The final data release of ALLSMOG: a survey of CO in typical local low-M* star-forming galaxies

We present the final data release of the APEX low-redshift legacy survey for molecular gas (ALLSMOG), comprising CO(2-1) emission line observations of 88 nearby, low-mass (10^8.5<M* [M_Sun]<10^10) star-forming galaxies carried out with the 230 GHz APEX-1 receiver on the APEX telescope. The main goal of ALLSMOG is to probe the molecular gas content of more typical and lower stellar mass galaxies than have been studied by previous CO surveys. We also present IRAM 30m observations of the CO(1-0) and CO(2-1) emission lines in nine galaxies aimed at increasing the M*<10^9 M_Sun sample size. In this paper we describe the observations, data reduction and analysis methods and we present the final CO spectra together with archival HI 21cm line observations for the entire sample of 97 galaxies. At the sensitivity limit of ALLSMOG, we register a total CO detection rate of 47%. Galaxies with higher M*, SFR, nebular extinction (A_V), gas-phase metallicity (O/H), and HI gas mass have systematically higher CO detection rates. In particular, the parameter according to which CO detections and non-detections show the strongest statistical differences is the gas-phase metallicity, for any of the five metallicity calibrations examined in this work. We investigate scaling relations between the CO(1-0) line luminosity and galaxy-averaged properties using ALLSMOG and a sub-sample of COLD GASS for a total of 185 sources that probe the local main sequence (MS) of star-forming galaxies and its +-0.3 dex intrinsic scatter from M* = 10^8.5 M_Sun to M* = 10^11 M_Sun. L'_{CO(1-0)} is most strongly correlated with the SFR, but the correlation with M* is closer to linear and almost comparably tight. The relation between L'_{CO(1-0)} and metallicity is the steepest one, although deeper CO observations of galaxies with A_V<0.5 mag may reveal an as much steep correlation with A_V. [abridged

The Antiquity and Evolutionary History of Social Behavior in Bees

A long-standing controversy in bee social evolution concerns whether highly eusocial behavior has evolved once or twice within the corbiculate Apidae. Corbiculate bees include the highly eusocial honey bees and stingless bees, the primitively eusocial bumble bees, and the predominantly solitary or communal orchid bees. Here we use a model-based approach to reconstruct the evolutionary history of eusociality and date the antiquity of eusocial behavior in apid bees, using a recent molecular phylogeny of the Apidae. We conclude that eusociality evolved once in the common ancestor of the corbiculate Apidae, advanced eusociality evolved independently in the honey and stingless bees, and that eusociality was lost in the orchid bees. Fossil-calibrated divergence time estimates reveal that eusociality first evolved at least 87 Mya (78 to 95 Mya) in the corbiculates, much earlier than in other groups of bees with less complex social behavior. These results provide a robust new evolutionary framework for studies of the organization and genetic basis of social behavior in honey bees and their relatives

Accretion of Planetary Material onto Host Stars

Accretion of planetary material onto host stars may occur throughout a star's life. Especially prone to accretion, extrasolar planets in short-period orbits, while relatively rare, constitute a significant fraction of the known population, and these planets are subject to dynamical and atmospheric influences that can drive significant mass loss. Theoretical models frame expectations regarding the rates and extent of this planetary accretion. For instance, tidal interactions between planets and stars may drive complete orbital decay during the main sequence. Many planets that survive their stars' main sequence lifetime will still be engulfed when the host stars become red giant stars. There is some observational evidence supporting these predictions, such as a dearth of close-in planets around fast stellar rotators, which is consistent with tidal spin-up and planet accretion. There remains no clear chemical evidence for pollution of the atmospheres of main sequence or red giant stars by planetary materials, but a wealth of evidence points to active accretion by white dwarfs. In this article, we review the current understanding of accretion of planetary material, from the pre- to the post-main sequence and beyond. The review begins with the astrophysical framework for that process and then considers accretion during various phases of a host star's life, during which the details of accretion vary, and the observational evidence for accretion during these phases.Comment: 18 pages, 5 figures (with some redacted), invited revie

Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum

BACKGROUND: Inflammation has been described as a key pathogenic event in Alzheimer's disease (AD), downstream of amyloid and tau pathology. Preclinical and clinical data suggest that the cholinergic basal forebrain may moderate inflammatory response to different pathologies. OBJECTIVE: To study the association of cholinergic basal forebrain volume and functional connectivity with measures of neuroinflammation in people from the AD spectrum. METHODS: We studied 261 cases from the DELCODE cohort, including people with subjective cognitive decline, mild cognitive impairment, AD dementia, first degree relatives, and healthy controls. Using Bayesian ANCOVA, we tested associations of MRI indices of cholinergic basal forebrain volume and functional connectivity with cerebrospinal fluid (CSF) levels of sTREM2 as a marker of microglia activation, and serum levels of complement C3. Using Bayesian elastic net regression, we determined associations between basal forebrain measures and a large inflammation marker panel from CSF and serum. RESULTS: We found anecdotal to moderate evidence in favor of the absence of an effect of basal forebrain volume and functional connectivity on CSF sTREM2 and serum C3 levels both in Aβ42/ptau-positive and negative cases. Bayesian elastic net regression identified several CSF and serum markers of inflammation that were associated with basal forebrain volume and functional connectivity. The effect sizes were moderate to small. CONCLUSION: Our data-driven analyses generate the hypothesis that cholinergic basal forebrain may be involved in the neuroinflammation response to Aβ42 and phospho-tau pathology in people from the AD spectrum. This hypothesis needs to be tested in independent samples

Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells

Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechanisms in healthy human cells is necessary in order to improve not only patient safety, but also to support future drug development. Since epigenetic regulation directly interacts with genomic and chromosomal packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifications. This review highlights past and current research efforts on the influence of epigenetic modification on genomic stability in healthy human cells

Ostriches Sleep like Platypuses

Mammals and birds engage in two distinct states of sleep, slow wave sleep (SWS) and rapid eye movement (REM) sleep. SWS is characterized by slow, high amplitude brain waves, while REM sleep is characterized by fast, low amplitude waves, known as activation, occurring with rapid eye movements and reduced muscle tone. However, monotremes (platypuses and echidnas), the most basal (or ‘ancient’) group of living mammals, show only a single sleep state that combines elements of SWS and REM sleep, suggesting that these states became temporally segregated in the common ancestor to marsupial and eutherian mammals. Whether sleep in basal birds resembles that of monotremes or other mammals and birds is unknown. Here, we provide the first description of brain activity during sleep in ostriches (Struthio camelus), a member of the most basal group of living birds. We found that the brain activity of sleeping ostriches is unique. Episodes of REM sleep were delineated by rapid eye movements, reduced muscle tone, and head movements, similar to those observed in other birds and mammals engaged in REM sleep; however, during REM sleep in ostriches, forebrain activity would flip between REM sleep-like activation and SWS-like slow waves, the latter reminiscent of sleep in the platypus. Moreover, the amount of REM sleep in ostriches is greater than in any other bird, just as in platypuses, which have more REM sleep than other mammals. These findings reveal a recurring sequence of steps in the evolution of sleep in which SWS and REM sleep arose from a single heterogeneous state that became temporally segregated into two distinct states. This common trajectory suggests that forebrain activation during REM sleep is an evolutionarily new feature, presumably involved in performing new sleep functions not found in more basal animals

Historia de la agroecología en México

A mediados del siglo pasado, existían dos tipos de científicos de la agronomía en México. Unos, que veían una agricultura atrasada y que había, ciegamente, que llevar hacia los avances tec- nológicos más modernos. Otros, que salían al campo y exploraban intensivamente los sistemas indígenas y campesinos. El estudiar y dar a conocer la riqueza tanto biológica como humana que albergaban estos sistemas, dio pie a la agroecología en este país. Sobra decir que varios de los pioneros de esa ciencia a nivel mundial, fueron aprendices de sistemas indígenas mexicanos. En este trabajo se hace el esfuerzo por narrar los hitos históricos más importantes en la investigación y la enseñanza de la agroecología en el pasado y en la actualidad; además, hacemos también una reflexión sobre los desafíos que enfrenta esa disciplina