A two-compartment model for understanding the simulated three-dimensional circulation in Prince William Sound, Alaska

A two-compartment model of Prince William Sound (PWS), Alaska, is developed, One compartment, corresponding to the southern PWS, represents advective phenomena, while the other is dominated by diffusion, This simple model is shown to reproduce rather well the temporal evolution of the mass of a passive tracer contained in PWS simulated by a complex, three-dimensional model under five types of surface forcing, The three parameters of the box-model have clear physical meanings, which helps to understand the hydrodynamics of PWS, In particular, the fraction of the flow entering the northern PWS is estimated, as well as the turnover time of the two regions considered. (C) 1998 Elsevier Science Ltd. All rights reserve

A historical perspective on milestones in multiple myeloma research

The first well-documented case of multiple myeloma was reported in 1844 by Samuel Solly. In this article, the author presents a historical review of the disease. In particular, the review is focused on the main steps, including the definition of Bence Jones proteinuria, the characterization of tumoral plasma cells and serum globulins, and the fundamental contribution of Jan Waldenstrom. Finally, treatment of multiple myeloma, as well as the development of new agents, is discussed

A new two-way nesting technique for ocean modeling based on the smoothed semi-prognostic method

A new two-way nesting technique is presented for a multiple nested-grid ocean modeling system. The new technique uses the smoothed semi-prognostic (SSP) method to exchange information between the different subcomponents of the nested-grid system. Four versions of the new nesting technique are described, together with conventional one-way nesting. The performance of the different nesting techniques is compared, using two independent nested-grid modeling systems, one for the Scotian Shelf of the northwest Atlantic Ocean and the other for the Meso-American Barrier Reef System of the northwestern Caribbean Sea. Nesting using the semi-prognostic method is shown to effectively prevent unrealistic drift of the inner model, while use of the SSP method avoids unnecessary damping of small scales on the inner model grid. Comparison of the annual-mean flow field with the near-surface currents determined by Fratantoni (in J Geophys Res 106:2977–2996, 2001) from observed trajectories of near-surface drifters demonstrates the overall superiority of the nesting technique based on the SSP method

A numerical study of the circulation and monthly-to-seasonal variability in the Caribbean Sea: the role of Caribbean eddies

This study examines the circulation and associated monthly-to-seasonal variability in the Caribbean Sea using a regional ocean circulation model. The model domain covers the region between 99.0 and 54.0°W and between 8.0 and 30.3°N, with a horizontal resolution of 1/6°. The ocean circulation model is driven by 6-hourly atmospheric reanalysis data from the National Center for Environmental Prediction and boundary forcing extracted from 5-day global ocean reanalysis data produced by Smith et al. (Mercator Newsletter 36:39–49, 2010), and integrated for 7 years. A comparison of model results with observations demonstrates that the regional ocean circulation model has skill in simulating circulation and associated variability in the study region. Analysis of the model results, as well as a companion model run that uses steady annual mean forcing, illustrates the role of Caribbean eddies for driving monthly-to-seasonal circulation variability in the model. It is found that vertically integrated transport between Nicaragua and Jamaica is influenced by the interaction between the density perturbations associated with Caribbean eddies and the Nicaraguan Ridge. The impact of Caribbean eddies squeezing through the Yucatan Channel is also discussed