Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-κB Pathway

10.1371/journal.pone.0048514PLoS ONE712

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Limitação de atividades em idosos: estudo em novos usuários de próteses auditivas por meio do questionário APHAB Activity limitations in the elderly: a study of new hearing aid users using the APHAB questionnaire

OBJETIVO: Avaliar limitações auditivas de idosos com perda auditiva sensorioneural de grau moderado a severo segundo variáveis escolaridade e grau da perda auditiva, por meio do questionário de auto-avaliação Abbreviate Profile of Hearing Aid Benefit (APHAB). MÉTODOS: Foi aplicado o questionário em 30 idosos antes e após três meses de uso da amplificação. A amostra foi composta por 60% mulheres e 40% homens, com média de idade de 71,6 anos. O grau de escolaridade foi distribuído em três categorias: não-alfabetizado, ensino fundamental e ensino médio. Os dados foram analisados estatisticamente. Os escores foram comparados por sub-escala, e a avaliação geral pela subtração desses escores. Além disso, foi calculada a associação entre benefício e grau de escolaridade e grau de perda auditiva. RESULTADOS: O estudo comparativo entre os escores obtidos na aplicação do questionário sem e com prótese auditiva revelou diferença nas sub-escalas Facilidade de Comunicação, Reverberação e Ruído Ambiental, com valores de p<0,001. Na sub-escala Aversão aos Sons ocorreu piora com a amplificação. Houve melhora no desempenho com prótese auditiva na avaliação geral nas três sub-escalas. Não houve associação entre o benefício obtido com a prótese auditiva, grau de escolaridade e grau de perda auditiva. CONCLUSÃO: Há benefício nas sub-escalas: Facilidade de Comunicação, Reverberação e Ruído Ambiental. Não há associação entre benefício, escolaridade e grau da perda auditiva. O benefício obtido na sub-escala Ruído Ambiental é menor que nas sub-escalas Facilidade de Comunicação e Reverberação.<br>PURPOSE: To evaluate hearing limitations among elderly individuals with moderate to severe sensorineural hearing loss according to the variables educational level and degree of hearing loss, using the Abbreviated Profile of Hearing Aid Benefit self-assessment questionnaire. METHODS: The questionnaire was applied to 30 elderly subjects before and after three months of use of amplification. The sample was composed of 60% females and 40% males, with mean age of 71.6 years. Educational level was divided into three categories: illiterate, elementary school, and high school education. Data were analyzed statistically. Scores were compared by subscale and an overall assessment was conducted by subtracting these scores. Moreover, it was calculated the association between benefit and educational level and degree of hearing loss. RESULTS: The comparative study between scores obtained in the questionnaire with and without hearing aid revealed difference in the subscales Ease of Communication, Reverberation and Background Noise, with values p<0.001. In the Aversion to Sounds subscale, it was observed a decline with amplification. Performance improved with the hearing aid in the overall evaluation for all three subscales. There was no association between benefits obtained with the hearing aid, educational level, and degree of hearing loss. CONCLUSION: Benefits were reported in the subscales: Ease of Communication, Reverberation, and Background Noise. No association was found between benefits, educational level and degree of hearing loss. The benefit obtained in the Background Noise subscale is smaller than that observed in Reverberation and Ease of Communication