Controlled-release oxycodone and pregabalin in the treatment of neuropathic pain: results of a multicenter Italian study

Abstract AIMS: The aim of our study was to compare the efficacy, safety, and quality of life of combination therapy with controlled-release (CR) oxycodone plus pregabalin versus monotherapy with either CR oxycodone or pregabalin in patients with neuropathic pain. MATERIALS AND METHODS: Patients with moderate to severe neuropathic pain, despite the use of various pharmacologic treatments prior to study entry, were enrolled (n = 409) and treated with CR oxycodone plus pregabalin (n = 169), CR oxycodone (n = 106), and pregabalin (n = 134). Pain intensity was rated on an 11-point numerical rating scale (NRS). RESULTS: The combination of CR oxycodone plus pregabalin and CR oxycodone monotherapy were both more effective for alleviating neuropathic pain than pregabalin monotherapy (reduction in NRS value: 80, 76, and 46%, respectively; p </= 0.003). Significantly greater improvements from baseline in quality of life were reported with combination therapy than with monotherapy (p = 0.0009). At the end of treatment, the majority (91.2%) of patients receiving CR oxycodone plus pregabalin found that the treatment had been 'effective' or 'very effective'. Combination therapy also allowed a dose reduction of both agents (22% for CR oxycodone and 51% for pregabalin) compared with the dosages of the respective monotherapies. Combination therapy had a superior safety profile compared with pregabalin monotherapy. CONCLUSIONS: The combination of CR oxycodone plus pregabalin may represent a valuable addition to the existing pharmacotherapy for neuropathic pain and warrants further investigation

Gerir a diversidade: contributos da aprendizagem cooperativa para a construção de salas de aula inclusivas

The action-research we have held at the primary education, in a school placed near the town of Tomar, in 2009-2010, under the master's degree in Special Education, was the starting point for writing this article. The research had as main objective to promote the successful learning of a heterogeneous group of students, where a child considered with longstanding special educational needs is included – diagnosis of galactosaemia and cognitive impairment. Starting from the educational context of a particular classroom of 2nd and 3rd grades, where we were working as special education teacher, we had created an inclusive learning environment for each student in the class. Through effective collaboration between fellow teachers, we generated changes in methodologies, breaking with some traditional practices in the classroom, when regular teachers and special education are in the same learning space. By a systematic implementation of cooperative learning strategies among students, and applying qualitative data gathering techniques of research, before and after the intervention – interview, naturalistic observation, sociometry and documental research –, we have increased the quality and quantity of learning and promoted another way of ‘looking to’ the difference

Riflettanza di superfici vulcaniche:la campagna 2003 sul Monte Etna

The results obtained in Mt. Etna spectroradiometric field survey of June 2003 are presented and discussed. The goal of the survey was the analysis of the reflectance properties of the young pyroclastic deposits produced after the effusive activity of 2002-2003 and of the older lava flows. To achieve this goal, a template was created in order to organize the field data collected in a number of selected sites characterised by different surface materials. The results show that reflectance of pyroclastic flows is always very low and constant, besides grain size and composition of the flow. Pahoehoe units show higher reflectance values, even though the spectral characterisation of the older lava flows must take into account weathering products and vegetation coverage

A photographic dataset of the coseismic geological effects induced on the environment by the 2012 Emilia (Northern Italy) earthquake sequence

We present a collection of pictures of the coseismic secondary geological effects produced on the environment by the 2012 Emilia seismic sequence in northern Italy. The May-June 2012 sequence struck a broad area located in the Po Plain region, causing 26 deaths and hundreds of injured, 15.000 homeless, severe damage of historical centres and industrial areas, and an estimated economic toll of ~2 billion of euros. The sequence included two mainshocks (Figure 1): the first one, with ML 5.9, occurred on May 20 between Finale Emilia, S. Felice sul Panaro and S. Martino Spino; the second one, with ML 5.8, occurred 12 km southwest of the previous mainshock on May 29. Both the mainshocks occurred on about E-W trending, S dipping blind thrust faults; the whole aftershocks area extends in an E-W direction for more than 50 km and includes five ML≥5.0 events and more than 1800 ML>1.5 events. Ground cracks and liquefactions were certainly the most relevant coseismic geological effects observed during the Emilia sequence. In particular, extensive liquefaction was observed over an area of ~1200 km2 following the May 20 and May 29 events. We collected all the coseismic geological evidence through field survey, helicopter and powered hang-glider trike survey, and reports from local people directly checked in the field. On the basis of their morphologic and structural characteristics the 1362 effects surveyed were grouped into three main categories: a) liquefactions related to overpressure of aquifers, occurring through several aligned vents forming coalescent flat cones (485 effects); b) liquefactions with huge amounts of liquefied sand and fine sand ejected from fractures tens of meters long (768); c) extensional fractures with small vertical throws, apparently organized in an en-echelon pattern, with no effects of liquefaction (109). The photographic dataset consists of 99 pictures of coseismic geological effects observed in 17 localities concentrated in the epicentral area. The pictures are sorted and presented by locality of observation; each photo reports several information such as the name of the site, the geographical coordinates and the type of effect observed. Figure 1 shows a map of the pictures sites along with the location of the two mainshocks; Figure 2 shows a detail of the distribution of the liquefactions in the area of S. Carlo. The complete description of the coseismic geological effects induced by the Emilia sequence, their relation with the aftershock area, the InSAR deformation area and the I>6 EMS felt area, along with the description of the technologies used for data sourcing and processing are shown in Emergeo Working Group [2012a and 2012b].Published1-703.2. Tettonica attivaN/A or not JCRope

Technologies and new approaches used by the INGV EMERGEO Working Group for real-time data sourcing and processing during the Emilia Romagna (northern Italy) 2012 earthquake sequence

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Rilievi geologici nell’area epicentrale della sequenza sismica dell’Aquilano del 6 aprile 2009

Il 6 Aprile 2009 un terremoto di Ml=5.8 (Mw=6.2) ha colpito L’Aquila e la media valle dell’Aterno in Abruzzo. In questo lavoro presentiamo in maniera sintetica i rilievi geologici effettuati in campagna dal gruppo di lavoro EmerGeo a seguito della sequenza sismica aquilana. Le attività di rilevamento condotte sono consistite principalmente nella verifica, definizione e caratterizzazione delle deformazioni cosismiche superficiali osservate lungo le strutture tettoniche note in letteratura; sono stati inoltre rilevati e riportati altri effetti cosismici locali (fratture su asfalto, frane e scivolamenti) non direttamente collegati alla presenza di strutture tettoniche. In totale sono stati rilevati oltre 300 punti di osservazione su una porzione di territorio estesa circa 900 km2. L’analisi preliminare dei rilievi effettuati indica che le rotture osservate lungo la faglia di Paganica, per la continuità e le caratteristiche, rappresentano l’espressione superficiale della faglia responsabile dell’evento del 6 aprile 2009, e che le rotture lungo le faglie di Bazzano e di Monticchio-Fossa possono rappresentare l’espressione in superficie di una struttura antitetica riattivata durante l’evento