Radar Estimation of Intense Rainfall Rates through Adaptive Calibration of the Z-R Relation

Rainfall intensity estimation from weather radar is still significantly uncertain, due to local anomalies, radar beam attenuation, inappropriate calibration of the radar reflectivity factor (Z) to rainfall rate (R) relationship, and sampling errors. The aim of this work is to revise the use of the power-law equation commonly adopted to relate radar reflectivity and rainfall rate to increase the estimation quality in the presence of intense rainfall rates. We introduce a quasi real-time procedure for an adaptive in space and time estimation of the Z-R relation. The procedure is applied in a comprehensive case study, which includes 16 severe rainfall events in the north-west of Italy. The study demonstrates that the technique outperforms the classical estimation methods for most of the analysed events. The determination coefficient improves by up to 30% and the bias values for stratiform events decreases by up to 80% of the values obtained with the classical, non-adaptive, Z-R relations. The proposed procedure therefore shows significant potential for operational uses

INP MMIC AMPLIFIERS FOR CRYOGENIC RADIOASTRONOMICAL APPLICATIONS

Abstract Radioastronomical observation development, pushes technology research to develop equipment working up to 100-150 GHz. This trend make heavier the Low noise Amplifiers (LNA) noise contribution. A significantly improvement comes from the Indium Phosphide (InP) Technology, that gives the best noise performances in this range. Moreover radioastronomy moves also towards array receivers configuration, this implies high integration and repeatability. In the frame of the FARADAY PROJECT we were involved in designing several kind of MMIC amplifiers in the 18 to 26 GHz range in order to approach the InP technology and the MMIC design methodology

Dropout and completion in higher education in Europe: main report

Improving completion and reducing dropout in higher education are key concerns for higher education in Europe. This study on dropout and completion in higher education in Europe demonstrates that national governments and higher education institutions use three different study success objectives: completion, time-to-degree and retention. To address these objectives policy makers at national and institutional level apply various policy instruments. These can be categorized under three main policy headings: financial incentives; information and support for students; and organizational issues. The evidence indicates that countries that have more explicit study success objectives, targets and policies are likely to be more successful. Particularly if the policy approach is comprehensive and consistent. As such, it is important that study success is an issue in the information provision to (prospective) students, in financial incentives for students and institutions, in quality assurance, and in the education pathways offered to students. Furthermore, increasing the responsibility of higher education institutions for study success, for example in the area of selecting, matching, tracking, counselling, mentoring and integrating students in academic life is clearly effective. Finally, to support the policy debate and monitoring of study success evidence, there is a need for more systematic international comparative data and thorough analysis of the effectiveness of study success policie

Gestational zinc deficiency impairs brain astrogliogenesis in rats through multistep alterations of the JAK/STAT3 signaling pathway

We previously showed that zinc (Zn) deficiency affects the STAT3 signaling pathway in part through redox-regulated mechanisms. Given that STAT3 is central to the process of astrogliogenesis, this study investigated the consequences of maternal marginal Zn deficiency on the developmental timing and key mechanisms of STAT3 activation, and its consequences on astrogliogenesis in the offspring. This work characterized the temporal profile of cortical STAT3 activation from the mid embryonic stage up to young adulthood in the offspring from dams fed a marginal Zn deficient diet (MZD) throughout gestation and until postnatal day (P) 2. All rats were fed a Zn sufficient diet (control) from P2 until P56. Maternal zinc deficiency disrupted cortical STAT3 activation at E19 and P2. This was accompanied by altered activation of JAK2 kinase due to changes in PTP1B phosphatase activity. The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation. Zn deficiency-associated decreased STAT3 activation adversely impacted astrogliogenesis, leading to a lower astrocyte number in the early postnatal and adult brain cortex. Thus, a decreased availability of Zn during early development can have a major and irreversible adverse effect on astrogliogenesis, in part via multistep alterations in the STAT3 pathway.Fil: Supasai, Suangsuda. University of California at Davis; Estados UnidosFil: Adamo, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Mathieu, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Marino, Regina C.. University of California at Davis; Estados UnidosFil: Hellmers, Adelaide C.. University of California at Davis; Estados UnidosFil: Cremonini, Eleonora. University of California at Davis; Estados UnidosFil: Oteiza, Patricia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin

Gestational zinc deficiency impairs brain astrogliogenesis in rats through multistep alterations of the JAK/STAT3 signaling pathway

We previously showed that zinc (Zn) deficiency affects the STAT3 signaling pathway in part through redox-regulated mechanisms. Given that STAT3 is central to the process of astrogliogenesis, this study investigated the consequences of maternal marginal Zn deficiency on the developmental timing and key mechanisms of STAT3 activation, and its consequences on astrogliogenesis in the offspring. This work characterized the temporal profile of cortical STAT3 activation from the mid embryonic stage up to young adulthood in the offspring from dams fed a marginal Zn deficient diet (MZD) throughout gestation and until postnatal day (P) 2. All rats were fed a Zn sufficient diet (control) from P2 until P56. Maternal zinc deficiency disrupted cortical STAT3 activation at E19 and P2. This was accompanied by altered activation of JAK2 kinase due to changes in PTP1B phosphatase activity. The underlying mechanisms mediating the adverse impact of a decreased Zn availability on STAT3 activation in the offspring brain include: (i) impaired PTP1B degradation via the ubiquitin/proteasome pathway; (ii) tubulin oxidation, associated decreased interactions with STAT3 and consequent impaired nuclear translocation; and (iii) decreased nuclear STAT3 acetylation. Zn deficiency-associated decreased STAT3 activation adversely impacted astrogliogenesis, leading to a lower astrocyte number in the early postnatal and adult brain cortex. Thus, a decreased availability of Zn during early development can have a major and irreversible adverse effect on astrogliogenesis, in part via multistep alterations in the STAT3 pathway.Fil: Supasai, Suangsuda. University of California at Davis; Estados UnidosFil: Adamo, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Mathieu, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Marino, Regina C.. University of California at Davis; Estados UnidosFil: Hellmers, Adelaide C.. University of California at Davis; Estados UnidosFil: Cremonini, Eleonora. University of California at Davis; Estados UnidosFil: Oteiza, Patricia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin