10.1016/j.diabres.2007.12.003Diabetes Research and Clinical Practice802224-23

Cockram, C.S.

Khalid, B.A.K.

Mohan, V.

Pan, C.Y.

Thai, A.C.

Yeo, J.P.

Zimmet, P.

In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell

function and cardio-metabolic risk factors in young-onset Asian diabetic patients are

evaluated at baseline. The study population consisted of 912 patients (from China, India,

Malaysia and Singapore) with age 12–40 years and diabetes duration <12 months. Autoantibodies

to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta

cell function and cardio-metabolic risk parameters were assessed. Among our young patient

cohort, 105 (11.5%) patients wereGADA and/or IA-2A positives (Ab +ve). Ab +ve patients were

younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency

of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to

Ab ve patients (54%). However, a substantial proportion of patients in both groups of

patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In

our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet

autoimmunity. At least 60% of Ab +ve and 50% of Ab ve patients demonstrated classical

features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the

cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and

albuminuria were common in our patients with young-onset diabetes

Thai, A

Mohan, V

Khalid, B

Cockram, C

Pan, C

Zimmet, P

Yeo, J

Eprints @MDRF

Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors

In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12-40 years and diabetes duration &lt;12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab -ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab -ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes

Thai, A. C.

Khalid, B. A. K.

Cockram, C.  S.

Pan, C. Y.

Yeo, J.  P.

Indian Academy of Sciences

Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): association with clinical characteristics, beta cell function and cardio-metabolic risk factors

In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12-40 years and diabetes duration &lt;12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab -ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab -ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes

Publications of the IAS Fellows

ScholarBank@NUS

Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors

Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors

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Eprints @MDRF

Indian Academy of Sciences

Publications of the IAS Fellows

ScholarBank@NUS