Targeting neuroendocrine abnormalities in Parkinson’s disease with exercise

Parkinson’s Disease (PD) is a prevalent and complex age-related neurodegenerative condition for which there are no disease-modifying treatments currently available. The pathophysiological process underlying PD remains incompletely understood but increasing evidence points to multiple system dysfunction. Interestingly, the past decade has produced evidence that exercise not only reduces signs and symptoms of PD but is also potentially neuroprotective. Characterizing the mechanistic pathways that are triggered by exercise and lead to positive outcomes will improve understanding of how to counter disease progression and symptomatology. In this review, we highlight how exercise regulates the neuroendocrine system, whose primary role is to respond to stress, maintain homeostasis and improve resilience to aging. We focus on a group of hormones – cortisol, melatonin, insulin, klotho, and vitamin D – that have been shown to associate with various non-motor symptoms of PD, such as mood, cognition, and sleep/circadian rhythm disorder. These hormones may represent important biomarkers to track in clinical trials evaluating effects of exercise in PD with the aim of providing evidence that patients can exert some behavioral-induced control over their disease

Cross-taxon congruence between predatory arthropods and plants across Mediterranean agricultural landscapes

Although arthropods are among the most diverse, abundant and ecologically important animals in terrestrial ecosystems, they are generally neglected in most biodiversity inventories due to their complex systematics and overwhelming diversity, coupled with the current decline in the number of taxonomists. For this reason, several surrogate groups for arthropod diversity have been proposed, with plants being identified as a good putative cross-taxon indicator. By sampling plants and three groups of ground-dwelling arthropods (rove beetles, ground beetles and spiders) in 300 sites across 15 landscapes including multiple semi-natural and agricultural habitats, we tested for habitat-dependence and scale-dependence in the cross-taxon congruence. Plant species richness was a poor predictor of the species richness of predatory arthropods. Among the predator groups, ground beetles appeared as the best potential surrogate for the other ground-dwelling predators. This is backed by the fact that ground beetles were extremely diverse and abundant in all habitats and are usually easier to identify than both rove beetles and spiders. Decreasing the scale at which the cross-taxon congruence was tested improved the strength of the cross-taxon congruence. Although plant species richness was not a suitable indicator for the diversity of predatory arthropods, vegetation structure played a significant role in influencing cross-taxon congruence in both natural and agricultural habitats. Our results highlight the need to explore the cross-taxon relationships at a fine habitat resolution scale, as strong correlations were obtained only by taking into account habitat identity

Wideband planar skirt antenna and its application for the detection of terahertz radiation

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Design of a wide-bandwidth on-chip antenna for uncooled passive THz imaging

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The uses of coherent structure (Dryden Lecture)

The concept of coherent structure in turbulent flow is a revolutionary idea which is being developed by evolutionary means. The main objective of this review is to list some solid achievements, showing what can be done by using the concept of coherent structure that cannot be done without it. The nature of structure is described in terms of some related concepts, including celerity, topology, and the phenomenon of coalescence and splitting of structure. The main emphasis is on the mixing layer, as the one flow whose structure is well enough understood so that technical applications are now being made in problems of mixing and chemistry. An attempt is made to identify some conceptual and experimental obstacles that stand in the way of progress in other technically important flows, particularly the turbulent boundary layer. A few comments are included about the role of structure in numerical simulations and in current work on manipulation and control of turbulent flow. Some recent developments are cited which suggest that the time is nearly right for corresponding advances to occur in turbulence modeling