The Association between Childhood Obesity and Cardiovascular Changes in 10 Years Using Special Data Science Analysis

The increasing prevalence of overweight and obesity is a worldwide problem, with several well-known consequences that might start to develop early in life during childhood. The present research based on data from children that have been followed since birth in a previously established cohort study (Generation XXI, Porto, Portugal), taking advantage of State-of-the-Art (SoA) data science techniques and methods, including Neural Architecture Search (NAS), explainable Artificial Intelligence (XAI), and Deep Learning (DL), aimed to explore the hidden value of data, namely on electrocardiogram (ECG) records performed during follow-up visits. The combination of these techniques allowed us to clarify subtle cardiovascular changes already present at 10 years of age, which are evident from ECG analysis and probably induced by the presence of obesity. The proposed novel combination of new methodologies and techniques is discussed, as well as their applicability in other health domains.João Rala Cordeiro received support from Fundação para a Ciência e Tecnologia (PhD Research Scholarship reference 2020.07443.BD)

Photocatalytic asphalt mixtures: semiconductors' impact in skid resistance and texture

Photocatalytic asphalt mixtures have the capability of mitigating air quality problems and degrade oils/greases by using semiconductors. The techniques to do so can change their functional characteristics. This study aimed to analyse the functionalization effect on the essential surface characteristics, such as macrotexture, skid resistance, and microtexture. AC 14 and AC 6 mixtures were functionalised with nano-TiO2 and micro-ZnO by spraying and bulk incorporation. Mean Profile Depth, British Pendulum and microtexture amplitude parameters were evaluated. TiO2 application seemed to smooth the surface slightly. In dry condition, the skid resistance of functionalised asphalt and control mixtures was similar. In wet condition, the functionalization caused a maximum decrease of 7% in skid resistance. The amplitude parameters were not affected by any functionalization technique except the skewness of AC 14 with 6% TiO2 by bulk incorporation. Furthermore, the application of the semiconductors can be used without high impacts in texture and skid resistance.This work was partially financed by FCT (Fundacao para a Ciencia e a Tecnologia) under the project [PTDC/FIS/120412/2010]: "Nanobased concepts for Innovative & Eco-sustainable constructive material's surfaces" and project [PEst-OE/ECI/UI4047/2014]. Also, the first author would like to acknowledge FCT for the PhD scholarship [SFRH/BD/137421/2018]

Trypanosoma rangeli is phylogenetically closer to Old World trypanosomes than to Trypanosoma cruzi.

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Trypanosoma rangeli and Trypanosoma cruzi are generalist trypanosomes sharing a wide range of mammalian hosts; they are transmitted by triatomine bugs, and are the only trypanosomes infecting humans in the Neotropics. Their origins, phylogenetic relationships, and emergence as human parasites have long been subjects of interest. In the present study, taxon-rich analyses (20 trypanosome species from bats and terrestrial mammals) using ssrRNA, glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH), heat shock protein-70 (HSP70) and Spliced Leader RNA sequences, and multilocus phylogenetic analyses using 11 single copy genes from 15 selected trypanosomes, provide increased resolution of relationships between species and clades, strongly supporting two main sister lineages: lineage Schizotrypanum, comprising T. cruzi and bat-restricted trypanosomes, and Tra[Tve-Tco] formed by T. rangeli, Trypanosoma vespertilionis and Trypanosoma conorhini clades. Tve comprises European T. vespertilionis and African T. vespertilionis-like of bats and bat cimicids characterised in the present study and Trypanosoma sp. Hoch reported in monkeys and herein detected in bats. Tco included the triatomine-transmitted tropicopolitan T. conorhini from rats and the African NanDoum1 trypanosome of civet (carnivore). Consistent with their very close relationships, Tra[Tve-Tco] species shared highly similar Spliced Leader RNA structures that were highly divergent from those of Schizotrypanum. In a plausible evolutionary scenario, a bat trypanosome transmitted by cimicids gave origin to the deeply rooted Tra[Tve-Tco] and Schizotrypanum lineages, and bat trypanosomes of diverse genetic backgrounds jumped to new hosts. A long and independent evolutionary history of T. rangeli more related to Old World trypanosomes from bats, rats, monkeys and civets than to Schizotrypanum spp., and the adaptation of these distantly related trypanosomes to different niches of shared mammals and vectors, is consistent with the marked differences in transmission routes, life-cycles and host-parasite interactions, resulting in T. cruzi (but not T. rangeli) being pathogenic to humans.This study was supported by grants awarded to MMGT and EPC from CNPq (National Council for Scientific and Technological Development) PROAFRICA, PROSUL and UNIVERSAL programs, CAPES (Coordination for the Improvement of Higher Education Personnel) PNIPB, PNPD and PROTAX programs, and FAPESP (São Paulo Research Foundation; process 2016/07487-0). Genome sequencing was supported by the Assembling the Tree of Life (ATOL) Project of the National Science Foundation, USA (NSF DEB-0830056), and TCC-USP (Trypanosomatid Culture Collection of the University of São Paulo) projects. OEA received PhD fellowships from CNPq (PROTAX) and COLCIENCIAS (Administrative Department of Science, Technology and Innovation, Colombia); PAO is a postdoctoral fellow of CAPES (PNPD); LL and AGCM are supported by a postdoctoral fellowship from CAPES (PROTAX)

Closed String Tachyons and Semi-Classical Instabilities

We conjecture that the end point of bulk closed string tachyon decay at any non-zero coupling, is the annihilation of space time by Witten's bubble of nothing, resulting in a topological phase of the theory. In support of this we present a variety of situations in which there is a correspondence between the existence of perturbative tachyons in one regime and the semi-classical annihilation of space-time. Our discussion will include many recently investigated scenarios in string theory including Scherk-Schwarz compactifications, Melvin magnetic backgrounds, and noncompact orbifolds. We use this conjecture to investigate a possible web of dualities relating the eleven-dimensional Fabinger-Horava background with nonsupersymmetric string theories. Along the way we point out where our conjecture resolves some of the puzzles associated with bulk closed string tachyon condensation.Comment: 31 pages, 5 figures 3 figures added, typos corrected and references added. Discussion of Type 0/Heterotic s-duality extended and some other points clarified Revision of discussion on Fabinger-Horava string descendents, section on Scherk-Schwarz compactification of Horava-Witten removed, some references adde

Accelerating Cold Dark Matter Cosmology (ΩΛ≡0\Omega_{\Lambda}\equiv 0)

A new kind of accelerating flat model with no dark energy that is fully dominated by cold dark matter (CDM) is investigated. The number of CDM particles is not conserved and the present accelerating stage is a consequence of the negative pressure describing the irreversible process of gravitational particle creation. A related work involving accelerating CDM cosmology has been discussed before the SNe observations [Lima, Abramo & Germano, Phys. Rev. D53, 4287 (1996)]. However, in order to have a transition from a decelerating to an accelerating regime at low redshifts, the matter creation rate proposed here includes a constant term of the order of the Hubble parameter. In this case, $H_0$ does not need to be small in order to solve the age problem and the transition happens even if the matter creation is negligible during the radiation and part of the matter dominated phase. Therefore, instead of the vacuum dominance at redshifts of the order of a few, the present accelerating stage in this sort of Einstein-de Sitter CDM cosmology is a consequence of the gravitational particle creation process. As an extra bonus, in the present scenario does not exist the coincidence problem that plagues models with dominance of dark energy. The model is able to harmonize a CDM picture with the present age of the universe, the latest measurements of the Hubble parameter and the Supernovae observations.Comment: 9 pages, 6 figures, typos corrected, references added, discussion in Appendix B extende

Can the evolution of music be analyzed in a quantitative manner?

We propose a methodology to study music development by applying multivariate statistics on composers characteristics. Seven representative composers were considered in terms of eight main musical features. Grades were assigned to each characteristic and their correlations were analyzed. A bootstrap method was applied to simulate hundreds of artificial composers influenced by the seven representatives chosen. Afterwards we quantify non-numeric relations like dialectics, opposition and innovation. Composers differences on style and technique were represented as geometrical distances in the feature space, making it possible to quantify, for example, how much Bach and Stockhausen differ from other composers or how much Beethoven influenced Brahms. In addition, we compared the results with a prior investigation on philosophy. Opposition, strong on philosophy, was not remarkable on music. Supporting an observation already considered by music theorists, strong influences were identified between composers by the quantification of dialectics, implying inheritance and suggesting a stronger master-disciple evolution when compared to the philosophy analysis.Comment: 8 pages, 6 figures, added references for sections 1 and 4.C, better mathematical description on section 2. New values and interpretation, now considering a bootstrap metho

Gravito-electromagnetic analogies

We reexamine and further develop different gravito-electromagnetic (GEM) analogies found in the literature, and clarify the connection between them. Special emphasis is placed in two exact physical analogies: the analogy based on inertial fields from the so-called "1+3 formalism", and the analogy based on tidal tensors. Both are reformulated, extended and generalized. We write in both formalisms the Maxwell and the full exact Einstein field equations with sources, plus the algebraic Bianchi identities, which are cast as the source-free equations for the gravitational field. New results within each approach are unveiled. The well known analogy between linearized gravity and electromagnetism in Lorentz frames is obtained as a limiting case of the exact ones. The formal analogies between the Maxwell and Weyl tensors are also discussed, and, together with insight from the other approaches, used to physically interpret gravitational radiation. The precise conditions under which a similarity between gravity and electromagnetism occurs are discussed, and we conclude by summarizing the main outcome of each approach.Comment: 60 pages, 2 figures. Improved version (compared to v2) with some re-write, notation improvements and a new figure that match the published version; expanded compared to the published version to include Secs. 2.3 and

Geometry of open strings ending on backreacting D3-branes

We investigate open string theory on backreacting D3-branes using a spacetime approach. We study in detail the half-BPS supergravity solutions describing open strings ending on D3-branes, in the near horizon of the D3-branes. We recover quantitatively several non-trivial features of open string physics including the appearance of D3-brane spikes, the polarization of fundamental strings into D5-branes, and the Hanany-Witten effect. Finally we detail the computation of the gravitational potential between two open strings, and contrast it with the holographic computation of Wilson lines. We argue that the D-brane backreaction has a large influence on the low-energy gravity, which may lead to experimental tests for string theory brane-world scenarios.Comment: 64 pages, 20 figure