13,190 research outputs found

    Calibration of a fission gas monitor

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    Calibration of argon gas neutron activation sampling devic

    Radioisotope thermal photovoltaic application of the GaSb solar cell

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    An examination of a RTVP (radioisotopic thermophotovoltaic) conceptual design has shown a high potential for power densities well above those achievable with radioisotopic thermoelectric generator (RTG) systems. An efficiency of 14.4 percent and system specific power of 9.25 watts/kg were predicted for a system with sixteen GPHS (general purpose heat source) sources operating at 1100 C. The models also showed a 500 watt system power by the strontium-90 isotope at 1200 C at an efficiency of 17.0 percent and a system specific power of 11.8 watts/kg. The key to this level of performance is a high-quality photovoltaic cell with narrow bandgap and a reflective rear contact. Recent work at Boeing on GaSb cells and transparent back GaAs cells indicate that such a cell is well within reach

    Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling

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    <p>Abstract</p> <p>Background</p> <p>Surgical removal of the lens from larval <it>Xenopus laevis </it>results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arising from the unprecedented exposure of the cornea to the vitreous humour that occurs following lens removal. The molecular identity of this trigger is unknown.</p> <p>Results</p> <p>Here, we have used a functional transgenic approach to show that BMP signalling is required for lens regeneration and a microarray approach to identify genes that are upregulated specifically during this process. Analysis of the array data strongly implicates Wnt signalling and the Pitx family of transcription factors in the process of cornea to lens transdifferentiation. Our analysis also captured several genes associated with congenital cataract in humans. Pluripotency genes, in contrast, were not upregulated, supporting the idea that corneal cells transdifferentiate without returning to a stem cell state. Several genes from the array were expressed in the forming lens during embryogenesis. One of these, <it>Nipsnap1</it>, is a known direct target of BMP signalling.</p> <p>Conclusions</p> <p>Our results strongly implicate the developmental Wnt and BMP signalling pathways in the process of cornea to lens transdifferentiation (CLT) in <it>Xenopus</it>, and suggest direct transdifferentiation between these two anterior eye tissues.</p

    The effect of site practices on the integrity of large diameter bored piles

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    In South Africa, concrete in large diameter bored piles is generally placed by discharging a high flow concrete mix directly from the truck mixer and allowing the concrete to fall freely to the base of the pile hole. While certain site practices have been used by piling contractors for years, many engineers are not convinced of their acceptability. This paper discusses the results of an investigation which assessed the effect of site practices on the integrity of cast in-situ bored piles. Such practices include the method of concrete placement and the amount of water and/or loose spoil in the pile hole at the time of casting. The results of this investigation dispel the myth that the free fall placement of concrete in clean, dry pile holes has a detrimental effect on the degree of compaction and compressive strength of the concrete
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