Comparison of subjective and objective tools in transoral laser cordectomy for early glottic cancer: importance of voice handicap index.

Several studies in recent years have already reported good oncologic results with laser microsurgery in the treatment of early glottic carcinoma. We conducted a longitudinal voice evaluation, in patients with early glottic cancer who underwent transoral laser cordectomy, in order to assess the voice quality outcome and its relationship with objective and subjective (voice handicap index questionnaire and GIRBAS scale) means. Twenty-four previously untreated patients underwent transoral laser cordectomy for early glottic cancer. All patients underwent subjective and objective voice assessment according to the multidimensional voice protocol recommended by the European Laryngological Society including acoustic, perceptual and stroboscopic analysis combined to patient self assessment of voice (voice handicap index-VHI). These evaluations were performed before treatment and 6 months after the treatment. Vocal fold healing was complete in all cases by 6 months following surgery. Main voice parameters (subjective and objective) resulted improved at the 6-month control after surgery. In particular, voice handicap index (VHI) and GIRBAS scale resulted reliable for voice assessment and for the postoperative follow-up. In conclusion, VHI, GIRBAS, multidimensional voice program (MDVP) and spectroacoustic parameters showed a close trend in the present study, and this confirms the validity of the voice analysis performed by each tool

Homo- and Heterobimetallic Trihydride Complexes Stabilized by the Tripodal Phosphine Ligand MeC(CH2PPh2)3: Experimental and Theoretical Studies

The trihydride (triphos)RhH3 [triphos = MeC(CH2PPh2)3] reacts with coordinatively unsaturated metal fragments to form a family of bimetallic polyhydride complexes of general formula [(triphos)Rh(\u3bc-H)3M(L)]n+ [M = Rh, Co, L = triphos, n = 3, 2, 1; M = Ni, L = triphos, n = 2, 1; M = Fe, L = MeC(CH2PEt2)3, n = 2]. All of the compounds were isolated as BPh4-, ClO4-, or BF4- crystalline salts and their spectroscopic properties studied in detail by IR, NMR, and ESR techniques. The crystal structure of the paramagnetic homonuclear derivative [(triphos)Rh(\u3bc-H)3Rh(triphos)](BPh4) 2\ub7DMF was established by X-ray methods. Crystal data: triclinic, P1, a = 16.868 (4) \uc5, b = 15.863 (4) \uc5, c = 14.026 (3) \uc5, \u3b1 = 111.74 (2)\ub0, \u3b2 = 91.01 (2)\ub0, \u3b3 = 116.25(2)\ub0, Z = 1. The structure was refined to an R factor of 0.059 Rw = 0.064) by using 9149 unique reflections with I > 3\u3c3(I). The complex cation consists of two pyramidal L3Rh fragments (L = phosphine) held together by three bridging hydride ligands. The relative orientation of the L3Rh fragments is halfway between eclipsed and staggered, the overall symmetry of the molecule being approximately D3. The Rh-Rh separation measures 2.644 (1) \uc5. The electrochemical behavior in nonaqueous solvents shows that all of the compounds reversibly undergo multisequential one-electron-redox exchanges with no major variation of the primary geometry. NMR and ESR spectroscopies provide useful information concerning the geometric and electronic nature of diamagnetic and paramagnetic compounds, respectively. EHMO studies, not novel for this class of compounds, allow a new interpretation of the metal-metal bond in the dimers. In particular, the bond cannot be as strong as that predicted by simple electron-counting rules. Other comments are devoted to the potential existence of dimers with a bridging polyhydrogen unit [i.e. \u3bc-H3 vs (\u3bc-H)3]. Finally, the MO picture is used, on a very qualitative scale, to correlate structural, electrochemical, and spectroscopic parameters, in particular those derived from the ESR spectra

Documentation, Processing, and Representation of Architectural Heritage Through 3D Semantic Modelling

Documentation, data processing, and representation of Architectural Heritage through digital models are one of the main challenges in the field of conservation, preservation, management, and inclusive use and understanding of European heritage assets. In this framework, the impact of Industry 4.0 is more and more crucial, since new technologies, devices, and digital environment are strongly influencing the ways in which heritage contents are explored, used, managed, and shared, also in citizens’ everyday life. In this direction, the INCEPTION project – founded by the European Commission within the Horizon 2020 programme – develops key-targeted innovations in efficient 3D digitization methods, post-processing modelling tools, semantic web-based solutions, and applications to ensure a wide and aware access to digital Cultural Heritage. This chapter presents main actions achieved by INCEPTION