Income Security for Workers: A Stressed Support System in Need of Innovation

The current mix of public and private programs to support workers after they experience disability onset provides benefits to millions of workers and former workers. Yet, despite the large and growing costs of these programs, the inflation-adjusted household incomes of workers with disabilities have been falling for over two decades, both absolutely and, especially, relative to the incomes of those without disabilities. The aging of the baby boom generation is likely to make matters worse, and the government’s fiscal circumstance will make it increasingly difficult to sustain existing public programs. Current public policy initiatives might eventually improve the disability support system, but they are not likely to ward off the adverse consequences of the pending crisis. Policy changes that leverage existing private sector practices and capabilities might achieve greater success, but have received little attention and are far from proven

Definition, conservation and epigenetics of housekeeping and tissue-enriched genes

<p>Abstract</p> <p>Background</p> <p>Housekeeping genes (HKG) are constitutively expressed in all tissues while tissue-enriched genes (TEG) are expressed at a much higher level in a single tissue type than in others. HKGs serve as valuable experimental controls in gene and protein expression experiments, while TEGs tend to represent distinct physiological processes and are frequently candidates for biomarkers or drug targets. The genomic features of these two groups of genes expressed in opposing patterns may shed light on the mechanisms by which cells maintain basic and tissue-specific functions.</p> <p>Results</p> <p>Here, we generate gene expression profiles of 42 normal human tissues on custom high-density microarrays to systematically identify 1,522 HKGs and 975 TEGs and compile a small subset of 20 housekeeping genes which are highly expressed in all tissues with lower variance than many commonly used HKGs. Cross-species comparison shows that both the functions and expression patterns of HKGs are conserved. TEGs are enriched with respect to both segmental duplication and copy number variation, while no such enrichment is observed for HKGs, suggesting the high expression of HKGs are not due to high copy numbers. Analysis of genomic and epigenetic features of HKGs and TEGs reveals that the high expression of HKGs across different tissues is associated with decreased nucleosome occupancy at the transcription start site as indicated by enhanced DNase hypersensitivity. Additionally, we systematically and quantitatively demonstrated that the CpG islands' enrichment in HKGs transcription start sites (TSS) and their depletion in TEGs TSS. Histone methylation patterns differ significantly between HKGs and TEGs, suggesting that methylation contributes to the differential expression patterns as well.</p> <p>Conclusion</p> <p>We have compiled a set of high quality HKGs that should provide higher and more consistent expression when used as references in laboratory experiments than currently used HKGs. The comparison of genomic features between HKGs and TEGs shows that HKGs are more conserved than TEGs in terms of functions, expression pattern and polymorphisms. In addition, our results identify chromatin structure and epigenetic features of HKGs and TEGs that are likely to play an important role in regulating their strikingly different expression patterns.</p

Turbulence and Multiscaling in the Randomly Forced Navier Stokes Equation

We present an extensive pseudospectral study of the randomly forced Navier-Stokes equation (RFNSE) stirred by a stochastic force with zero mean and a variance $\sim k^{4-d-y}$, where $k$ is the wavevector and the dimension $d = 3$. We present the first evidence for multiscaling of velocity structure functions in this model for $y \geq 4$. We extract the multiscaling exponent ratios $\zeta_p/\zeta_2$ by using extended self similarity (ESS), examine their dependence on $y$, and show that, if $y = 4$, they are in agreement with those obtained for the deterministically forced Navier-Stokes equation ($3d$NSE). We also show that well-defined vortex filaments, which appear clearly in studies of the $3d$NSE, are absent in the RFNSE.Comment: 4 pages (revtex), 6 figures (postscript

Finite size corrections to scaling in high Reynolds number turbulence

We study analytically and numerically the corrections to scaling in turbulence which arise due to the finite ratio of the outer scale $L$ of turbulence to the viscous scale $\eta$, i.e., they are due to finite size effects as anisotropic forcing or boundary conditions at large scales. We find that the deviations \dzm from the classical Kolmogorov scaling $\zeta_m = m/3$ of the velocity moments \langle |\u(\k)|^m\rangle \propto k^{-\zeta_m} decrease like $\delta\zeta_m (Re) =c_m Re^{-3/10}$. Our numerics employ a reduced wave vector set approximation for which the small scale structures are not fully resolved. Within this approximation we do not find $Re$ independent anomalous scaling within the inertial subrange. If anomalous scaling in the inertial subrange can be verified in the large $Re$ limit, this supports the suggestion that small scale structures should be responsible, originating from viscosity either in the bulk (vortex tubes or sheets) or from the boundary layers (plumes or swirls)

Circulation Statistics in Three-Dimensional Turbulent Flows

We study the large $\lambda$ limit of the loop-dependent characteristic functional $Z(\lambda)=$, related to the probability density function (PDF) of the circulation around a closed contour $c$. The analysis is carried out in the framework of the Martin-Siggia-Rose field theory formulation of the turbulence problem, by means of the saddle-point technique. Axisymmetric instantons, labelled by the component $\sigma_{zz}$ of the strain field -- a partially annealed variable in our formalism -- are obtained for a circular loop in the $xy$ plane, with radius defined in the inertial range. Fluctuations of the velocity field around the saddle-point solutions are relevant, leading to the lorentzian asymptotic behavior $Z(\lambda) \sim 1/{\lambda^2}$. The ${\cal O}(1 / {\lambda^4})$ subleading correction and the asymmetry between right and left PDF tails due to parity breaking mechanisms are also investigated.Comment: Computations are discussed in a more detailed way; accepted for publication in Physical Review

Yakhot's model of strong turbulence: A generalization of scaling models of turbulence

We report on some implications of the theory of turbulence developed by V. Yakhot [V. Yakhot, Phys. Rev. E {\bf 57}(2) (1998)]. In particular we focus on the expression for the scaling exponents $\zeta_{n}$. We show that Yakhot's result contains three well known scaling models as special cases, namely K41, K62 and the theory by V. L'vov and I. Procaccia [V. L'vov & I. Procaccia, Phys. Rev. E {\bf 62}(6) (2000)]. The model furthermore yields a theoretical justification for the method of extended self--similarity (ESS).Comment: 8 page

Lymph node removal enhances corneal graft survival in mice at high risk of rejection

Peer reviewedPublisher PD

Precise Measurement of Gravity Variations During a Total Solar Eclipse

The variations of gravity were measured with a high precision LaCoste-Romberg D gravimeter during a total solar eclipse to investigate the effect of solar eclipse on the gravitational field. The observed anomaly $(7.0 \pm 2.7) \times 10^{-8}$ m/s$^2$ during the eclipse implies that there may be a shielding property of gravitation

Reversible viscosity and Navier--Stokes fluids

Exploring the possibility of describing a fluid flow via a time-reversible equation and its relevance for the fluctuations statistics in stationary turbulent (or laminar) incompressible Navier-Stokes flows.Comment: 7 pages 6 figures, v2: replaced Fig.6 and few changes. Last version: appendix cut shorter, because of a computational erro

Inertial- and Dissipation-Range Asymptotics in Fluid Turbulence

We propose and verify a wave-vector-space version of generalized extended self similarity and broaden its applicability to uncover intriguing, universal scaling in the far dissipation range by computing high-order (\leq 20\/) structure functions numerically for: (1) the three-dimensional, incompressible Navier Stokes equation (with and without hyperviscosity); and (2) the GOY shell model for turbulence. Also, in case (2), with Taylor-microscale Reynolds numbers 4 \times 10^{4} \leq Re_{\lambda} \leq 3 \times 10^{6}\/, we find that the inertial-range exponents (\zeta_{p}\/) of the order - p\/ structure functions do not approach their Kolmogorov value p/3\/ as Re_{\lambda}\/ increases.Comment: RevTeX file, with six postscript figures. epsf.tex macro is used for figure insertion. Packaged using the 'uufiles' utilit