Powder Bed Layer Characteristics: The Overseen First-Order Process Input

A discrete element powder model is used in conjunction with a finite volume melting model on the first layer of a powder bed selective laser melting process

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder

GRILL: a code to calculate the spectrum of lower-hybrid waves launched by a Brambilla waveguide array

A computer code for calculating the predictions of the Brambilla theory of lower-hybrid wave launching is documented

Enhancement of the neutral-beam stopping cross section in fusion plasmas due to multistep collision processes

Multistep processes involving excited atomic states are found to produce a substantial increase in the stopping cross section for a neutral hydrogen beam injected into a plasma, and thus to reduce the beam penetration. For typical plasma and beam parameters of current large tokamak experiments, the stopping cross-sectional enhancement is found to vary from 25% to 50% depending on the beam energy, plasma density, and impurity level. For neutral hydrogen beams with energies greater than or equal to 500 keV, envisioned in tokamak amd mirror reactor designs, the enhancement can be as large as 80 to 90%

Model and simulations of hysteresis in magnetic cores

Using a theory of ferromagnetic hysteresis developed recently, we present simulations of the behavior of a ferrite core connected in series with an initially charged capacitor. Results are given for three materials and are shown to compare favorably with experiment. 5 refs., 10 figs., 3 tabs

EXPERIMENTAL SEARCH FOR A HEAVY ELECTRON.

A search for a heavy electron of the type considered by Low and Blackmon has been made by studying the inelastic scattering of 5 BeV electrons from hydrogen. The search was made over a range of values of the mass of the heavy electron from 100 to 1300 MeV. No evidence for such a particle was observed. Upper limits on the production cross sections were determined and employed to deduce limits on the values of the electron-photon-heavy electron coupling constant in Low and Blackmon's theory