Exploring Lay Uncertainty about an Environmental Health Risk

How do laypeople perceive uncertainties about environmental health risks? How do risk-related cognitions and emotions influence these uncertainties, and what roles do sociodemographic and contextual factors, risk judgments, and information exposures play? This study explores these questions using secondary analyses of survey data. Results suggest that uncertainty reflects individual-level emotions and cognitions, but may also be shaped by a variety of social and contextual factors. Emotions (worry and anger) are strongly associated with perceived uncertainty, and perceived lack of knowledge and perceived likelihood of becoming ill are weakly associated with it. Several demographic variables, information exposures, and risk judgment variables affect perceived uncertainty indirectly, primarily through perceived knowledge and emotions. These findings raise a variety of questions about the complex and dynamic interactions among risk contexts, socioeconomic factors, communication processes, perceived knowledge, emotions, and perceived uncertainties about risks

Sober on the holiday: is it un-Australian?

Tourism media research is focusing on the nexus where two areas meet; either where tourism is impacted upon by media, or where the media is affected by tourism practices and industries. This paper will primarily be situated in the first of these categories by examining travelogues in women\u27s magazines, in this case Marie Claire, and ask what influences the content of these can have on the consumers of the media. It could be argued that travelogues in actual fact would be part of the second category – simply subjective descriptions of actual tourist experiences. This paper will, however, suggest that the influence is to some degree mutual, and whereas the portrayals in travelogues do inform us about some experiences, they might simultaneously form a social tableau that readers are unconsciously emulating in their own behaviour. The extrinsic and intrinsic messages incorporated in travelogues will be examined here using qualitative content analysis and discourse analysis. The discussion of tourism and media influence will be related to debates regarding myths surrounding national identity construction, alcohol consumption, and Australianness. This paper rejects some of those constructs and raises further questions about the role media plays in naturalizing the link between alcohol and leisure, and about how Australian women might be shaping their beliefs, their identities, and their behaviour based on the media messages they are consuming

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

Many clinical trials have evaluated the benefit of long-term use of antiplatelet drugs in reducing the risk of clinical thrombotic events. Aspirin and ticlopidine have been shown to be effective, but both have potentially serious adverse effects. Clopidogrel, a new thienopyridine derivative similar to ticlopidine, is an inhibitor of platelet aggregation induced by adenosine diphosphate. METHODS: CAPRIE was a randomised, blinded, international trial designed to assess the relative efficacy of clopidogrel (75 mg once daily) and aspirin (325 mg once daily) in reducing the risk of a composite outcome cluster of ischaemic stroke, myocardial infarction, or vascular death; their relative safety was also assessed. The population studied comprised subgroups of patients with atherosclerotic vascular disease manifested as either recent ischaemic stroke, recent myocardial infarction, or symptomatic peripheral arterial disease. Patients were followed for 1 to 3 years. FINDINGS: 19,185 patients, with more than 6300 in each of the clinical subgroups, were recruited over 3 years, with a mean follow-up of 1.91 years. There were 1960 first events included in the outcome cluster on which an intention-to-treat analysis showed that patients treated with clopidogrel had an annual 5.32% risk of ischaemic stroke, myocardial infarction, or vascular death compared with 5.83% with aspirin. These rates reflect a statistically significant (p = 0.043) relative-risk reduction of 8.7% in favour of clopidogrel (95% Cl 0.3-16.5). Corresponding on-treatment analysis yielded a relative-risk reduction of 9.4%. There were no major differences in terms of safety. Reported adverse experiences in the clopidogrel and aspirin groups judged to be severe included rash (0.26% vs 0.10%), diarrhoea (0.23% vs 0.11%), upper gastrointestinal discomfort (0.97% vs 1.22%), intracranial haemorrhage (0.33% vs 0.47%), and gastrointestinal haemorrhage (0.52% vs 0.72%), respectively. There were ten (0.10%) patients in the clopidogrel group with significant reductions in neutrophils (< 1.2 x 10(9)/L) and 16 (0.17%) in the aspirin group. INTERPRETATION: Long-term administration of clopidogrel to patients with atherosclerotic vascular disease is more effective than aspirin in reducing the combined risk of ischaemic stroke, myocardial infarction, or vascular death. The overall safety profile of clopidogrel is at least as good as that of medium-dose aspirin