3 mas and to derive its fundamental parameters. In particular, by only combining our interferometric data and the bolometric flux, we derived an effective temperature that can be compared to those derived from atmosphere models. Such fundamental parameters can help for testing the mechanism responsible for the excitation of the oscillations observed in the magnetic pulsating stars

Signatures of magnetic activity in the seismic data of solar-type stars observed by Kepler

In the Sun, the frequencies of the acoustic modes are observed to vary in phase with the magnetic activity level. These frequency variations are expected to be common in solar-type stars and contain information about the activity-related changes that take place in their interiors. The unprecedented duration of Kepler photometric time-series provides a unique opportunity to detect and characterize stellar magnetic cycles through asteroseismology. In this work, we analyze a sample of 87 solar-type stars, measuring their temporal frequency shifts over segments of length 90 days. For each segment, the individual frequencies are obtained through a Bayesian peak-bagging tool. The mean frequency shifts are then computed and compared with: 1) those obtained from a cross-correlation method; 2) the variation in the mode heights; 3) a photometric activity proxy; and 4) the characteristic timescale of the granulation. For each star and 90-d sub-series, we provide mean frequency shifts, mode heights, and characteristic timescales of the granulation. Interestingly, more than 60% of the stars show evidence for (quasi-)periodic variations in the frequency shifts. In the majority of the cases, these variations are accompanied by variations in other activity proxies. About 20% of the stars show mode frequencies and heights varying approximately in phase, in opposition to what is observed for the Sun.Comment: Accepted for publication in ApJS, 19(+86) pages, 11(+89) figures, 2(+87) table

Seismic signatures of magnetic activity in solar-type stars observed by Kepler

The properties of the acoustic modes are sensitive to magnetic activity. The unprecedented long-term Kepler photometry, thus, allows stellar magnetic cycles to be studied through asteroseismology. We search for signatures of magnetic cycles in the seismic data of Kepler solar-type stars. We find evidence for periodic variations in the acoustic properties of about half of the 87 analysed stars. In these proceedings, we highlight the results obtained for two such stars, namely KIC 8006161 and KIC 5184732.Comment: 4 pages, 1 figure, to appear in the Proceedings of the IAUS34

Detailed numerical simulation of cathode spots in high-current vacuum arcs

A detailed numerical model of cathode spots in high-current vacuum arcs is given. The model provides a complete description of all phases of life of an individual spot taking into account the presence of metal vapor left over from a previous explosion, the interaction of the vaporized plasma from the cathode spot with the cathode surface, and Joule heat generation in the cathode body. Melting and motion of molten metal due to Lorentz force are also accounted for, together with surface tension effects and the pressure exerted by the plasma over the cathode surface. First results are presented and analyzed for copper cathodes with a protrusion and planar cathodes. Emphasis is given to the investigation of the effect of the vaporized plasma and of hydrodynamic processes. No thermal runaway is observed.info:eu-repo/semantics/publishedVersio

Simulating changes in shape of thermionic cathodes during operation of high-pressure arc discharges

A numerical model of current transfer to thermionic cathodes of high-pressure arc discharges is developed with account of deviations from local thermodynamic equilibrium occurring near the cathode surface, in particular, of the near-cathode space-charge sheath, melting of the cathode, and motion of the molten metal under the effect of the plasma pressure, the Lorentz force, gravity, and surface tension. Modelling results are reported for a tungsten cathode of an atmospheric-pressure argon arc and the computed changes in the shape of the cathode closely resemble those observed in the experiment. The modelling has shown that the time scale of change of the cathode shape during arc operation is very sensitive to the temperature attained by the cathode. The fact that the computed time scales conform to those observed in the experiment indicate that the model of non-equilibrium near-cathode layers in high pressure arc discharges, employed in this work, predicts the cathode temperature for a given arc current with adequate accuracy. In contrast, modelling based on the assumption of local thermodynamic equilibrium in the whole arc plasma computation domain up to the cathode surface could hardly produce a similar agreement.info:eu-repo/semantics/publishedVersio

Detailed numerical simulation of cathode spots in vacuum arcs: Interplay of different mechanisms and ejection of droplets

A model of cathode spots in high-current vacuum arcs is developed with account of all the poten tially relevant mechanisms: the bombardment of the cathode surface by ions coming from a pre existing plasma cloud; vaporization of the cathode material in the spot, its ionization, and the inter action of the produced plasma with the cathode; the Joule heat generation in the cathode body; melting of the cathode material and motion of the melt under the effect of the plasma pressure and the Lorentz force and related phenomena. After the spot has been ignited by the action of the cloud (which takes a few nanoseconds), the metal in the spot is melted and accelerated toward the periph ery of the spot, with the main driving force being the pressure due to incident ions. Electron emis sion cooling and convective heat transfer are dominant mechanisms of cooling in the spot, limiting the maximum temperature of the cathode to approximately 4700–4800 K. A crater is formed on the cathode surface in this way. After the plasma cloud has been extinguished, a liquid-metal jet is formed and a droplet is ejected. No explosions have been observed. The modeling results conform to estimates of different mechanisms of cathode erosion derived from the experimental data on the net and ion erosion of copper cathodes.info:eu-repo/semantics/publishedVersio