The genomics of neonatal abstinence syndrome

Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids. Since maternal opioid dose does not appear to correlate directly with neonatal outcome, maternal, placental, and fetal genomic variants may play important roles in NAS. Previous studies in small cohorts have demonstrated associations of variants in maternal and infant genes that encode the μ-opioid receptor (OPRM1), catechol-O-methyltransferase (COMT), and prepronociceptin (PNOC) with a shorter length of hospital stay and less need for treatment in neonates exposed to opioids in utero. Consistently falling genomic sequencing costs and computational approaches to predict variant function will permit unbiased discovery of genomic variants and gene pathways associated with differences in maternal and fetal opioid pharmacokinetics and pharmacodynamics and with placental opioid transport and metabolism. Discovery of pathogenic variants should permit better delineation of the risk of developing more severe forms of NAS. This review provides a summary of the current role of genomic factors in the development of NAS and suggests strategies for further genomic discovery

The cosmological origin of the Tully-Fisher relation

We use high-resolution cosmological simulations that include the effects of gasdynamics and star formation to investigate the origin of the Tully-Fisher relation in the standard Cold Dark Matter cosmogony. Luminosities are computed for each model galaxy using their full star formation histories and the latest spectrophotometric models. We find that at z=0 the stellar mass of model galaxies is proportional to the total baryonic mass within the virial radius of their surrounding halos. Circular velocity then correlates tightly with the total luminosity of the galaxy, reflecting the equivalence between mass and circular velocity of systems identified in a cosmological context. The slope of the relation steepens slightly from the red to the blue bandpasses, and is in fairly good agreement with observations. Its scatter is small, decreasing from \~0.45 mag in the U-band to ~0.34 mag in the K-band. The particular cosmological model we explore here seems unable to account for the zero-point of the correlation. Model galaxies are too faint at z=0 (by about two magnitudes) if the circular velocity at the edge of the luminous galaxy is used as an estimator of the rotation speed. The Tully-Fisher relation is brighter in the past, by about ~0.7 magnitudes in the B-band at z=1, at odds with recent observations of z~1 galaxies. We conclude that the slope and tightness of the Tully-Fisher relation can be naturally explained in hierarchical models but that its normalization and evolution depend strongly on the star formation algorithm chosen and on the cosmological parameters that determine the universal baryon fraction and the time of assembly of galaxies of different mass.Comment: 5 pages, 4 figures included, submitted to ApJ (Letters

Dark Halo and Disk Galaxy Scaling Laws in Hierarchical Universes

We use cosmological N-body/gasdynamical simulations that include star formation and feedback to examine the proposal that scaling laws between the total luminosity, rotation speed, and angular momentum of disk galaxies reflect analogous correlations between the structural parameters of their surrounding dark matter halos. The numerical experiments follow the formation of galaxy-sized halos in two Cold Dark Matter dominated universes: the standard Omega=1 CDM scenario and the currently popular LCDM model. We find that the slope and scatter of the I-band Tully-Fisher relation are well reproduced in the simulations, although not, as proposed in recent work, as a result of the cosmological equivalence between halo mass and circular velocity: large systematic variations in the fraction of baryons that collapse to form galaxies and in the ratio between halo and disk circular velocities are observed in our numerical experiments. The Tully-Fisher slope and scatter are recovered in this model as a direct result of the dynamical response of the halo to the assembly of the luminous component of the galaxy. We conclude that models that neglect the self-gravity of the disk and its influence on the detailed structure of the halo cannot be used to derive meaningful estimates of the scatter or slope of the Tully-Fisher relation. Our models fail, however, to match the zero-point of the Tully-Fisher relation, as well as that of the relation linking disk rotation speed and angular momentum. These failures can be traced, respectively, to the excessive central concentration of dark halos formed in the Cold Dark Matter cosmogonies we explore and to the formation of galaxy disks as the final outcome of a sequence of merger events. (abridged)Comment: submitted to The Astrophysical Journa

Analytical modeling of the structureborne noise path on a small twin-engine aircraft

The structureborne noise path of a six passenger twin-engine aircraft is analyzed. Models of the wing and fuselage structures as well as the interior acoustic space of the cabin are developed and used to evaluate sensitivity to structural and acoustic parameters. Different modeling approaches are used to examine aspects of the structureborne path. These approaches are guided by a number of considerations including the geometry of the structures, the frequency range of interest, and the tractability of the computations. Results of these approaches are compared with experimental data

Dark-Halo Cusp: Asymptotic Convergence

We propose a model for how the buildup of dark halos by merging satellites produces a characteristic inner cusp, of a density profile \rho \prop r^-a with a -> a_as > 1, as seen in cosmological N-body simulations of hierarchical clustering scenarios. Dekel, Devor & Hetzroni (2003) argue that a flat core of a<1 exerts tidal compression which prevents local deposit of satellite material; the satellite sinks intact into the halo center thus causing a rapid steepening to a>1. Using merger N-body simulations, we learn that this cusp is stable under a sequence of mergers, and derive a practical tidal mass-transfer recipe in regions where the local slope of the halo profile is a>1. According to this recipe, the ratio of mean densities of halo and initial satellite within the tidal radius equals a given function psi(a), which is significantly smaller than unity (compared to being 1 according to crude resonance criteria) and is a decreasing function of a. This decrease makes the tidal mass transfer relatively more efficient at larger a, which means steepening when a is small and flattening when a is large, thus causing converges to a stable solution. Given this mass-transfer recipe, linear perturbation analysis, supported by toy simulations, shows that a sequence of cosmological mergers with homologous satellites slowly leads to a fixed-point cusp with an asymptotic slope a_as>1. The slope depends only weakly on the fluctuation power spectrum, in agreement with cosmological simulations. During a long interim period the profile has an NFW-like shape, with a cusp of 1<a<a_as. Thus, a cusp is enforced if enough compact satellite remnants make it intact into the inner halo. In order to maintain a flat core, satellites must be disrupted outside the core, possibly as a result of a modest puffing up due to baryonic feedback.Comment: 37 pages, Latex, aastex.cls, revised, ApJ, 588, in pres

Temperature Anisotropies and Distortions Induced by Hot Intracluster Gas on the Cosmic Microwave Background

The power spectrum of temperature anisotropies induced by hot intracluster gas on the cosmic background radiation is calculated. For low multipoles it remains constant while at multipoles above $l>2000$ it is exponentially damped. The shape of the radiation power spectrum is almost independent of the average intracluster gas density profile, gas evolution history or clusters virial radii; but the amplitude depends strongly on those parameters and could be as large as 20% that of intrinsic contribution. The exact value depends on the global properties of the cluster population and the evolution of the intracluster gas. The distortion on the Cosmic Microwave Background black body spectra varies in a similar manner. The ratio of the temperature anisotropy to the mean Comptonization parameters is shown to be almost independent of the cluster model and, in first approximation, depends only on the number density of clusters.Comment: 10 pages, Latex, 3 figures; to be published in Ap

Dark Matter Scaling Relations

We establish the presence of a dark matter core radius, for the first time in a very large number of spiral galaxies of all luminosities. Contrary to common opinion we find that the sizes of these cores and the " DM core problem" are bigger for more massive spirals. As a result the Burkert profile provides an excellent mass model for dark halos around disk galaxies. Moreover, we find that the spiral dark matter core densities $\rho_{0}$ and core radii $r_{0}$ lie in the same scaling relation $\rho_{0}=4.5\times 10^-2 (r_{0}/kpc)^{-2/3} M_{\odot}pc^{-3}$ of dwarf galaxies with core radii upto ten times more smaller.Comment: 4 pages, 4 figures, Accepted for Publication in Apj Let

Self-similar collapse and the structure of dark matter halos: A fluid approach

We explore the dynamical restrictions on the structure of dark matter halos through a study of cosmological self-similar gravitational collapse solutions. A fluid approach to the collisionless dynamics of dark matter is developed and the resulting closed set of moment equations are solved numerically including the effect of halo velocity dispersions (both radial and tangential), for a range of spherically averaged initial density profiles. Our results highlight the importance of tangential velocity dispersions to obtain density profiles shallower than $1/r^2$ in the core regions, and for retaining a memory of the initial density profile, in self-similar collapse. For an isotropic core velocity dispersion only a partial memory of the initial density profile is retained. If tangential velocity dispersions in the core are constrained to be less than the radial dispersion, a cuspy core density profile shallower than $1/r$ cannot obtain, in self-similar collapse.Comment: 25 pages, 7 figures, submitted to Ap

Substructure Boosts to Dark Matter Annihilation from Sommerfeld Enhancement

The recently introduced Sommerfeld enhancement of the dark matter annihilation cross section has important implications for the detection of dark matter annihilation in subhalos in the Galactic halo. In addition to the boost to the dark matter annihilation cross section from the high densities of these subhalos with respect to the main halo, an additional boost caused by the Sommerfeld enhancement results from the fact that they are kinematically colder than the Galactic halo. If we further believe the generic prediction of CDM that in each subhalo there is an abundance of substructure which is approximately self-similar to that of the Galactic halo, then I show that additional boosts coming from the density enhancements of these small substructures and their small velocity dispersions enhance the dark matter annihilation cross section even further. I find that very large boost factors ($10^5$ to $10^9$) are obtained in a large class of models. The implications of these boost factors for the detection of dark matter annihilation from dwarf Spheroidal galaxies in the Galactic halo are such that, generically, they outshine the background gamma-ray flux and are detectable by the Fermi Gamma-ray Space Telescope.Comment: PRD in pres

Global Alfven Eigenmodes in the H-1 heliac

Recent upgrades in H-1 power supplies have enabled the operation of the H-1 experiment at higher heating powers than previously attainable. A heating power scan in mixed hydrogen/helium plasmas reveals a change in mode activity with increasing heating power. At low power (<50 kW) modes with beta-induced Alfven eigenmode (BAE) frequency scaling are observed. At higher power modes consistent with an analysis of nonconventional Global Alfven Eigenmodes (GAEs) are observed, the subject of this work. We have computed the mode continuum, and identified GAE structures using the ideal MHD solver CKA and the gyrokinetic code EUTERPE. An analytic model for ICRH-heated minority ions is used to estimate the fast ion temperature from the hydrogen species. Linear growth rate scans using a local flux surface stability calculation, LGRO, are performed. These studies demonstrate growth from circulating particles whose speed is significantly less than the Alfven speed, and are resonant with the mode through harmonics of the Fourier decomposition of the strongly-shaped heliac magnetic field. They reveal drive is possible with a small, hot energetic tail of the hydrogen species. Local linear growth rate scans are also complemented with global calculations from CKA and EUTERPE. These qualitatively confirm the findings from the LGRO study, and show that the inclusion of finite Larmor radius effects can reduce the growth rate by a factor of three, but do not affect marginal stability. Finally, a study of damping of the global mode with the thermal plasma is conducted, computing continuum, and the damping arising from parallel electric fields. We find that continuum damping is of order 0.1% for the configuration studied. The inclusion of resistivity lifts the damping to 19%. Such large damping is consistent with experimental observations that in absence of drive the mode decays rapidly (~0.1 ms).Comment: 18 pages, 15 figures, submitted 07/04/2017 to Plasma Physics and Controlled Fusio