2,209 research outputs found
Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation
We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus monotherapy in 26 consecutive pediatric kidney transplant recipients between January 2004 and December 2005. Mean recipient age was 10.7 ± 5.8 years, 7.7% were undergoing retransplantation, and 3.8% were sensitized, with a PRA >20%. Mean donor age was 32.8 ± 9.2 years. Living donors were utilized in 65% of the transplants. Mean cold ischemia time was 27.6 ± 6.4 h. The mean number of HLA mismatches was 3.3 ± 1.3. Mean follow-up was 25 ± 8 months. One and 2 year patient survival was 100% and 96%. One and 2 year graft survival was 96% and 88%. Mean serum creatinine was 1.1 ± 0.6 mg/dL, and calculated creatinine clearance was 82.3 ± 29.4 mL/min/1.73 m 2. The incidence of pre-weaning acute rejection was 11.5%; the incidence of delayed graft function was 7.7%. Eighteen (69%) of the children were tapered to spaced tacrolimus monotherapy, 10.5 ± 2.2 months after transplantation. The incidence of CMV, PTLD and BK virus was 0%; the incidence of posttransplant diabetes was 7.7%. Although more follow-up is clearly needed, antibody pre-conditioning with alemtuzumab and tacrolimus monotherapy may be a safe and effective regimen in pediatric renal transplantation. © 2007 The Authors
Higher-order scalar interactions and SM vacuum stability
Investigation of the structure of the Standard Model effective potential at
very large field strengths opens a window towards new phenomena and can reveal
properties of the UV completion of the SM. The map of the lifetimes of the
vacua of the SM enhanced by nonrenormalizable scalar couplings has been
compiled to show how new interactions modify stability of the electroweak
vacuum. Whereas it is possible to stabilize the SM by adding Planck scale
suppressed interactions and taking into account running of the new couplings,
the generic effect is shortening the lifetime and hence further destabilisation
of the SM electroweak vacuum. These findings have been illustrated with phase
diagrams of modified SM-like models. It has been demonstrated that
stabilisation can be achieved by lowering the suppression scale of higher order
operators while picking up such combinations of new couplings, which do not
deepen the new minima of the potential. Our results show the dependence of the
lifetime of the electroweak minimum on the magnitude of the new couplings,
including cases with very small couplings (which means very large effective
suppression scale) and couplings vastly different in magnitude (which
corresponds to two different suppression scales).Comment: plain Latex, 9 figure
Skyrmion Multi-Walls
Skyrmion walls are topologically-nontrivial solutions of the Skyrme system
which are periodic in two spatial directions. We report numerical
investigations which show that solutions representing parallel multi-walls
exist. The most stable configuration is that of the square -wall, which in
the limit becomes the cubically-symmetric Skyrme crystal. There is
also a solution resembling parallel hexagonal walls, but this is less stable.Comment: 7 pages, 1 figur
Phenomenology and Cosmology of an Electroweak Pseudo-Dilaton and Electroweak Baryons
In many strongly-interacting models of electroweak symmetry breaking the
lowest-lying observable particle is a pseudo-Goldstone boson of approximate
scale symmetry, the pseudo-dilaton. Its interactions with Standard Model
particles can be described using a low-energy effective nonlinear chiral
Lagrangian supplemented by terms that restore approximate scale symmetry,
yielding couplings of the pseudo-dilaton that differ from those of a Standard
Model Higgs boson by fixed factors. We review the experimental constraints on
such a pseudo-dilaton in light of new data from the LHC and elsewhere. The
effective nonlinear chiral Lagrangian has Skyrmion solutions that may be
identified with the `electroweak baryons' of the underlying
strongly-interacting theory, whose nature may be revealed by the properties of
the Skyrmions. We discuss the finite-temperature electroweak phase transition
in the low-energy effective theory, finding that the possibility of a
first-order electroweak phase transition is resurrected. We discuss the
evolution of the Universe during this transition and derive an
order-of-magnitude lower limit on the abundance of electroweak baryons in the
absence of a cosmological asymmetry, which suggests that such an asymmetry
would be necessary if the electroweak baryons are to provide the cosmological
density of dark matter. We revisit estimates of the corresponding
spin-independent dark matter scattering cross section, with a view to direct
detection experiments.Comment: 34 pages, 4 figures, additional references adde
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