514 research outputs found
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Regulation of metabolism by miR-378
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression. The present invention also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-378 and/or miR-378* expression or activity. Methods of treating or preventing pathologic cardiac hypertrophy, cardiac remodeling, myocardial infarction, or heart failure in a subject by inhibiting the expression or activity of miR-378 and/or miR-378* in a subject are also disclosed.Board of Regents, University of Texas Syste
Charm quenching in heavy-ion collisions at the LHC
D-meson suppression in Pb-Pb collisions at the LHC due to charm quark
in-medium energy loss is estimated within a model that describes the available
quenching measurements at RHIC. The result is compared to that previously
published by the author. The expected sensitivity of the ALICE experiment for
studying charm energy loss via fully-reconstructed D^0-meson decays is also
presented.Comment: 8 pages, 3 figures. To appear in the proceedings of Hot Quarks 2004:
Workshop for Young Scientists on the Physics of Ultrarelativistic
Nucleus-Nucleus Collisions, Taos Valley, New Mexico, 18-24 July 2004.
Submitted to J. Phys.
ALICE potential for heavy-flavour physics
The Large Hadron Collider (LHC), where lead nuclei will collide at the
unprecedented c.m.s. energy of 5.5 TeV per nucleon-nucleon pair, will offer new
and unique opportunities for the study of the properties of strongly
interacting matter at high energy density over extended volumes. We will
briefly explain why heavy-flavour particles are well-suited tools for such a
study and we will describe how the ALICE experiment is preparing to make use of
these tools.Comment: 6 pages, 3 figures, prepared for the Proceedings of "Strange Quark
Matter 2007", Levoca, Slovaki
Charm and beauty of the Large Hadron Collider
With the acceleration of lead nuclei in the LHC, heavy-ion physics will enter
a new energy domain. One of the main novelties introduced by the 30-fold
energy-jump from RHIC to the LHC is the abundant heavy-quark production. After
discussing a few examples of physics issues that can be addressed using heavy
quarks, we present a selection of results on the expected experimental
capability of ALICE, the dedicated heavy-ion experiment at the LHC, in the
open-heavy-flavour sector.Comment: 10 pages, 5 figures. Invited talk at Strangeness in Quark Matter
(SQM) 2004, Cape Town, South Africa, 15-20 September 2004. Submitted to J.
Phys.
Measuring beauty production in Pb-Pb collisions at the LHC via single electrons in ALICE
We present the expected ALICE performance for the measurement of the
p_t-differential cross section of electrons from beauty decays in central Pb-Pb
collisions at the LHC.Comment: 4 pages, 2 figures, proceeding of poster presentation at "Quark
Matter 2005
Kaon and production vs Participants in Nuclear Collisions
Data on kaon and production in nuclear collisions as a function of
centrality are analysed both at AGS and SPS energy range. We compare the
results of several experiments, looking for common trend in `participant
scaling' of production yields. We find a smooth description of scaled kaon and
yields as a function of participant density. We also show a participant
density dependence of kaons and produced in the forward hemisphere for
proton-nucleus collisions.Comment: Proceedings of the International Conference on Strangeness in Quark
Matter, 20-25 July 2000, Berkeley, CA. To appear in Journal of Physics G:
Nuclear and Particle Physic
Correlations of Heavy Quarks Produced at Large Hadron Collider
We study the correlations of heavy quarks produced in relativistic heavy ion
collisions and find them to be quite sensitive to the effects of the medium and
the production mechanisms. In order to put this on a quantitative footing, as a
first step, we analyze the azimuthal, transverse momentum, and rapidity
correlations of heavy quark-anti quark () pairs in
collisions at (). This sets the stage for the
identification and study of medium modification of similar correlations in
relativistic collision of heavy nuclei at the Large Hadron Collider. Next we
study the additional production of charm quarks in heavy ion collisions due to
multiple scatterings, {\it viz.}, jet-jet collisions, jet-thermal collisions,
and thermal interactions. We find that these give rise to azimuthal
correlations which are quite different from those arising from prompt initial
production at leading order and at next to leading order.Comment: 26 pages, 15 figures. Three new figures added, comparison to
experimental data included, abstract and discussion expande
A Comment on Conical Flow Induced by Heavy-Quark Jets
The suppression of high transverse momentum particles, recently discovered at
RHIC, is commonly interpreted as due to parton energy loss. In high energy
nuclear collisions, QCD jets would deposit a large fraction of their energy and
into the produced matter. The question of how this energy is degraded and
whether we can use this phenomenon to probe the properties of the produced
matter is now under active discussion. It has been proposed that if this
matter, which is now being referred to as a {\em strongly coupled Quark-Gluon
Plasma} (sQGP), may behave as a liquid with a very small viscosity.
In this case, a very specific collective excitation should be produced,
called the ``conical flow'', similar e.g. to the sonic booms generated by the
shock waves produced by supersonic planes. The RHIC experiments seem indeed to
be obtaining some indication that the production of particles emitted opposite
to a high- jet may actually be peaked away from the quenched jet
direction, at an angle roughly consistent with the direction expected in case a
shock wave is produced (i.e. orthogonal to the Mach cone). In this note we
speculate that for tagged heavy-quark jets one may observe a shrinkage of the
Mach cone at moderate . The experimental observation of such an effect
would be a very good test for the validity of the whole picture currently
emerging from the study of partonic matter in nuclear collisions
Hard probes in heavy ion collisions at the LHC: heavy flavour physics
We present the results from the heavy quarks and quarkonia working group.
This report gives benchmark heavy quark and quarkonium cross sections for
and collisions at the LHC against which the rates can be compared in
the study of the quark-gluon plasma. We also provide an assessment of the
theoretical uncertainties in these benchmarks. We then discuss some of the cold
matter effects on quarkonia production, including nuclear absorption,
scattering by produced hadrons, and energy loss in the medium. Hot matter
effects that could reduce the observed quarkonium rates such as color screening
and thermal activation are then discussed. Possible quarkonium enhancement
through coalescence of uncorrelated heavy quarks and antiquarks is also
described. Finally, we discuss the capabilities of the LHC detectors to measure
heavy quarks and quarkonia as well as the Monte Carlo generators used in the
data analysis.Comment: 126 pages Latex; 96 figures included. Subgroup report, to appear in
the CERN Yellow Book of the workshop: Hard Probes in Heavy Ion Collisions at
the LHC. See also http://a.home.cern.ch/f/frixione/www/hvq.html for a version
with better quality for a few plot
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