62 research outputs found
HIPASS High-Velocity Clouds: Properties of the Compact and Extended Populations
A catalog of Southern anomalous-velocity HI clouds at Decl. < +2 deg is
presented, based on data from the HI Parkes All-Sky Survey (HIPASS). The
improved sensitivity (5sigma: T_B = 0.04 K) and resolution (15.5') of the
HIPASS data results in a substantial increase in the number of individual
clouds (1956, as well as 41 galaxies) compared to previous surveys. Most
high-velocity emission features, HVCs, have a filamentary morphology and are
loosely organized into large complexes extending over tens of degrees. In
addition, 179 compact and isolated anomalous-velocity objects, CHVCs, are
identified based on their size and degree of isolation. 25% of the CHVCs
originally classified by Braun & Burton (1999) are reclassified. Both the
entire population of high-velocity emission features and the CHVCs alone have
typical HI masses of ~ 4.5 D(kpc)^2 solar masses and have similar slopes for
their column density and flux distributions. On the other hand, the CHVCs
appear to be clustered and the population can be broken up into three spatially
distinct groups, while the entire population of clouds is more uniformly
distributed with a significant percentage aligned with the Magellanic Stream.
The median velocities are V_GSR = -38 km/s for the CHVCs and -30 km/s for all
of the anomalous-velocity clouds. Based on the catalog sizes, high-velocity
features cover 19% of the southern sky and CHVCs cover 1%. (abridged)Comment: 32 pages, 26 figures in gif format, 2 ascii tables, to appear in the
Jan 2002 issue of The Astronomical Journal, high resolution version available
at http://origins.Colorado.EDU/~mputman/pubs.htm
Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells
The deoxycytidine analogue 2′,2′-difluoro-2′-deoxycytidine (dFdC, gemcitabine) is a potent radiosensitiser, but has limited efficacy in combination with radiotherapy in patients with pancreatic cancer due to acute toxicity. We investigated whether cyclopentenyl cytosine (CPEC), targetting the ‘de novo' biosynthesis of cytidine triphosphate (CTP), could increase dFdC cytotoxicity alone or in combination with irradiation in a panel of human pancreatic cancer cells (Panc-1, Miapaca-2, BxPC-3). To investigate the role of deoxycytidine kinase (dCK), the rate-limiting enzyme in the activation of dFdC, human lung cancer cells without (dFdC-resistant SWg) and with an intact dCK gene (dFdC-sensitive SWp) were included. We found that CPEC (100–1000 nmol l−1) specifically reduced CTP levels in a dose-dependent manner that lasted up to 72 h in all cell lines. Preincubation with CPEC resulted in a dose-dependent increase in dFdC incorporated into the DNA only in dFdC-sensitive cells. Consequently, CPEC increased the effectiveness of dFdC (300 nmol l−1 for 4 h) only in dFdC-sensitive cells, which was accompanied by an increase in apoptosis. We also found that CPEC enhanced the radiosensitivity of cells treated with dFdC (30–300 nmol l−1 for 4 h). These results indicate that CPEC enhances the cytotoxicity of dFdC alone and in combination with irradiation in several human tumour cell lines with an intact dCK gene
Randomized Delayed-Start Trial of Levodopa in Parkinson's Disease
BACKGROUND Levodopa is the main treatment for symptoms of Parkinson's disease. Determining whether levodopa also has a disease-modifying effect could provide guidance as to when in the course of the disease the treatment with this drug should be initiated. METHODS In a multicenter, double-blind, placebo-controlled, delayed-start trial, we randomly assigned patients with early Parkinson's disease to receive levodopa (100 mg three times per day) in combination with carbidopa (25 mg three times per day) for 80 weeks (early-start group) or placebo for 40 weeks followed by levodopa in combination with carbidopa for 40 weeks (delayed-start group). The primary outcome was the between-group difference in the mean change from baseline to week 80 in the total score on the Unified Parkinson's Disease Rating Scale (UPDRS; scores range from 0 to 176, with higher scores signifying more severe disease). Secondary analyses included the progression of symptoms, as measured by the UPDRS score, between weeks 4 and 40 and the noninferiority of early initiation of treatment to delayed initiation between weeks 44 and 80, with a noninferiority margin of 0.055 points per week. RESULTS A total of 445 patients were randomly assigned: 222 to the early-start group and 223 to the delayed-start group. The mean (+/- SD) UPDRS score at baseline was 28.1 +/- 11.4 points in the early-start group and 29.3 +/- 12.1 points in the delayed-start group. The change in UPDRS score from baseline to week 80 was -1.0 +/- 13.1 points and -2.0 +/- 13.0 points, respectively (difference, 1.0 point; 95% confidence interval [CI], -1.5 to 3.5; P = 0.44); this finding of no significant between-group difference at week 80 implies that levodopa had no disease-modifying effect. Between weeks 4 and 40, the rate of progression of symptoms, as measured in UPDRS points per week, was 0.04 +/- 0.23 in the early-start group and 0.06 +/- 0.34 in the delayed-start group (difference, -0.02; 95% CI, -0.07 to 0.03). The corresponding rates between weeks 44 and 80 were 0.10 +/- 0.25 and 0.03 +/- 0.28 (difference, 0.07; two-sided 90% CI, 0.03 to 0.10); the difference in the rate of progression between weeks 44 and 80 did not meet the criterion for noninferiority of early receipt of levodopa to delayed receipt. The rates of dyskinesia and levodopa-related fluctuations in motor response did not differ significantly between the two groups. CONCLUSIONS Among patients with early Parkinson's disease who were evaluated over the course of 80 weeks, treatment with levodopa in combination with carbidopa had no disease-modifying effect
Improved segmentation of neonatal brain MRI scans by addressing motion artifacts with data interpolation
negatively affect segmentation. The purpose of this study was to investigate whether motion-affected slices can be replaced by interpolated slices to enhance segmentation of neonatal brain MRI scans.
METHODS: From August 2017 to November 2019, moderate-late preterm infants were enrolled in a prospective cohort study entitled Brain Imaging in Moderate-late Preterm infants (BIMP-study). Around term equivalent age, MRI of the brain was performed using a 3 Tesla MRI. T2-weighed (voxel size 0.35x0.35x2mm) transverse images were automatically segmented into eight brain structures with a neonatal segmentation toolbox [1]. Upon visual inspection, scans with motion artifacts that affected segmentation (25/112; motion group) and scans without motion artifacts (27/112; control group) were selected and used for analysis. Slices with motion artifacts were re-estimated using shape-preserving cubic spline interpolation [2, 3], followed by automatic segmentation of the interpolated scan. Analysis was performed in three stages. Firstly, scans from the control group were used to test interpolation reliability: 18/54 axial slices of these scans were interpolated. Segmentation results of uninterpolated and interpolated scans were compared using the Sørensen-Dice coefficient. Secondly, uninterpolated and interpolated volumes of the motion group were compared using the Wilcoxon Signed-Ranks test. Thirdly, interpolated volumes of the motion group were compared to uninterpolated volumes of the control group using the Mann-Whitney U test.
RESULTS: In the control group, Sørensen-Dice coefficients ranged between 0.87 and 0.97. In the motion group, interpolation resulted in a significant decrease of cortical (Z=-2.9, p=0.004) and deep gray matter (Z=-3.30, p<0.001), and a significant increase of white matter (Z=2.84, p=0.005) volumes. No significant differences were found between interpolated volumes of the motion group and uninterpolated volumes of the control group.
CONCLUSION: Shape preserving cubic spline interpolation enables reliable segmentation of motion-affected MRI scans in moderate-late preterm infants
The Interstellar Environment of our Galaxy
We review the current knowledge and understanding of the interstellar medium
of our galaxy. We first present each of the three basic constituents - ordinary
matter, cosmic rays, and magnetic fields - of the interstellar medium, laying
emphasis on their physical and chemical properties inferred from a broad range
of observations. We then position the different interstellar constituents, both
with respect to each other and with respect to stars, within the general
galactic ecosystem.Comment: 39 pages, 12 figures (including 3 figures in 2 parts
Control of star formation by supersonic turbulence
Understanding the formation of stars in galaxies is central to much of modern
astrophysics. For several decades it has been thought that stellar birth is
primarily controlled by the interplay between gravity and magnetostatic
support, modulated by ambipolar diffusion. Recently, however, both
observational and numerical work has begun to suggest that support by
supersonic turbulence rather than magnetic fields controls star formation. In
this review we outline a new theory of star formation relying on the control by
turbulence. We demonstrate that although supersonic turbulence can provide
global support, it nevertheless produces density enhancements that allow local
collapse. Inefficient, isolated star formation is a hallmark of turbulent
support, while efficient, clustered star formation occurs in its absence. The
consequences of this theory are then explored for both local star formation and
galactic scale star formation. (ABSTRACT ABBREVIATED)Comment: Invited review for "Reviews of Modern Physics", 87 pages including 28
figures, in pres
Radio emission from Supernova Remnants
The explosion of a supernova releases almost instantaneously about 10^51 ergs
of mechanic energy, changing irreversibly the physical and chemical properties
of large regions in the galaxies. The stellar ejecta, the nebula resulting from
the powerful shock waves, and sometimes a compact stellar remnant, constitute a
supernova remnant (SNR). They can radiate their energy across the whole
electromagnetic spectrum, but the great majority are radio sources. Almost 70
years after the first detection of radio emission coming from a SNR, great
progress has been achieved in the comprehension of their physical
characteristics and evolution. We review the present knowledge of different
aspects of radio remnants, focusing on sources of the Milky Way and the
Magellanic Clouds, where the SNRs can be spatially resolved. We present a brief
overview of theoretical background, analyze morphology and polarization
properties, and review and critical discuss different methods applied to
determine the radio spectrum and distances. The consequences of the interaction
between the SNR shocks and the surrounding medium are examined, including the
question of whether SNRs can trigger the formation of new stars. Cases of
multispectral comparison are presented. A section is devoted to reviewing
recent results of radio SNRs in the Magellanic Clouds, with particular emphasis
on the radio properties of SN 1987A, an ideal laboratory to investigate
dynamical evolution of an SNR in near real time. The review concludes with a
summary of issues on radio SNRs that deserve further study, and analyzing the
prospects for future research with the latest generation radio telescopes.Comment: Revised version. 48 pages, 15 figure
Interstellar Grains -- The 75th Anniversary
The year of 2005 marks the 75th anniversary since Trumpler (1930) provided
the first definitive proof of interstellar grains by demonstrating the
existence of general absorption and reddening of starlight in the galactic
plane. This article reviews our progressive understanding of the nature of
interstellar dust.Comment: invited review article for the "Light, Dust and Chemical Evolution"
conference (Gerace, Italy, 26--30 September 2004), edited by F. Borghese and
R. Saija, 2005, in pres
Origin of Galactic and Extragalactic Magnetic Fields
A variety of observations suggest that magnetic fields are present in all
galaxies and galaxy clusters. These fields are characterized by a modest
strength (10^{-7}-10^{-5} G) and huge spatial scale (~Mpc). It is generally
assumed that magnetic fields in spiral galaxies arise from the combined action
of differential rotation and helical turbulence, a process known as the
alpha-omega dynamo. However fundamental questions concerning the nature of the
dynamo as well as the origin of the seed fields necessary to prime it remain
unclear. Moreover, the standard alpha-omega dynamo does not explain the
existence of magnetic fields in elliptical galaxies and clusters. The author
summarizes what is known observationally about magnetic fields in galaxies,
clusters, superclusters, and beyond. He then reviews the standard dynamo
paradigm, the challenges that have been leveled against it, and several
alternative scenarios. He concludes with a discussion of astrophysical and
early Universe candidates for seed fields.Comment: 67 pages, 17 figures, accepted for publication in Reviews of Modern
Physic
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