Altered CD38 expression in thioacetamide-induced rat model of liver cirrhosis

Master'sMASTER OF SCIENC

Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection

SummaryAlthough type I interferon (IFN-I) is thought to be beneficial against microbial infections, persistent viral infections are characterized by high interferon signatures suggesting that IFN-I signaling may promote disease pathogenesis. During persistent lymphocytic choriomeningitis virus (LCMV) infection, IFNα and IFNβ are highly induced early after infection, and blocking IFN-I receptor (IFNAR) signaling promotes virus clearance. We assessed the specific roles of IFNβ versus IFNα in controlling LCMV infection. While blockade of IFNβ alone does not alter early viral dissemination, it is important in determining lymphoid structure, lymphocyte migration, and anti-viral T cell responses that lead to accelerated virus clearance, approximating what occurs during attenuation of IFNAR signaling. Comparatively, blockade of IFNα was not associated with improved viral control, but with early dissemination of virus. Thus, despite their use of the same receptor, IFNβ and IFNα have unique and distinguishable biologic functions, with IFNβ being mainly responsible for promoting viral persistence

Experimental validation of the recovery effect in batteries for wearable sensors and healthcare devices discovering the existence of hidden time constants

Wearable sensors and healthcare devices use small lightweight batteries to power their typical operations of monitoring and tracking. It becomes absolutely vital to effectively utilise all the available battery charge for device longevity between charges. The electrochemical recovery effect enables the extraction of more power from the battery when implementing idle times in between use cycles, and has been used to develop various power management techniques. However, there is no evidence concerning the actual increase in available power that can be attained using the recovery effect. Also, this property cannot be generalised on all the battery chemistries since it is an innate phenomenon, relying on the anode/cathode material. Indeed recent developments suggest that recovery effect does not exist at all. This paper presents experimental results to verify the presence and level of the recovery effect in commonly used battery chemistries in wearable sensors and healthcare devices. The results have revealed that the recovery effect significantly does exist in certain batteries, and importantly we show that it is also comprised of two different time constants. This novel finding has important implications for the development of power management techniques that utilise the recovery effect with application in a large range of battery devices

Tea drinking and cognitive function in oldest-old Chinese

10.1007/s12603-012-0077-1The Journal of Nutrition, Health & Aging169754-75

Analytic theory of ground-state properties of a three-dimensional electron gas at varying spin polarization

We present an analytic theory of the spin-resolved pair distribution functions $g_{\sigma\sigma'}(r)$ and the ground-state energy of an electron gas with an arbitrary degree of spin polarization. We first use the Hohenberg-Kohn variational principle and the von Weizs\"{a}cker-Herring ideal kinetic energy functional to derive a zero-energy scattering Schr\"{o}dinger equation for $\sqrt{g_{\sigma\sigma'}(r)}$. The solution of this equation is implemented within a Fermi-hypernetted-chain approximation which embodies the Hartree-Fock limit and is shown to satisfy an important set of sum rules. We present numerical results for the ground-state energy at selected values of the spin polarization and for $g_{\sigma\sigma'}(r)$ in both a paramagnetic and a fully spin-polarized electron gas, in comparison with the available data from Quantum Monte Carlo studies over a wide range of electron density.Comment: 13 pages, 8 figures, submitted to Phys. Rev.

Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths

We review observations of several classes of neutron-star-powered outflows: pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe interacting directly with interstellar medium (ISM), and magnetar-powered outflows. We describe radio, X-ray, and gamma-ray observations of PWNe, focusing first on integrated spectral-energy distributions (SEDs) and global spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering array of morphologies, with jets, trails, and other structures. Several of the 23 so far identified magnetars show evidence for continuous or sporadic emission of material, sometimes associated with giant flares, and a few possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts and Blazars: Physics of Extreme Energy Release

Nucleonic gamma-ray production in Pulsar Wind Nebulae

Observations of the inner radian of the Galactic disk at very high energy (VHE) gamma-rays have revealed at least 16 new sources. Besides shell type super-nova remnants, pulsar wind nebulae (PWN) appear to be a dominant source population in the catalogue of VHE gamma-ray sources. Except for the Crab nebula, the newly discovered PWN are resolved at VHE gamma-rays to be spatially extended (5-20 pc). Currently, at least 3 middle aged ($t>10$ kyrs) PWN (Vela X, G18.0-0.7, and G313.3+0.6 in the ``Kookaburra'' region) and 1 young PWN MSH 15-5{\it2} ($t=1.55$ kyrs) have been identified to be VHE emitting PWN (sometimes called ``TeV Plerions''). Two more candidate ``TeV Plerions'' have been identifed and have been reported at this conference [1]. In this contribution, the gamma-ray emission from Vela X is explained by a nucleonic component in the pulsar wind. The measured broad band spectral energy distribution is compared with the expected X-ray emission from primary and secondary electrons. The observed X-ray emission and TeV emission from the three middle aged PWN are compared with each other.Comment: 6 pages, 3 figures, to appear in proceedings "The Multi-Messenger Approach to High-Energy Gamma-Ray Sources", Barcelona July 200

Sexual violence against women and children in Chinese societies

This article provides a comprehensive overview of the reported patterns of sexual violence against women and children in China. It reviews the prevalence of and risk factors for various types of sexual violence and discusses community knowledge and perceptions of these violent acts. It also critically examines three major problems of sexual violence research in China. First, the diversity of findings and study methods reported by surveys and criminal reports reflects the problems in obtaining accurate figures on the scope of the problem. Second, precautions must be taken in reading studies on Chinese culture-specific risk factors for domestic violence. Third, the study of culture-specific factors should not focus solely on cultural factors in a vacuum but rather, should examine traditional culture in the context of modern societies and consensus international standards of human rights. Recommendations for future research are also discussed. © 2009 Sage Publications.postprin

Magnetic fields in supernova remnants and pulsar-wind nebulae

We review the observations of supernova remnants (SNRs) and pulsar-wind nebulae (PWNe) that give information on the strength and orientation of magnetic fields. Radio polarimetry gives the degree of order of magnetic fields, and the orientation of the ordered component. Many young shell supernova remnants show evidence for synchrotron X-ray emission. The spatial analysis of this emission suggests that magnetic fields are amplified by one to two orders of magnitude in strong shocks. Detection of several remnants in TeV gamma rays implies a lower limit on the magnetic-field strength (or a measurement, if the emission process is inverse-Compton upscattering of cosmic microwave background photons). Upper limits to GeV emission similarly provide lower limits on magnetic-field strengths. In the historical shell remnants, lower limits on B range from 25 to 1000 microGauss. Two remnants show variability of synchrotron X-ray emission with a timescale of years. If this timescale is the electron-acceleration or radiative loss timescale, magnetic fields of order 1 mG are also implied. In pulsar-wind nebulae, equipartition arguments and dynamical modeling can be used to infer magnetic-field strengths anywhere from about 5 microGauss to 1 mG. Polarized fractions are considerably higher than in SNRs, ranging to 50 or 60% in some cases; magnetic-field geometries often suggest a toroidal structure around the pulsar, but this is not universal. Viewing-angle effects undoubtedly play a role. MHD models of radio emission in shell SNRs show that different orientations of upstream magnetic field, and different assumptions about electron acceleration, predict different radio morphology. In the remnant of SN 1006, such comparisons imply a magnetic-field orientation connecting the bright limbs, with a non-negligible gradient of its strength across the remnant.Comment: 20 pages, 24 figures; to be published in SpSciRev. Minor wording change in Abstrac