Fecal Viral Concentration and Diarrhea in Norovirus Gastroenteritis

Fecal viral concentrations of 40 patients infected with norovirus genogroup GII.4 correlated with diarrhea duration and frequency of vomiting. Higher viral concentration and older age were independently associated with prolonged diarrhea (>4 days). These findings provide information on the pathogenesis and transmission of norovirus infections

Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors

10.1016/j.diabres.2007.12.003Diabetes Research and Clinical Practice802224-23

Influenza virus load in hospitalised patients.

1. Hospitalised patients with severe influenza have persistently high viral loads, for whom a different therapeutic approach may be needed. 2. Active screening of influenza infection should be performed in all high-risk patients hospitalised with febrile respiratory illness. Early diagnosis and treatment to suppress the high viral load may maximise clinical benefit. 3. For late presenting high- risk patients with severe symptoms, their viral load may remain high, and initiation of antiviral treatment may still be worthwhile. 4. More stringent infection control measures, including strict droplet precautions and preferably isolation for an extended period of time may be necessary owing to prolonged viral shedding. 5. Randomised, controlled trials are indicated to address timing and dosage of treatment for severe influenza infectio

Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years

Diabetic Medicine2191007-1013DIME