9 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Mineralização do carbono orgùnico em solos tratados com lodo de curtume Mineralization of the organic carbon in soils treated with tannery sludges
O objetivo deste trabalho foi avaliar a mineralização do carbono orgĂąnico do lodo de curtume, aplicado em solos com diferentes classes texturais, de modo a caracterizar a cinĂ©tica do processo de mineralização e auxiliar na elaboração de normas tĂ©cnicas sobre o uso agrĂcola desse material. Foram conduzidos experimentos de incubação por 105 dias, em laboratĂłrio, utilizando-se trĂȘs solos: Nitossolo Vermelho eutrofĂ©rrico tĂpico (NVef), Latossolo Vermelho-Amarelo distrĂłfico tĂpico (LVAd) e Neossolo QuartzarĂȘnico Ăłrtico tĂpico (RQo). O lodo de curtume utilizado nos experimentos foi composto de uma mistura, na proporção de 1:1, do lodo do caleiro e do lodo primĂĄrio da estação de tratamento de efluentes, resultante da precipitação dos efluentes gerados no processo, com exceção dos efluentes que contĂȘm cromo. As doses aplicadas (base seca) no NVef e LVAd foram equivalentes a 0, 6, 12, 24 e 36 Mg ha-1 e a 0, 3, 6, 12 e 24 Mg ha-1 no RQo. NĂŁo se observa prejuĂzo Ă atividade microbiana dos solos, avaliada por meio da respiração basal, e a mineralização do carbono adicionado por meio do lodo de curtume Ă© intensa nos primeiros 15 a 20 dias de incubação.<br>The objective of this work was to evaluate the mineralization of the organic carbon derived from the tannery sludge applied in increasing doses on soils with different textures, to evaluate the decomposition kinetics, as well as to learn about the impact of this residue on the soil microbial community. This knowledge will be helpful for the establishment of technical rules about the agricultural use of the tannery sludges. Incubation experiments were carried out in the laboratory for 105 days, using three soils: a Kandiudalfic Eutrudox (NVef), a Typic Hapludox (LVAd) and a Typic Quartzipsamment (RQo). Tannery sludge used in these experiments was composed of a mixture of liming sludge and the primary sludge from the wastewater treatment station, in the proportion 1:1, with the exception of the wastewater with chromium. The doses of sludge (dry basis) added to the NVef and the LVAd soils were equivalent to 0, 6, 12, 24 and 36 Mg ha-1, and 0, 3, 6, 12 and 24 Mg ha-1 were added to the RQo soil. Soil microbial activity was not inhibited, even by the highest doses, and the most intense carbon degradation occurred on the first 15 to 20 days of incubation
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022. The Author(s)
New insights into the genetic etiology of Alzheimerâs disease and related dementias
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)