Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases

Ethnoveterinary Uses Of Medicinal Plants Among Traditional Herbal Healers In Alaknanda Catchment Of Uttarakhand, India

The people of far-flung rural areas still depend to a large extent upon plants and household remedies for curing veterinary ailments. The folk knowledge of ethnoveterinary medicine and its significance has been identified by the traditional communities through a process of experience over hundreds of years. The paper deals with 34 ailments commonly found in nine different categories of livestock/animals (i e. buffalo, cow, oxen, sheep, goat, horse, mule, dog and cat) and their treatment with 73 medicinal plant species belonging to 70 genera and 45 families that occur in forests as well as close vicinity of the rural settlements. Out of the total population, majority of the people (more than 80%) was found dependent on traditional (herbal) system of treatments practiced by local herbal healers (Pashu Vaidyas), while rest of the people preferred modern (allopathic) system of treatments for curing veterinary ailments. In this study we observed that old aged people have more knowledge and experience particularly in remote areas for curing veterinary ailments. The traditional system of treatment is one of the most important prevailing systems in the area where modern veterinary health care facilities are rare or in very poor conditions

Ethnobotanical Uses of Plants among the Bhotiya Tribal Communities of Niti Valley in Central Himalaya, India

researchA study of the medicinal plants and knowledge of diseases was conducted in Bhotiya tribal communities in the Niti valley of Alaknanda catchment in Central Himalaya. Indigenous knowledge of local traditional healers about plants used for medicinal purposes was collected through questionnaire and interviews. Eighty-six plant species were identified as being used for treatment of 37 common ailments. The methods and application of uses of these plants varies and was based on the nature of disease