18 research outputs found
Evaluating how agent methodologies support the specification of the normative environment through the development process
[EN] Due to the increase in collaborative work and the decentralization of processes in
many domains, there is an expanding demand for large-scale, flexible and adaptive software
systems to support the interactions of people and institutions distributed in heterogeneous
environments. Commonly, these software applications should follow specific regulations
meaning the actors using them are bound by rights, duties and restrictions. Since this normative
environment determines the final design of the software system, it should be considered
as an important issue during the design of the system. Some agent-oriented software engineering
methodologies deal with the development of normative systems (systems that have a
normative environment) by integrating the analysis of the normative environment of a system
in the development process. This paper analyses to what extent these methodologies support
the analysis and formalisation of the normative environment and highlights some open issues
of the topic.This work is partially supported by the PROMETEOII/2013/019, TIN2012-36586-C03-01, FP7-29493, TIN2011-27652-C03-00, CSD2007-00022 projects, and the CASES project within the 7th European Community Framework Program under the grant agreement No 294931.Garcia Marques, ME.; Miles, S.; Luck, M.; Giret Boggino, AS. (2014). Evaluating how agent methodologies support the specification of the normative environment through the development process. Autonomous Agents and Multi-Agent Systems. 1-20. https://doi.org/10.1007/s10458-014-9275-zS120Cossentino, M., Hilaire, V., Molesini, A., & Seidita, V. (Eds.). (2014). Handbook on agent-oriented design processes (Vol. VIII, 569 p. 508 illus.). Berlin: Springer.Akbari, O. (2010). A survey of agent-oriented software engineering paradigm: Towards its industrial acceptance. Journal of Computer Engineering Research, 1, 14–28.Argente, E., Botti, V., Carrascosa, C., Giret, A., Julian, V., & Rebollo, M. (2011). 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The natural history of, and risk factors for, progressive Chronic Kidney Disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol
How Does Health Education Given to Lung Cancer Patients Before Thoracotomy Affect Pain, Anxiety, and Respiratory Functions?
Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease
Generation, analysis and functional annotation of expressed sequence tags from the ectoparasitic mite <it>Psoroptes ovis</it>
<p>Abstract</p> <p>Background</p> <p>Sheep scab is caused by <it>Psoroptes ovis </it>and is arguably the most important ectoparasitic disease affecting sheep in the UK. The disease is highly contagious and causes and considerable pruritis and irritation and is therefore a major welfare concern. Current methods of treatment are unsustainable and in order to elucidate novel methods of disease control a more comprehensive understanding of the parasite is required. To date, no full genomic DNA sequence or large scale transcript datasets are available and prior to this study only 484 <it>P. ovis </it>expressed sequence tags (ESTs) were accessible in public databases.</p> <p>Results</p> <p>In order to further expand upon the transcriptomic coverage of <it>P. ovis </it>thus facilitating novel insights into the mite biology we undertook a larger scale EST approach, incorporating newly generated and previously described <it>P. ovis </it>transcript data and representing the largest collection of <it>P. ovis </it>ESTs to date. We sequenced 1,574 ESTs and assembled these along with 484 previously generated <it>P. ovis </it>ESTs, which resulted in the identification of 1,545 unique <it>P. ovis </it>sequences. BLASTX searches identified 961 ESTs with significant hits (E-value < 1E-04) and 584 novel <it>P. ovis </it>ESTs. Gene Ontology (GO) analysis allowed the functional annotation of 880 ESTs and included predictions of signal peptide and transmembrane domains; allowing the identification of potential <it>P. ovis </it>excreted/secreted factors, and mapping of metabolic pathways.</p> <p>Conclusions</p> <p>This dataset currently represents the largest collection of <it>P. ovis </it>ESTs, all of which are publicly available in the GenBank EST database (dbEST) (accession numbers <ext-link ext-link-id="FR748230" ext-link-type="gen">FR748230</ext-link> - <ext-link ext-link-id="FR749648" ext-link-type="gen">FR749648</ext-link>). Functional analysis of this dataset identified important homologues, including house dust mite allergens and tick salivary factors. These findings offer new insights into the underlying biology of <it>P. ovis</it>, facilitating further investigations into mite biology and the identification of novel methods of intervention.</p