Management strategies for systemic lupus erythematosus

The management of systemic lupus erythematosus (SLE) is a challenging task. All interventions to-date are palliative rather than curative as the pathogenesis of the disease remains enigmatic. Treatment-related side effects can be as problematic as the disease itself. The following is a review of the practical management of the disease based on our experience.published_or_final_versio

Outage planning of electrical power system networks using genetic algorithm

An electrical company is responsible for the maintenance of a transmission network of high voltage electricity. The maintenance schedule must be planned so as to minimize outage costs, taking into consideration various factors such as system security/reliability, system availability, and manpower utilization. With the rapid growth of organization, planning engineers are required to fulfill additional roles in order to increase productivity. To this end, a fast response and accurate mechanism is required to assist the planning engineers in dealing with the daily operation. This paper describes how a proposed maintenance schedule can be obtained automatically by the adoption of genetic algorithm. The main aim is to determine the maintenance schedule of circuit outage with minimizing the maintenance cost and maximizing the circuit availability under certain unavoidable system constraints. Further, an additional search mechanism called "final tuning search" is developed to enhance the system performance.published_or_final_versio

Neuropsychiatric manifestations in southern Chinese patients with systemic lupus erythematosus (SLE) according to the 1999 ACR nomenclature and their clinical associations

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Talaromyces marneffei genomic, transcriptomic, proteomic and metabolomic studies reveal mechanisms for environmental adaptations and virulence

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Time-dependent trapping of pollinators driven by the alignment of floral phenology with insect circadian rhythms

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Late-onset systemic lupus erythematosus (SLE) in southern Chinese

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Polyketides, Toxins and Pigments in Penicillium marneffei

Penicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence of P. marneffei infection as an important AIDS-defining condition. Recently, we published the genome sequence of P. marneffei. In the P. marneffei genome, 23 polyketide synthase genes and two polyketide synthase-non-ribosomal peptide synthase hybrid genes were identified. This number is much higher than those of Coccidioides immitis and Histoplasma capsulatum, important pathogenic thermally dimorphic fungi in the Western world. Phylogenetically, these polyketide synthase genes were distributed evenly with their counterparts found in Aspergillus species and other fungi, suggesting that polyketide synthases in P. marneffei did not diverge from lineage-specific gene duplication through a recent expansion. Gene knockdown experiments and ultra-high performance liquid chromatography-photodiode array detector/electrospray ionization-quadruple time of flight-mass spectrometry analysis confirmed that at least four of the polyketide synthase genes were involved in the biosynthesis of various pigments in P. marneffei, including melanin, mitorubrinic acid, mitorubrinol, monascorubrin, rubropunctatin, citrinin and ankaflavin, some of which were mycotoxins and virulence factors of the fungus.published_or_final_versio

Phase-Tunable Calcium Phosphate Biomaterials Synthesis and Application in Protein Delivery

Calcium phosphates (CaP) are important biomaterials used in tissue engineering and drug delivery, due to their biocompatibility, low toxicity, and osteoconductivity. However, controlling the phase of CaP, especially tricalcium phosphate (TCP), is very challenging under mild conditions, particularly when using one preparation protocol for all CaP phases. It is also crucial to produce these biomaterials economically and reproducibly. Herein, three of the most commonly employed CaP, including beta-tricalcium phosphate (β-TCP), dicalcium phosphate anhydrous (DCPA), and hydroxyapatite (HA) were, for the first time, successfully synthesized by altering the reaction solvent, using calcium acetate monohydrate as a precursor and a rapid microwave-assisted synthetic method. A variety of CaP particle morphologies were obtained, including elliptical and plate-shaped with different porosities. Compared with conventional heating, CaP biomaterials synthesized using microwave heating showed greater reproducibility, higher yields, and shorter reaction time. By varying the reaction solvents, morphologies and phases of CaP were controlled, leading to an enhanced protein bovine serum albumin (BSA) loading, with a higher BSA absorption observed according to the trend DCPA> β-TCP > HA. Furthermore, the phase, specific surface area, and pore size were shown to play decisive roles in protein desorption with a higher release amount observed according to the trend DCPA > β-TCP > HA. Finally, it is found that larger pores are also beneficial to BSA adsorption

Reproductive resource partitioning in two sympatric Goniothalamus species (Annonaceae) from Borneo: floral biology, pollinator trapping and plant breeding system

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Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of <i>Talaromyces</i> (<i>Penicillium</i>) <i>marneffei</i>

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