Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine

AbstractDiethanolamine (DEA) has been found to produce liver and kidney tumors in mice following lifetime dermal exposures. Data regarding the mode of action by which DEA produces these tumors were used to support a dose-response assessment that resulted in a no-significant-risk-level (NSRL) for dermal exposures to DEA. DEA and its metabolites are structural analogs to endogenous agents important to choline homeostasis. Sufficient information is available to support an epigenetic MOA involving the perturbation of choline homeostasis and hepatic methylation reactions in the formation of mouse liver tumors. This MOA may also apply to mouse kidney tumors, but direct measurements for key events in kidney are lacking. For both tumor types, dose-response data were pooled across four cancer bioassays conducted for DEA and DEA-containing condensates in order to provide a more robust characterization of the dose-response relationships. Doses were expressed in terms of dermally absorbed dose so that the dose-dependency and species differences in the dermal absorption of DEA were addressed. The resulting NSRL value of 3400 ug/day for dermal exposures to DEA is considered to be protective of human health for both tumor endpoints

Solar sail capture trajectories at Mercury

Mercury is an ideal environment for future planetary exploration by solar sail since it has proved difficult to reach with conventional propulsion and hence remains largely unexplored. In addition, its proximity to the Sun provides a solar sail acceleration of order ten times the sail characteristic acceleration at 1 AU. Conventional capture techniques are shown to be unsuitable for solar sails and a new method is presented. It is shown that capture is bound by upper and lower limits on the orbital elements of the approach orbit and that failure to be within limits results in a catastrophic collision with the planet. These limits are presented for a range of capture inclinations and sail characteristic accelerations. It is found that sail hyperbolic excess velocity is a critical parameter during capture at Mercury, with only a narrow allowed band in order to avoid collision with the planet. The new capture methodis demonstrated for a Mercury sample return mission

The development of linked databases and environmental modelling systems for decision-making in London

A basic requirement for a city's growth is the availability of land, raw material and water. For continued and sustainable development of today’s cities we must be able to meet these basic requirements whilst being mindful of the environment and its relationship with anthropogenic activity. The heterogeneous and complex nature of urban systems where there are obvious environmental and anthropogenic inter-dependencies necessitates a more holistic approach to decision-making. New developments such as linked databases of environmental data and integrated environmental modelling systems provide new ways of organising cross-disciplinary information and a means to apply this to explain, explore and predict the urban systems response to environmental change. In this paper we show how, accessibility to linked databases, detailed understanding of the geology and integrated environmental modelling solutions has the potential to provide decision-makers and policy developers with the science based information needed to understand and address these challenges

A probabilistic risk-based decision framework for structural health monitoring

Obtaining the ability to make informed decisions regarding the operation and maintenance of structures, provides a major incentive for the implementation of structural health monitoring (SHM) systems. Probabilistic risk assessment (PRA) is an established methodology that allows engineers to make risk-informed decisions regarding the design and operation of safety-critical and high-value assets in industries such as nuclear and aerospace. The current paper aims to formulate a risk-based decision framework for structural health monitoring that combines elements of PRA with the existing SHM paradigm. As an apt tool for reasoning and decision-making under uncertainty, probabilistic graphical models serve as the foundation of the framework. The framework involves modelling failure modes of structures as Bayesian network representations of fault trees and then assigning costs or utilities to the failure events. The fault trees allow for information to pass from probabilistic classifiers to influence diagram representations of decision processes whilst also providing nodes within the graphical model that may be queried to obtain marginal probability distributions over local damage states within a structure. Optimal courses of action for structures are selected by determining the strategies that maximise expected utility. The risk-based framework is demonstrated on a realistic truss-like structure and supported by experimental data. Finally, a discussion of the risk-based approach is made and further challenges pertaining to decision-making processes in the context of SHM are identified

Upper Pleistocene Stratigraphy, Paleoecology, and Archaeology of the Northern Yukon Interior, Eastern Beringia. I. Bonnet Plume Basin

New stratigraphic and chronometric data show that Bonnet Plume Basin, in northeastern Yukon Territory, was glaciated in late Wisconsinan time rather than during an earlier advance of Laurentide ice. This conclusion has important ramifications not only for the interpretation of all-time glacial limits farther north along the Richardson Mountains but also for non-glaciated basins in the Porcupine drainage to the northwest. The late Wisconsinan glacial episode in Bonnet Plume Basin is here named the Hungry Creek advance after the principal Quaternary section in the basin. Sediments beneath the till at Hungry Creek have produced well-produced pollen, plant macrofossils, insects, and a few vertebrate remains. The plant and invertebrate fossils provide a detailed, if temporally restricted, record of a portion of the mid-Wisconsinan interstadial, while the vertebrate fossils include the oldest Yukon specimen of the Yukon wild ass. Some of the mid-Wisconsinan sediments have also yielded distinctive chert flakes that represent either a previously unreported product of natural fracturing or a by-product of stone tool manufacture by human residents of Bonnet Plume Basin. In addition to presenting new data on these diverse but interrelated topics, this paper serves as an introduction to a series of reports that will treat in turn the Upper Pleistocene record of Bluefish, Old Crow, and Bell basins, respectively.&nbsp

Scaling of Aharonov-Bohm couplings and the dynamical vacuum in gauge theories

Recent results on the vacuum polarization induced by a thin string of magnetic flux lead us to suggest an analogue of the Copenhagen `flux spaghetti' QCD vacuum as a possible mechanism for avoiding the divergence of perturbative QED, thus permitting consistent completion of the full, nonperturbative theory. The mechanism appears to operate for spinor, but not scalar, QED.Comment: 11 pages, ITP-SB-92-40, (major conceptual evolution from original

The ecology of immune state in a wild mammal, Mus musculus domesticus

The immune state of wild animals is largely unknown. Knowing this and what affects it is important in understanding how infection and disease affects wild animals. The immune state of wild animals is also important in understanding the biology of their pathogens, which is directly relevant to explaining pathogen spillover among species, including to humans. The paucity of knowledge about wild animals' immune state is in stark contrast to our exquisitely detailed understanding of the immunobiology of laboratory animals. Making an immune response is costly, and many factors (such as age, sex, infection status, and body condition) have individually been shown to constrain or promote immune responses. But, whether or not these factors affect immune responses and immune state in wild animals, their relative importance, and how they interact (or do not) are unknown. Here, we have investigated the immune ecology of wild house mice—the same species as the laboratory mouse—as an example of a wild mammal, characterising their adaptive humoral, adaptive cellular, and innate immune state. Firstly, we show how immune variation is structured among mouse populations, finding that there can be extensive immune discordance among neighbouring populations. Secondly, we identify the principal factors that underlie the immunological differences among mice, showing that body condition promotes and age constrains individuals’ immune state, while factors such as microparasite infection and season are comparatively unimportant. By applying a multifactorial analysis to an immune system-wide analysis, our results bring a new and unified understanding of the immunobiology of a wild mammal