671 research outputs found
Substance P regulates puberty onset and fertility in the female mouse
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception, induces gonadotropin release in adult mice in a kisspeptin-dependent manner. Here, we assessed whether SP, through binding to its receptor NK1R (neurokinin 1 receptor), participates in the timing of puberty onset and fertility in the mouse. We observed that 1) selective NK1R agonists induce gonadotropin release in prepubertal females; 2) the expression of Tac1 (encoding SP) and Tacr1 (NK1R) in the arcuate nucleus is maximal before puberty, suggesting increased SP tone; 3) repeated exposure to NK1R agonists prepubertally advances puberty onset; and 4) female Tac1-/- mice display delayed puberty; moreover, 5) SP deficiency leads to subfertility in females, showing fewer corpora lutea and antral follicles and leading to decreased litter size. Thus, our findings support a role for SP in the stimulation of gonadotropins before puberty, acting via Kiss1 neurons to stimulate GnRH release, and its involvement in the attainment of full reproductive capabilities in female mice. Copyright © 2015 by the Endocrine Society
Production of Medical Radioisotopes with High Specific Activity in Photonuclear Reactions with Beams of High Intensity and Large Brilliance
We study the production of radioisotopes for nuclear medicine in
photonuclear reactions or ()
photoexcitation reactions with high flux [()/s], small
diameter m and small band width () beams produced by Compton back-scattering of laser
light from relativistic brilliant electron beams. We compare them to (ion,np) reactions with (ion=p,d,) from particle accelerators like
cyclotrons and (n,) or (n,f) reactions from nuclear reactors. For
photonuclear reactions with a narrow beam the energy deposition in the
target can be managed by using a stack of thin target foils or wires, hence
avoiding direct stopping of the Compton and pair electrons (positrons).
isomer production via specially selected cascades
allows to produce high specific activity in multiple excitations, where no
back-pumping of the isomer to the ground state occurs. We discuss in detail
many specific radioisotopes for diagnostics and therapy applications.
Photonuclear reactions with beams allow to produce certain
radioisotopes, e.g. Sc, Ti, Cu, Pd, Sn,
Er, Pt or Ac, with higher specific activity and/or
more economically than with classical methods. This will open the way for
completely new clinical applications of radioisotopes. For example Pt
could be used to verify the patient's response to chemotherapy with platinum
compounds before a complete treatment is performed. Also innovative isotopes
like Sc, Cu and Ac could be produced for the first time
in sufficient quantities for large-scale application in targeted radionuclide
therapy.Comment: submitted to Appl. Phys.
Supersymmetric codimension-two branes and U(1)_R mediation in 6D gauged supergravity
We construct a consistent supersymmetric action for brane chiral and vector
multiplets in a six-dimensional chiral gauged supergravity. A nonzero brane
tension can be accommodated by allowing for a brane-localized Fayet-Iliopoulos
term proportional to the brane tension. When the brane chiral multiplet is
charged under the bulk U(1)_R, we obtain a nontrivial coupling to the extra
component of the U(1)_R gauge field strength as well as a singular scalar
self-interaction term. Dimensionally reducing to 4D on a football
supersymmetric solution, we discuss the implication of such interactions for
obtaining the U(1)_R D-term in the 4D effective supergravity. By assuming the
bulk gaugino condensates and nonzero brane F- and/or D-term for the uplifting
potential, we have all the moduli stabilized with a vanishing cosmological
constant. The brane scalar with nonzero R charge then gets a soft mass of order
the gravitino mass. The overall sign of the soft mass squared depends on the
sign of the R charge as well as whether the brane F- or D-term dominates.Comment: 28 pages, no figures, version to appear in JHE
Discussing Quantum Aspects of Higher-Derivative 3D-Gravity in the First-Order Formalism
In this paper, we reassess the issue of deriving the propagators and
identifying the spectrum of excitations associated to the vielbein and spin
connection of (1+2)-D gravity in the presence of dynamical torsion, while
working in the first-order formulation. A number of peculiarities is pointed
out whenever the Chern-Simons term is taken into account along with a
combination of bilinear terms in the torsion tensor. We present a procedure to
derive the full set of propagators, based on an algebra of enlarged spin-type
operators, and we discuss under which conditions the poles of the tree-level
2-point functions correspond to physical excitations that do not conflict with
causality and unitarity
Casimir Energies for 6D Supergravities Compactified on T_2/Z_N with Wilson Lines
We compute (as functions of the shape and Wilson-line moduli) the one-loop
Casimir energy induced by higher-dimensional supergravities compactified from
6D to 4D on 2-tori, and on some of their Z_N orbifolds. Detailed calculations
are given for a 6D scalar field having an arbitrary 6D mass m, and we show how
to extend these results to higher-spin fields for supersymmetric 6D theories.
Particular attention is paid to regularization issues and to the identification
of the divergences of the potential, as well as the dependence of the result on
m, including limits for which m^2 A> 1 where A is the volume of
the internal 2 dimensions. Our calculation extends those in the literature to
very general boundary conditions for fields about the various cycles of these
geometries. The results have potential applications towards Supersymmetric
Large Extra Dimensions (SLED) as a theory of the Dark Energy. First, they
provide an explicit calculation within which to follow the dependence of the
result on the mass of the bulk states which travel within the loop, and for
heavy masses these results bear out the more general analysis of the
UV-sensitivity obtained using heat-kernel methods. Second, because the
potentials we find describe the dynamics of the classical flat directions of
these compactifications, within SLED they would describe the present-day
dynamics of the Dark Energy.Comment: 40 pages, 7 figure
Testing spatial noncommutativiy via the Aharonov-Bohm effect
The possibility of detecting noncommutative space relics is analyzed using
the Aharonov-Bohm effect. We show that, if space is noncommutative, the
holonomy receives non-trivial kinematical corrections that will produce a
diffraction pattern even when the magnetic flux is quantized. The scattering
problem is also formulated, and the differential cross section is calculated.
Our results can be extrapolated to high energy physics and the bound is found. If this bound holds, then noncommutative
effects could be explored in scattering experiments measuring differential
cross sections for small angles. The bound state Aharonov- Bohm effect is also
discussed.Comment: 16 pp, Revtex 4, 2 fig, new references added. To appear in PR
Precision Pion-Proton Elastic Differential Cross Sections at Energies Spanning the Delta Resonance
A precision measurement of absolute pi+p and pi-p elastic differential cross
sections at incident pion laboratory kinetic energies from T_pi= 141.15 to
267.3 MeV is described. Data were obtained detecting the scattered pion and
recoil proton in coincidence at 12 laboratory pion angles from 55 to 155
degrees for pi+p, and six angles from 60 to 155 degrees for pi-p. Single arm
measurements were also obtained for pi+p energies up to 218.1 MeV, with the
scattered pi+ detected at six angles from 20 to 70 degrees. A flat-walled,
super-cooled liquid hydrogen target as well as solid CH2 targets were used. The
data are characterized by small uncertainties, ~1-2% statistical and ~1-1.5%
normalization. The reliability of the cross section results was ensured by
carrying out the measurements under a variety of experimental conditions to
identify and quantify the sources of instrumental uncertainty. Our lowest and
highest energy data are consistent with overlapping results from TRIUMF and
LAMPF. In general, the Virginia Polytechnic Institute SM95 partial wave
analysis solution describes our data well, but the older Karlsruhe-Helsinki PWA
solution KH80 does not.Comment: 39 pages, 22 figures (some with quality reduced to satisfy ArXiv
requirements. Contact M.M. Pavan for originals). Submitted to Physical Review
Laser-Driven Ultrafast Field Propagation on Solid Surfaces
The interaction of a 3×1019  W/cm2 laser pulse with a metallic wire has been investigated using proton radiography. The pulse is observed to drive the propagation of a highly transient field along the wire at the speed of light. Within a temporal window of 20 ps, the current driven by this field rises to its peak magnitude ∼104  A before decaying to below measurable levels. Supported by particle-in-cell simulation results and simple theoretical reasoning, the transient field measured is interpreted as a charge-neutralizing disturbance propagated away from the interaction region as a result of the permanent loss of a small fraction of the laser-accelerated hot electron population to vacuum
Dust Devil Tracks
Dust devils that leave dark- or light-toned tracks are common on Mars and they can also be found on the Earth’s surface. Dust devil tracks (hereinafter DDTs) are ephemeral surface features with mostly sub-annual lifetimes. Regarding their size, DDT widths can range between ∼1 m and ∼1 km, depending on the diameter of dust devil that created the track, and DDT lengths range from a few tens of meters to several kilometers, limited by the duration and horizontal ground speed of dust devils. DDTs can be classified into three main types based on their morphology and albedo in contrast to their surroundings; all are found on both planets: (a) dark continuous DDTs, (b) dark cycloidal DDTs, and (c) bright DDTs. Dark continuous DDTs are the most common type on Mars. They are characterized by their relatively homogenous and continuous low albedo surface tracks. Based on terrestrial and martian in situ studies, these DDTs most likely form when surficial dust layers are removed to expose larger-grained substrate material (coarse sands of ≥500 μm in diameter). The exposure of larger-grained materials changes the photometric properties of the surface; hence leading to lower albedo tracks because grain size is photometrically inversely proportional to the surface reflectance. However, although not observed so far, compositional differences (i.e., color differences) might also lead to albedo contrasts when dust is removed to expose substrate materials with mineralogical differences. For dark continuous DDTs, albedo drop measurements are around 2.5 % in the wavelength range of 550–850 nm on Mars and around 0.5 % in the wavelength range from 300–1100 nm on Earth. The removal of an equivalent layer thickness around 1 μm is sufficient for the formation of visible dark continuous DDTs on Mars and Earth. The next type of DDTs, dark cycloidal DDTs, are characterized by their low albedo pattern of overlapping scallops. Terrestrial in situ studies imply that they are formed when sand-sized material that is eroded from the outer vortex area of a dust devil is redeposited in annular patterns in the central vortex region. This type of DDT can also be found in on Mars in orbital image data, and although in situ studies are lacking, terrestrial analog studies, laboratory work, and numerical modeling suggest they have the same formation mechanism as those on Earth. Finally, bright DDTs are characterized by their continuous track pattern and high albedo compared to their undisturbed surroundings. They are found on both planets, but to date they have only been analyzed in situ on Earth. Here, the destruction of aggregates of dust, silt and sand by dust devils leads to smooth surfaces in contrast to the undisturbed rough surfaces surrounding the track. The resulting change in photometric properties occurs because the smoother surfaces have a higher reflectance compared to the surrounding rough surface, leading to bright DDTs. On Mars, the destruction of surficial dust-aggregates may also lead to bright DDTs. However, higher reflective surfaces may be produced by other formation mechanisms, such as dust compaction by passing dust devils, as this may also cause changes in photometric properties. On Mars, DDTs in general are found at all elevations and on a global scale, except on the permanent polar caps. DDT maximum areal densities occur during spring and summer in both hemispheres produced by an increase in dust devil activity caused by maximum insolation. Regionally, dust devil densities vary spatially likely controlled by changes in dust cover thicknesses and substrate materials. This variability makes it difficult to infer dust devil activity from DDT frequencies. Furthermore, only a fraction of dust devils leave tracks. However, DDTs can be used as proxies for dust devil lifetimes and wind directions and speeds, and they can also be used to predict lander or rover solar panel clearing events. Overall, the high DDT frequency in many areas on Mars leads to drastic albedo changes that affect large-scale weather patterns
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