587 research outputs found
A Review of Sociological Issues in Fire Safety Regulation
This paper presents an overview of contemporary sociological issues in fire safety. The most obviously social aspects of fire safetyβthose that relate to the socioeconomic distribution of fire casualties and damageβare discussed first. The means that society uses to mitigate fire risks through regulation are treated next; focusing on the shift towards fire engineered solutions and the particular challenges this poses for the social distribution and communication of fire safety knowledge and expertise. Finally, the social construction of fire safety knowledge is discussed, raising questions about whether the confidence in the application of this knowledge by the full range of participants in the fire safety design and approvals process is always justified, given the specific assumptions involved in both the production of the knowledge and its extension to applications significantly removed from the original knowledge production; and the requisite competence that is therefore needed to apply this knowledge. The overarching objective is to argue that the fire safety professions ought to be more reflexive and informed about the nature of the knowledge and expertise that they develop and apply, and to suggest that fire safety scientists and engineers ought to actively collaborate with social scientists in research designed to study the way people interact with fire safety technology
A pragmatic cluster randomised trial evaluating three implementation interventions
Background
Implementation research is concerned with bridging the gap between evidence and practice through the study of methods to promote the uptake of research into routine practice. Good quality evidence has been summarised into guideline recommendations to show that peri-operative fasting times could be considerably shorter than patients currently experience. The objective of this trial was to evaluate the effectiveness of three strategies for the implementation of recommendations about peri-operative fasting.
Methods
A pragmatic cluster randomised trial underpinned by the PARIHS framework was conducted during 2006 to 2009 with a national sample of UK hospitals using time series with mixed methods process evaluation and cost analysis. Hospitals were randomised to one of three interventions: standard dissemination (SD) of a guideline package, SD plus a web-based resource championed by an opinion leader, and SD plus plan-do-study-act (PDSA). The primary outcome was duration of fluid fast prior to induction of anaesthesia. Secondary outcomes included duration of food fast, patients' experiences, and stakeholders' experiences of implementation, including influences. ANOVA was used to test differences over time and interventions.
Results
Nineteen acute NHS hospitals participated. Across timepoints, 3,505 duration of fasting observations were recorded. No significant effect of the interventions was observed for either fluid or food fasting times. The effect size was 0.33 for the web-based intervention compared to SD alone for the change in fluid fasting and was 0.12 for PDSA compared to SD alone. The process evaluation showed different types of impact, including changes to practices, policies, and attitudes. A rich picture of the implementation challenges emerged, including inter-professional tensions and a lack of clarity for decision-making authority and responsibility.
Conclusions
This was a large, complex study and one of the first national randomised controlled trials conducted within acute care in implementation research. The evidence base for fasting practice was accepted by those participating in this study and the messages from it simple; however, implementation and practical challenges influenced the interventions' impact. A set of conditions for implementation emerges from the findings of this study, which are presented as theoretically transferable propositions that have international relevance. Trial registration ISRCTN18046709 - Peri-operative Implementation Study Evaluation (POISE
A possible doseΓ’β¬βresponse association between distance to farmersΓ’β¬β’ markets and roadside produce stands, frequency of shopping, fruit and vegetable consumption, and body mass index among customers in the Southern United States
Background: The association between farmersΓ’β¬β’ market characteristics and consumer shopping habits remains
unclear. Our objective was to examine associations among distance to farmersΓ’β¬β’ markets, amenities within farmersΓ’β¬β’
markets, frequency of farmersΓ’β¬β’ market shopping, fruit and vegetable consumption, and body mass index (BMI). We
hypothesized that the relationship between frequency of farmersΓ’β¬β’ market shopping and BMI would be mediated by
fruit and vegetable consumption.
Methods: In 15 farmersΓ’β¬β’ markets in northeastern North Carolina, JulyΓ’β¬βSeptember 2015, we conducted a crosssectional
survey among 263 farmersΓ’β¬β’ market customers (199 provided complete address data) and conducted
farmersΓ’β¬β’ market audits. To participate, customers had to be over 18 years of age, and English speaking. Dependent
variables included farmersΓ’β¬β’ market shopping frequency, fruit and vegetable consumption, and BMI. Analysis of
variance, adjusted multinomial logistic regression, Poisson regression, and linear regression models, adjusted for
age, race, sex, and education, were used to examine associations between distance to farmersΓ’β¬β’ markets, amenities
within farmersΓ’β¬β’ markets, frequency of farmersΓ’β¬β’ market shopping, fruit and vegetable consumption, and BMI.
Results: Those who reported shopping at farmersΓ’β¬β’ markets a few times per year or less reported consuming 4.4
(standard deviation = 1.7) daily servings of fruits and vegetables, and those who reported shopping 2 or more times
per week reported consuming 5.5 (2.2) daily servings. There was no association between farmersΓ’β¬β’ market amenities,
and shopping frequency or fruit and vegetable consumption. Those who shopped 2 or more times per week had a
statistically significantly lower BMI than those who shopped less frequently. There was no evidence of mediation of
the relationship between frequency of shopping and BMI by fruit and vegetable consumption.
Conclusions: More work should be done to understand factors within farmersΓ’β¬β’ markets that encourage fruit and
vegetable purchases.ECU Open Access Publishing Support Fun
Primordial Black Holes: sirens of the early Universe
Primordial Black Holes (PBHs) are, typically light, black holes which can
form in the early Universe. There are a number of formation mechanisms,
including the collapse of large density perturbations, cosmic string loops and
bubble collisions. The number of PBHs formed is tightly constrained by the
consequences of their evaporation and their lensing and dynamical effects.
Therefore PBHs are a powerful probe of the physics of the early Universe, in
particular models of inflation. They are also a potential cold dark matter
candidate.Comment: 21 pages. To be published in "Quantum Aspects of Black Holes", ed. X.
Calmet (Springer, 2014
Lost & Found Dark Matter in Elliptical Galaxies
There is strong evidence that the mass in the Universe is dominated by dark
matter, which exerts gravitational attraction but whose exact nature is
unknown. In particular, all galaxies are believed to be embedded in massive
haloes of dark matter. This view has recently been challenged by surprisingly
low random stellar velocities in the outskirts of ordinary elliptical galaxies,
which were interpreted as indicating a lack of dark matter (Mendez et al. 2001;
Romanowsky et al. 2003). Here we show that the low velocities are in fact
compatible with galaxy formation in dark-matter haloes. Using numerical
simulations of disc-galaxy mergers, we find that the stellar orbits in the
outer regions of the resulting ellipticals are very elongated. These stars were
torn by tidal forces from their original galaxies during the first close
passage and put on outgoing trajectories. The elongated orbits, combined with
the steeply falling density profile of the observed tracers, explain the
observed low velocities even in the presence of large amounts of dark matter.
Projection effects when viewing a triaxial elliptical can lead to even lower
observed velocities along certain lines of sight.Comment: Letter to Nature, 13+15 pages, 2+11 figures, improved text, extended
Supplementary Information adde
Molecular Phylogeny of the Acanthocephala (Class Palaeacanthocephala) with a Paraphyletic Assemblage of the Orders Polymorphida and Echinorhynchida
Acanthocephalans are attractive candidates as model organisms for studying the ecology and co-evolutionary history of parasitic life cycles in the marine ecosystem. Adding to earlier molecular analyses of this taxon, a total of 36 acanthocephalans belonging to the classes Archiacanthocephala (3 species), Eoacanthocephala (3 species), Palaeacanthocephala (29 species), Polyacanthocephala (1 species) and Rotifera as outgroup (3 species) were analyzed by using Bayesian Inference and Maximum Likelihood analyses of nuclear 18S rDNA sequence. This data set included three re-collected and six newly collected taxa, Bolbosoma vasculosum from Lepturacanthus savala, Filisoma rizalinum from Scatophagus argus, Rhadinorhynchus pristis from Gempylus serpens, R. lintoni from Selar crumenophthalmus, Serrasentis sagittifer from Johnius coitor, and Southwellina hispida from Epinephelus coioides, representing 5 new host and 3 new locality records. The resulting trees suggest a paraphyletic arrangement of the Echinorhynchida and Polymorphida inside the Palaeacanthocephala. This questions the placement of the genera Serrasentis and Gorgorhynchoides within the Echinorhynchida and not the Polymorphida, necessitating further insights into the systematic position of these taxa based on morphology
Species-Specific Diversity of a Fixed Motor Pattern: The Electric Organ Discharge of Gymnotus
Understanding fixed motor pattern diversity across related species provides a window for exploring the evolution of their underlying neural mechanisms. The electric organ discharges of weakly electric fishes offer several advantages as paradigmatic models for investigating how a neural decision is transformed into a spatiotemporal pattern of action. Here, we compared the far fields, the near fields and the electromotive force patterns generated by three species of the pulse generating New World gymnotiform genus Gymnotus. We found a common pattern in electromotive force, with the far field and near field diversity determined by variations in amplitude, duration, and the degree of synchronization of the different components of the electric organ discharges. While the rostral regions of the three species generate similar profiles of electromotive force and local fields, most of the species-specific differences are generated in the main body and tail regions of the fish. This causes that the waveform of the field is highly site dependant in all the studied species. These findings support a hypothesis of the relative separation of the electrolocation and communication carriers. The presence of early head negative waves in the rostral region, a species-dependent early positive wave at the caudal region, and the different relationship between the late negative peak and the main positive peak suggest three points of lability in the evolution of the electrogenic system: a) the variously timed neuronal inputs to different groups of electrocytes; b) the appearance of both rostrally and caudally innervated electrocytes, and c) changes in the responsiveness of the electrocyte membrane
Phylogenetic Relationships in Pterodroma Petrels Are Obscured by Recent Secondary Contact and Hybridization
The classification of petrels (Pterodroma spp.) from Round
Island, near Mauritius in the Indian Ocean, has confounded researchers since
their discovery in 1948. In this study we investigate the relationships between
Round Island petrels and their closest relatives using evidence from
mitochondrial DNA sequence data and ectoparasites. Far from providing clear
delimitation of species boundaries, our results reveal that hybridization among
species on Round Island has led to genetic leakage between populations from
different ocean basins. The most common species on the island,
Pterodroma arminjoniana, appears to be hybridizing with two
rarer species (P. heraldica and P. neglecta),
subverting the reproductive isolation of all three and allowing gene flow.
P. heraldica and P. neglecta breed
sympatrically in the Pacific Ocean, where P. arminjoniana is
absent, but no record of hybridization between these two exists and they remain
phenotypically distinct. The breakdown of species boundaries in Round Island
petrels followed environmental change (deforestation and changes in species
composition due to hunting) within their overlapping ranges. Such multi-species
interactions have implications not only for conservation, but also for our
understanding of the processes of evolutionary diversification and
speciation
RNA localization in neurite morphogenesis and synaptic regulation: current evidence and novel approaches
It is now generally accepted that RNA localization in the central nervous system conveys important roles both during development and in the adult brain. Of special interest is protein synthesis located at the synapse, as this potentially confers selective synaptic modification and has been implicated in the establishment of memories. However, the underlying molecular events are largely unknown. In this review, we will first discuss novel findings that highlight the role of RNA localization in neurons. We will focus on the role of RNA localization in neurotrophin signaling, axon outgrowth, dendrite and dendritic spine morphogenesis as well as in synaptic plasticity. Second, we will briefly present recent work on the role of microRNAs in translational control in dendrites and its implications for learning and memory. Finally, we discuss recent approaches to visualize RNAs in living cells and their employment for studying RNA trafficking in neurons
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