Anti-infective surface coatings: design and therapeutic promise against device-associated infections

Patient safety and well-being are under increasing threat from hospital-acquired infections [1]. The root cause of a large number of these infections arises from microbial biofilms that colonise on surfaces of medical devices such as the millions of catheters, endotracheal tubes, and prosthetics implanted every year [2]. Biofilm infections are accompanied by increased resistance to antimicrobial therapy and immune clearance, severely limiting treatment options and leading to life-threatening disease [3,4]. Device-associated infections are caused by both bacteria and fungi and, while most studies have focused on single-species biofilms, biofilm-related infections are often polymicrobial [5–8]. Multi-species biofilms, particularly those involving bacterial and fungal pathogens, are more challenging to treat, likely as a consequence of their combined architecture, protective extracellular matrix, and potential synergism in protecting against antimicrobials and host immunity [9–11]. Among the fungi, Candida species are the most important biofilm pathogens [12,13] and the fourth leading cause of blood-stream infections in United States hospitals [7]. Fungal diseases remain difficult to diagnose, mortality rates remain high, and antifungal drug resistance continues to limit therapeutic options [14,15]. We are in desperate need of innovative strategies that target the mechanisms of pathogenesis of polymicrobial biofilms on medical devices. This is a grand challenge because it requires multidisciplinary collaboration and breakthrough research involving physical chemistry, materials science, and microbiology. Communication between these disciplines has not been common, but recent advances show greater convergence in the development of anti-infective devices. At this nexus, we outline the therapeutic promise of anti-infective coatings for medical devices and discuss pitfalls and strategies for overcoming them.Bryan R. Coad, Hans J. Griesser, Anton Y. Peleg, Ana Trave

Pattern languages in HCI: A critical review

This article presents a critical review of patterns and pattern languages in human-computer interaction (HCI). In recent years, patterns and pattern languages have received considerable attention in HCI for their potential as a means for developing and communicating information and knowledge to support good design. This review examines the background to patterns and pattern languages in HCI, and seeks to locate pattern languages in relation to other approaches to interaction design. The review explores four key issues: What is a pattern? What is a pattern language? How are patterns and pattern languages used? and How are values reflected in the pattern-based approach to design? Following on from the review, a future research agenda is proposed for patterns and pattern languages in HCI

First record of Rhinogobius similis, Gill 1895 In Iran

This is the first record of Rhinogobius similis (Gobiidae), an exotic fish species in Iran. The results of this study show that a limited number of this species live in Harir-rud on Iran, Torkman Border. The morphometric and morphological characters of this species in Iran are similar to these from Japan and Korea

A substrate-independent method for surface grafting polymer layers by atom transfer radical polymerization: reduction of protein adsorption

Available online 11 October 2011Abstract not availableBryan R. Coad, Yi Lu, Laurence Meaghe

Historical roots of Agile methods: where did “Agile thinking” come from?

The appearance of Agile methods has been the most noticeable change to software process thinking in the last fifteen years [16], but in fact many of the “Agile ideas” have been around since 70’s or even before. Many studies and reviews have been conducted about Agile methods which ascribe their emergence as a reaction against traditional methods. In this paper, we argue that although Agile methods are new as a whole, they have strong roots in the history of software engineering. In addition to the iterative and incremental approaches that have been in use since 1957 [21], people who criticised the traditional methods suggested alternative approaches which were actually Agile ideas such as the response to change, customer involvement, and working software over documentation. The authors of this paper believe that education about the history of Agile thinking will help to develop better understanding as well as promoting the use of Agile methods. We therefore present and discuss the reasons behind the development and introduction of Agile methods, as a reaction to traditional methods, as a result of people's experience, and in particular focusing on reusing ideas from histor

Low-energy magnetic response of the noncentrosymmetric heavy-fermion superconductor CePt3Si studied via inelastic neutron scattering

The low-energy magnetic excitations of the noncentrosymmetric heavy-fermion superconductor CePt3Si have been measured with inelastic neutron scattering on a single crystal. Kondo-type spin fluctuations with an anisotropic wave vector dependence are observed in the paramagnetic state. These fluctuations do not survive in the antiferromagnetically ordered state below TN=2.2 K but are replaced by damped spin waves, whose dispersion is much stronger along the c-axis than in other directions. No change is observed in the excitation spectrum or the magnetic order as the system enters the superconducting state below Tc=0.7 K.Comment: Revised version: 8 pages, 7 figure

Business experience and start-up size: buying more lottery tickets next time around?

This paper explores the determinants of start-up size by focusing on a cohort of 6247 businesses that started trading in 2004, using a unique dataset on customer records at Barclays Bank. Quantile regressions show that prior business experience is significantly related with start-up size, as are a number of other variables such as age, education and bank account activity. Quantile treatment effects (QTE) estimates show similar results, with the effect of business experience on (log) start-up size being roughly constant across the quantiles. Prior personal business experience leads to an increase in expected start-up size of about 50%. Instrumental variable QTE estimates are even higher, although there are concerns about the validity of the instrument

An Exercise in Reverse Engineering for Safety-Critical Systems: An Experience for the Classroom

Since the Y2K crisis, reverse engineering has become a major area of work in industrial software application development, but lacks emphasis in US academia. This issue is exemplified by the high demand for software systems in new and expanding software application areas, which has resulted in systems being implemented before the requirements and design phases have been completed. Towards the maintenance of such systems, it is necessary to conducted reverse engineering for the derivation of software documentation for requirements and high-level and low-level design. When this scenario exists in the domain of safety-critical system, particularly in the aviation industry, reverse engineering takes on greater value because such software systems have to undergo development regulations and certification restrictions. This work reports on the pedagogical revelations gained from conducting reverse engineering on a software system that was developed and deployed for use in managing the assignment of commercial aircrafts to airport terminal gates. The software system incorporated genetic algorithms solutions and was implemented on a high-speed multi-processor system. The reverse engineering methodology applied was based on the RTCA DO-178C Software Considerations in Airborne Systems and Equipment Certification specification for onboard avionic software systems

Polyethyleneimine for copper absorption: kinetics, selectivity and efficiency in artificial seawater

Published on 29 May 2014.Polyethyleneimine (PEI) is known to bind copper ions effectively and selectively. However, this is the first report on PEI-based materials for copper scavenging from ultra-low concentrations in seawater matrixes. The findings are relevant for water purification and sensing applications as well as extraction of copper from oceans.Johan B. Lindén, Mikael Larsson, Bryan R. Coad, William M. Skinner and Magnus Nydé