Structure and origin of the J Anomaly Ridge, western North Atlantic Ocean

Author Posting. © American Geophysical Union, 1982. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 87, no. B11 (1982): 9389–9407, doi:10.1029/JB087iB11p09389.The J Anomaly Ridge is a structural ridge or step in oceanic basement that extends southwest from the eastern end of the Grand Banks. It lies beneath the J magnetic anomaly at the young end (M-4 to M-0) of the M series magnetic anomalies. Its structural counterpart beneath the J anomaly in the eastern Atlantic is the Madeira-Tore Rise, but this feature has been overprinted by post-middle Cretaceous deformation and volcanism. In order to study the origin and evolution of the J Anomaly Ridge-Madeira-Tore Rise system, we obtained seismic refraction and multichannel reflection profiles across the J Anomaly Ridge near 39°N latitude. The western ridge flank consists of a series of crustal blocks downdropped along west-dipping normal faults, but the eastern slope to younger crust is gentle and relatively unfaulted. The western flank also is subparallel to seafloor isochrons, becoming younger to the south. Anomalously smooth basement caps the ridge crest, and it locally exhibits internal, eastward-dipping reflectors similar in configuration to those within subaerially emplaced basalt flows on Iceland. When isostatically corrected for sediment load, the northern part of the J Anomaly Ridge has basement depths about 1400 m shallower than in our study area, and deep sea drilling has shown that the northern ridge was subaerially exposed during the middle Cretaceous. We suggest that most of the system originated under subaerial conditions at the time of late-stage rifting between the adjacent Grand Banks and Iberia. The excess magma required to form the ridge may have been vented from a mantle plume beneath the Grand Banks-Iberia rift zone and channelled southward beneath the rift axis of the abutting Mid-Atlantic Ridge. Resulting edifice-building volcanism constructed the ridge system between anomalies M-4 and M-0, moving southward along the ridge axis at about 50 mm/yr. About M-0 time, when true drift began between Iberia and the Grand Banks, this southward venting rapidly declined. The results were rapid return of the spreading axis to normal elevations, division of the ridge system into the separate J Anomaly Ridge and Madeira-Tore Rise, and unusually fast subsidence of at least parts of these ridges to depths that presently are near normal. This proposed origin and evolutionary sequence for the J Anomaly Ridge-Madeira-Tore Rise system closely matches events of uplift and unconformity development on the adjacent Grand Banks.This research was supported by the Office of Naval Research, contracts N00014-75-C-0210 and N00014-80-C-0098 to Lamont-Doherty Geological Observatory and contract N00014-79-C-0071 to Woods Hole Oceanographic Institution

A novel emergency department based prevention intervention program for people living with HIV: evaluation of early experiences

<p>Abstract</p> <p>Background</p> <p>HIV prevention is increasingly focused on people living with HIV (PLWH) and the role of healthcare settings in prevention. Emergency Departments (EDs) frequently care for PLWH, but do not typically endorse a prevention mission. We conducted a pilot exploratory evaluation of the first reported ED program to address the prevention needs of PLWH.</p> <p>Methods</p> <p>This retrospective observational cohort evaluation reviewed program records to describe the first six months of participants and programmatic operation. Trained counselors provided a risk assessment and counseling intervention combined with three linkage interventions: i) linkage to health care, ii) linkage to case management, and iii) linkage to partner counseling and referral.</p> <p>Results</p> <p>Of 81 self-identified PLWH who were approached, 55 initially agreed to participate. Of those completing risk assessment, 17/53 (32%, 95 CI 20% to 46%) reported unprotected anal/vaginal intercourse or needle sharing in the past six months with a partner presumed to be HIV negative. Counseling was provided to 52/53 (98%). For those requesting services, 11/15 (73%) were linked to healthcare, 4/23 (17%) were coordinated with case management, and 1/4 (25%) completed partner counseling and referral.</p> <p>Conclusion</p> <p>Given base resources of trained counselors, it was feasible to implement a program to address the prevention needs for persons living with HIV in an urban ED. ED patients with HIV often have unmet needs which might be addressed by improved linkage with existing community resources. Healthcare and prevention barriers for PLWH may be attenuated if EDs were to incorporate CDC recommended prevention measures for healthcare providers.</p

Post-mortem volatiles of vertebrate tissue

Volatile emission during vertebrate decay is a complex process that is understood incompletely. It depends on many factors. The main factor is the metabolism of the microbial species present inside and on the vertebrate. In this review, we combine the results from studies on volatile organic compounds (VOCs) detected during this decay process and those on the biochemical formation of VOCs in order to improve our understanding of the decay process. Micro-organisms are the main producers of VOCs, which are by- or end-products of microbial metabolism. Many microbes are already present inside and on a vertebrate, and these can initiate microbial decay. In addition, micro-organisms from the environment colonize the cadaver. The composition of microbial communities is complex, and communities of different species interact with each other in succession. In comparison to the complexity of the decay process, the resulting volatile pattern does show some consistency. Therefore, the possibility of an existence of a time-dependent core volatile pattern, which could be used for applications in areas such as forensics or food science, is discussed. Possible microbial interactions that might alter the process of decay are highlighted

The Drosophila melanogaster host model

The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen–host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial–host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis–host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed

Projecting Land-Use Change and Its Consequences for Biodiversity in Northern Thailand

Rapid deforestation has occurred in northern Thailand over the last few decades and it is expected to continue. The government has implemented conservation policies aimed at maintaining forest cover of 50% or more and promoting agribusiness, forestry, and tourism development in the region. The goal of this paper was to analyze the likely effects of various directions of development on the region. Specific objectives were (1) to forecast land-use change and land-use patterns across the region based on three scenarios, (2) to analyze the consequences for biodiversity, and (3) to identify areas most susceptible to future deforestation and high biodiversity loss. The study combined a dynamic land-use change model (Dyna-CLUE) with a model for biodiversity assessment (GLOBIO3). The Dyna-CLUE model was used to determine the spatial patterns of land-use change for the three scenarios. The methodology developed for the Global Biodiversity Assessment Model framework (GLOBIO 3) was used to estimate biodiversity intactness expressed as the remaining relative mean species abundance (MSA) of the original species relative to their abundance in the primary vegetation. The results revealed that forest cover in 2050 would mainly persist in the west and upper north of the region, which is rugged and not easily accessible. In contrast, the highest deforestation was expected to occur in the lower north. MSA values decreased from 0.52 in 2002 to 0.45, 0.46, and 0.48, respectively, for the three scenarios in 2050. In addition, the estimated area with a high threat to biodiversity (an MSA decrease >0.5) derived from the simulated land-use maps in 2050 was approximately 2.8% of the region for the trend scenario. In contrast, the high-threat areas covered 1.6 and 0.3% of the region for the integrated-management and conservation-oriented scenarios, respectively. Based on the model outcomes, conservation measures were recommended to minimize the impacts of deforestation on biodiversity. The model results indicated that only establishing a fixed percentage of forest was not efficient in conserving biodiversity. Measures aimed at the conservation of locations with high biodiversity values, limited fragmentation, and careful consideration of road expansion in pristine forest areas may be more efficient to achieve biodiversity conservation. © 2010 Springer Science+Business Media, LLC

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Copy number variants (CNVs) are major contributors to genomic imbalance disorders. Phenotyping of 137 unrelated deletion and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are associated with autism spectrum disorders and mirror phenotypes of obesity/underweight and macrocephaly/microcephaly. Such phenotypes were previously associated with rearrangements of the non-overlapping proximal 16p11.2 600 kb BP4-BP5 interval. These two CNV-prone regions at 16p11.2 are reciprocally engaged in complex chromatin looping, as successfully confirmed by 4C-seq, fluorescence in situ hybridization and Hi-C, as well as coordinated expression and regulation of encompassed genes. We observed that genes differentially expressed in 16p11.2 BP4-BP5 CNV carriers are concomitantly modified in their chromatin interactions, suggesting that disruption of chromatin interplays could participate in the observed phenotypes. We also identified cis- and trans-acting chromatin contacts to other genomic regions previously associated with analogous phenotypes. For example, we uncovered that individuals with reciprocal rearrangements of the trans-contacted 2p15 locus similarly display mirror phenotypes on head circumference and weight. Our results indicate that chromosomal contacts’ maps could uncover functionally and clinically related genes.Molecular Psychiatry advance online publication, 31 May 2016; doi:10.1038/mp.2016.84

City of Norwich, Conn. 1876.

Perspective map not drawn to scale.Bird's-eye-view.LC Panoramic maps (2nd ed.), 91Includes illus., index to points of interest, and list of government officials for 1876 and 1784