The Trispectrum in the Multi-brid Inflation

The trispectrum is at least as important as the bispectrum and its size can be characterized by two parameters $\tau_{NL}$ and $g_{NL}$. In this short paper, we focus on the Multi-brid inflation, in particular the two-brid inflation model in arXiv.0805.0974, and find that $\tau_{NL}$ is always positive and roughly equals to $({6\over 5}f_{NL})^2$ for the low scale inflation, but $g_{NL}$ can be negative or positive and its order of magnitude can be the same as that of $\tau_{NL}$ or even largerComment: 12 pages; minor correction, refs added; further refs added, version for publication in JCA

A geometric description of the non-Gaussianity generated at the end of multi-field inflation

In this paper we mainly focus on the curvature perturbation generated at the end of multi-field inflation, such as the multi-brid inflation. Since the curvature perturbation is produced on the super-horizon scale, the bispectrum and trispectrum have a local shape. The size of bispectrum is measured by $f_{NL}$ and the trispectrum is characterized by two parameters $\tau_{NL}$ and $g_{NL}$. For simplicity, the trajectory of inflaton is assumed to be a straight line in the field space and then the entropic perturbations do not contribute to the curvature perturbation during inflation. As long as the background inflaton path is not orthogonal to the hyper-surface for inflation to end, the entropic perturbation can make a contribution to the curvature perturbation at the end of inflation and a large local-type non-Gaussiantiy is expected. An interesting thing is that the non-Gaussianity parameters are completely determined by the geometric properties of the hyper-surface of the end of inflation. For example, $f_{NL}$ is proportional to the curvature of the curve on this hyper-surface along the adiabatic direction and $g_{NL}$ is related to the change of the curvature radius per unit arc-length of this curve. Both $f_{NL}$ and $g_{NL}$ can be positive or negative respectively, but $\tau_{NL}$ must be positive and not less than $({6\over 5}f_{NL})^2$.Comment: 19 pages, 4 figures; refs added; a correction to \tau_{NL} for n-field inflation added, version accepted for publication in JCA

Lectures on inflation and cosmological perturbations

The purpose of these lectures is to give a pedagogical introduction to inflation and the production of primordial perturbations, as well as a review of some of the latest developments in this domain. After a short introduction, we review the main principles of the Hot Big Bang model, as well as its limitations. This motivates the study of cosmological inflation induced by a slow-rolling scalar field. We then turn to the analysis of cosmological perturbations, and explain how the vacuum quantum fluctuations are amplified during an inflationary phase. The next step consists in relating the perturbations generated during inflation to the perturbations of the cosmological fluid in the radiation dominated phase. The final part of these lectures gives a review of more general models of inflation, involving multiple fields or non standard kinetic terms. Although more complicated, these models are usually motivated by high energy physics and they can lead to specific signatures that are not expected in the simplest models of inflation. After introducing a very general formalism to describe perturbations in multi-field models with arbitrary kinetic terms, several interesting cases are presented. We also stress the role of entropy perturbations in the context of multi-field models. Finally, we discuss in detail the non-Gaussianities of the primordial perturbations and some models that could produce a detectable level of non-Gaussianities.Comment: 56 pages, 5 figures; Lectures given at the Second TRR33 Winter School on cosmology, Passo del Tonale (Italy), December 200

DPPI May Activate KLK4 during Enamel Formation

Kallikrein-4 (KLK4) is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. KLK4 is secreted as an inactive zymogen (pro-KLK4), and identification of its activator remains elusive. Dipeptidyl peptidase I (DPPI) is a cysteine aminopeptidase that can activate several serine proteases. In this study, we sought to examine DPPI expression in mouse enamel organ and determine if DPPI could activate KLK4. Real-time PCR showed DPPI expression throughout amelogenesis, with highest expression at maturation, and immunohistochemical staining of mouse incisors confirmed DPPI expression by ameloblasts. We demonstrate in vitro that DPPI activates pro-KLK4 to cleave a fluorogenic peptide containing a KLK4 cleavage site. Examination of mature enamel from DPPI null mice by FTIR showed no significant accumulation of protein; however, microhardness testing revealed that loss of DPPI expression significantly reduced enamel hardness