40 research outputs found
Czynno艣膰 i hemodynamika prawej po艂owy serca w nadci艣nieniu p艂ucnym
G艂贸wnym wyzwaniem w leczeniu pacjent贸w z zaawansowanym t臋tniczym nadci艣nieniem p艂ucnym
(PAH) jest dysfunkcja prawej komory (RV), kt贸ra wi膮偶e si臋 z wyst臋powaniem prawokomorowej
niewydolno艣ci serca. Prze偶ywalno艣膰 w tej chorobie 艣ci艣le wi膮偶e si臋 z czynno艣ci膮 prawej
po艂owy serca, kt贸rej ocena budzi rosn膮ce zainteresowanie. Cho膰 echokardiografia i rezonans
magnetyczny serca (CMR) zwi臋kszy艂y mo偶liwo艣ci obrazowania RV, g艂贸wnym sposobem oceny
czynno艣ci prawej po艂owy serca pozostaje jego inwazyjne cewnikowanie. Wykazano, 偶e kilka
obecnie dost臋pnych sposob贸w leczenia PAH wp艂ywa na RV, a nie tylko na naczynia p艂ucne,
natomiast w przysz艂o艣ci metody terapeutyczne maj膮ce na celu optymalizacj臋 czynno艣ci RV
mog膮 pozwoli膰 na popraw臋 rokowania w tej trudnej do leczenia chorobie. Nowe kierunki oceny
RV i kr膮偶enia ma艂ego, w tym pomiar impedancji naczy艅 p艂ucnych, oraz powszechniejsza
dost臋pno艣膰 CMR mog膮 si臋 przyczyni膰 do rozwoju wiedzy na temat prawej po艂owy serca - dotychczas
s艂abo zbadanej, ale niezwykle wa偶nej
Vasodilator Responses to the Endomorphin Peptides, but Not Nociceptin/OFQ, Are Mediated by Nitric Oxide Release
Vegetation diversity and role of Leptadenia pyrotechnica in biomass contribution and carbon storage in arid zone of India
The emergency room transfusion score (ETS): prediction of blood transfusion requirement in initial resuscitation after severe trauma
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Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice.
To study the role of early energetic abnormalities in the subsequent development of heart failure, we performed serial in vivo combined magnetic resonance imaging (MRI) and (31)P magnetic resonance spectroscopy (MRS) studies in mice that underwent pressure-overload following transverse aorta constriction (TAC). After 3 wk of TAC, a significant increase in left ventricular (LV) mass (74 +/- 4 vs. 140 +/- 26 mg, control vs. TAC, respectively; P < 0.000005), size [end-diastolic volume (EDV): 48 +/- 3 vs. 61 +/- 8 microl; P < 0.005], and contractile dysfunction [ejection fraction (EF): 62 +/- 4 vs. 38 +/- 10%; P < 0.000005] was observed, as well as depressed cardiac energetics (PCr/ATP: 2.0 +/- 0.1 vs. 1.3 +/- 0.4, P < 0.0005) measured by combined MRI/MRS. After an additional 3 wk, LV mass (140 +/- 26 vs. 167 +/- 36 mg; P < 0.01) and cavity size (EDV: 61 +/- 8 vs. 76 +/- 8 microl; P < 0.001) increased further, but there was no additional decline in PCr/ATP or EF. Cardiac PCr/ATP correlated inversely with end-systolic volume and directly with EF at 6 wk but not at 3 wk, suggesting a role of sustained energetic abnormalities in evolving chamber dysfunction and remodeling. Indeed, reduced cardiac PCr/ATP observed at 3 wk strongly correlated with changes in EDV that developed over the ensuing 3 wk. These data suggest that abnormal energetics due to pressure overload predict subsequent LV remodeling and dysfunction